Search in:

ImmunoTargets and Therapy Volume 10, 2021 - Issue

Submit an article Journal homepage

Open access

879

Views

CrossRef citations to date

Altmetric

Review

Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma

Reyisa BughdaDivision of Cancer Therapeutics, The Institute of Cancer Research, London, UKView further author information

Paraskevi DimouDivision of Cancer Therapeutics, The Institute of Cancer Research, London, UKView further author information

Reena R D’SouzaDivision of Cancer Therapeutics, The Institute of Cancer Research, London, UKView further author information

Astero KlampatsaDivision of Cancer Therapeutics, The Institute of Cancer Research, London, UKCorrespondence[email protected]

https://orcid.org/0000-0003-0572-502X View further author information

Pages 313-323 | Published online: 05 Aug 2021

Cite this article
CrossMark

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF View EPUB EPUB

Citations (25)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Articles from other publishers (25)

Sedigheh Shahvali, Niloufar Rahiman, Mahmoud Reza Jaafari & Leila Arabi. (2023) Targeting fibroblast activation protein (FAP): advances in CAR-T cell, antibody, and vaccine in cancer immunotherapy. Drug Delivery and Translational Research 13:7, pages 2041-2056.
Crossref

Shipra Das, Julien Valton, Philippe Duchateau & Laurent Poirot. (2023) Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy. Frontiers in Immunology 14.
Crossref

Grace Guzman, Megan R. Reed, Kevin Bielamowicz, Brian Koss & Analiz Rodriguez. (2023) CAR-T Therapies in Solid Tumors: Opportunities and Challenges. Current Oncology Reports 25:5, pages 479-489.
Crossref

Lukas Kessler. (2023) Fibroblast Activation Protein Inhibitor (FAPI)-PET Imaging in Sarcoma. PET Clinics.
Crossref

Ying Li, Shuai Xiang, Wenjun Pan, Jing Wang, Hanxiang Zhan & Shanglong Liu. (2023) Targeting tumor immunosuppressive microenvironment for pancreatic cancer immunotherapy: Current research and future perspective. Frontiers in Oncology 13.
Crossref

Dina V. Antonova, Dmitry A. Gnatenko, Elena S. Kotova, Victor V. Pleshkan, Alexey I. Kuzmich, Dmitry A. Didych, Eugene D. Sverdlov & Irina V. Alekseenko. (2023) Cell-specific expression of the FAP gene is regulated by enhancer elements. Frontiers in Molecular Biosciences 10.
Crossref

Yasushi Shintani, Toru Kimura, Soichiro Funaki, Naoko Ose, Takashi Kanou & Eriko Fukui. (2023) Therapeutic Targeting of Cancer-Associated Fibroblasts in the Non-Small Cell Lung Cancer Tumor Microenvironment. Cancers 15:2, pages 335.
Crossref

Abdolreza Esmaeilzadeh, Davood Jafari, Reza Elahi, Mahsa Bazargan, Maryam Zare Rafie & Amir Hossein Mansourabadi. 2023.

Farbod Ghobadinezhad, Zhila Izadi, Marzieh Ebrahimi & Nima Rezaei. 2023.

Ling Gu, Ping Liao & Hanmin Liu. (2022) Cancer-associated fibroblasts in acute leukemia. Frontiers in Oncology 12.
Crossref

Iris K. Lee, Estela Noguera-Ortega, Zebin Xiao, Leslie Todd, John Scholler, Decheng Song, Maria Liousia, Katheryn Lohith, Kexiang Xu, Kimberly J. Edwards, Michael D. Farwell, Carl H. June, Steven M. Albelda, Ellen Puré & Mark A. Sellmyer. (2022) Monitoring Therapeutic Response to Anti-FAP CAR T Cells Using [18F]AlF-FAPI-74. Clinical Cancer Research 28:24, pages 5330-5342.
Crossref

Benjamin H. Jenkins, Josephine F. Buckingham, Christopher J. Hanley & Gareth J. Thomas. (2022) Targeting cancer-associated fibroblasts: Challenges, opportunities and future directions. Pharmacology & Therapeutics 240, pages 108231.
Crossref

Fanfan Li, Shuping Zhao, Cheng Wei, Yaodi Hu, Tianlong Xu, Xueyi Xin, Tingwei Zhu, Liting Shang, Shanwen Ke, Jiang Zhou, Xiaojun Xu, Yue Gao, Ai Zhao & Jimin Gao. (2022) Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors. Frontiers in Immunology 13.
Crossref

Maosen Xu, Tao Zhang, Ruolan Xia, Yuquan Wei & Xiawei Wei. (2022) Targeting the tumor stroma for cancer therapy. Molecular Cancer 21:1.
Crossref

Jerome Thiery. (2022) Modulation of the antitumor immune response by cancer-associated fibroblasts: mechanisms and targeting strategies to hamper their immunosuppressive functions. Exploration of Targeted Anti-tumor Therapy, pages 598-629.
Crossref

Jie Shen, Dashuai Yang & Youming Ding. (2022) Advances in Promoting the Efficacy of Chimeric Antigen Receptor T Cells in the Treatment of Hepatocellular Carcinoma. Cancers 14:20, pages 5018.
Crossref

Yan-Ruide Li, Matthew Wilson & Lili Yang. (2022) Target tumor microenvironment by innate T cells. Frontiers in Immunology 13.
Crossref

Silvia Baldari, Francesca Di Modugno, Paola Nisticò & Gabriele Toietta. (2022) Strategies for Efficient Targeting of Tumor Collagen for Cancer Therapy. Cancers 14:19, pages 4706.
Crossref

Andreas Ritter, Nina-Naomi Kreis, Samira Catharina Hoock, Christine Solbach, Frank Louwen & Juping Yuan. (2022) Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells, Obesity and the Tumor Microenvironment of Breast Cancer. Cancers 14:16, pages 3908.
Crossref

Jiangang Sun, Xiaojing Li, Peng Chen & Yongshun Gao. (2022) From Anti-HER-2 to Anti-HER-2-CAR-T Cells: An Evolutionary Immunotherapy Approach for Gastric Cancer. Journal of Inflammation Research Volume 15, pages 4061-4085.
Crossref

Dengdi Hu, Zhaoqing Li, Bin Zheng, Xixi Lin, Yuehong Pan, Peirong Gong, Wenying Zhuo, Yujie Hu, Cong Chen, Lini Chen, Jichun Zhou & Linbo Wang. (2022) Cancer‐associated fibroblasts in breast cancer: Challenges and opportunities. Cancer Communications 42:5, pages 401-434.
Crossref

Siddharth Menon, Sagun Parakh, Andrew M. Scott & Hui K. Gan. (2022) Antibody-drug conjugates: beyond current approvals and potential future strategies. Exploration of Targeted Anti-tumor Therapy, pages 252-277.
Crossref

Alain E. Andrea, Andrada Chiron, Sarah Mallah, Stéphanie Bessoles, Guillaume Sarrabayrouse & Salima Hacein-Bey-Abina. (2022) Advances in CAR-T Cell Genetic Engineering Strategies to Overcome Hurdles in Solid Tumors Treatment. Frontiers in Immunology 13.
Crossref

Karla Paterson, Sarah Paterson, Theresa Mulholland, Seth B. Coffelt & Michele Zagnoni. (2022) Assessment of CAR-T Cell-Mediated Cytotoxicity in 3D Microfluidic Cancer Co-Culture Models for Combination Therapy. IEEE Open Journal of Engineering in Medicine and Biology 3, pages 86-95.
Crossref

Asier Antoñana-Vildosola, Samanta Romina Zanetti & Asis Palazon. 2022. Adoptive Cell Transfer. Adoptive Cell Transfer 123 147 .

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma

Articles from other publishers (25)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma

Citations (25)

Articles from other publishers (25)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date