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Journal of Asthma and Allergy Volume 11, 2018 - Issue
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Original Research

A purinergic P2Y6 receptor agonist prodrug modulates airway inflammation, remodeling, and hyperreactivity in a mouse model of asthma

Anne Chetty1 Department of Pediatrics, Tufts Medical Center, Boston, MA, USA, [email protected]
,
Azeem Sharda1 Department of Pediatrics, Tufts Medical Center, Boston, MA, USA, [email protected]
,
Rod Warburton2 Department of Medicine, Tufts Medical Center, Boston, MA, USA
,
Ellen O Weinberg3 Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA
,
Jinghui Dong4 Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA
,
Min Fang5 Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA
,
G Gary Sahagian5 Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA
,
Tiangmeng Chen3 Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA
,
Chang Xue3 Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA
,
John J Castellot3 Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA;6 Graduate Program in Cell, Molecular and Developmental Biology, Tufts University School of Medicine, Boston, MA, USA, [email protected]
,
Philip G Haydon4 Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA
&
Heber C Nielsen1 Department of Pediatrics, Tufts Medical Center, Boston, MA, USA, [email protected];6 Graduate Program in Cell, Molecular and Developmental Biology, Tufts University School of Medicine, Boston, MA, USA, [email protected]Correspondence[email protected]
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Pages 159-171 | Published online: 01 Aug 2018

Citations (14)

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Read on this site (4)

Anne Chetty & Heber C Nielsen. (2021) Targeting Airway Smooth Muscle Hypertrophy in Asthma: An Approach Whose Time Has Come. Journal of Asthma and Allergy 14, pages 539-556.
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Bruno Pietro Imbimbo, Stefania Ippati & Mark Watling. (2020) Should drug discovery scientists still embrace the amyloid hypothesis for Alzheimer’s disease or should they be looking elsewhere?. Expert Opinion on Drug Discovery 15:11, pages 1241-1251.
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Bruno P. Imbimbo, Madia Lozupone, Mark Watling & Francesco Panza. (2020) Discontinued disease-modifying therapies for Alzheimer’s disease: status and future perspectives. Expert Opinion on Investigational Drugs 29:9, pages 919-933.
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Marharyta Zyma & Rafał Pawliczak. (2020) Characteristics and the role of purinergic receptors in pathophysiology with focus on immune response. International Reviews of Immunology 39:3, pages 97-117.
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Articles from other publishers (10)

Kenneth A. Jacobson, Balaram Pradhan, Zhiwei Wen & Asmita Pramanik. (2023) New paradigms in purinergic receptor ligand discovery. Neuropharmacology 230, pages 109503.
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Jun Nagai, Junrui Lin & Joshua A. Boyce. (2022) Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation. The Journal of Immunology 209:12, pages 2293-2303.
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Young-Hwan Jung, Qasim Shah, Sarah A. Lewicki, Asmita Pramanik, Varun Gopinatth, Julie Pelletier, Jean Sévigny, Jamshed Iqbal & Kenneth A. Jacobson. (2022) Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 75, pages 128981.
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Paola Oliva, Mirko Scortichini, Clemens Dobelmann, Shanu Jain, Varun Gopinatth, Kiran S. Toti, Ngan B. Phung, Anna Junker & Kenneth A. Jacobson. (2021) Structure-activity relationships of pyrimidine nucleotides containing a 5′-α,β-methylene diphosphonate at the P2Y6 receptor. Bioorganic & Medicinal Chemistry Letters 45, pages 128137.
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Young-Hwan Jung, Shanu Jain, Varun Gopinatth, Ngan B. Phung, Zhan-Guo Gao & Kenneth A. Jacobson. (2021) Structure activity relationship of 3-nitro-2-(trifluoromethyl)-2H-chromene derivatives as P2Y6 receptor antagonists. Bioorganic & Medicinal Chemistry Letters 41, pages 128008.
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Rebecca J. Thompson, Ian Sayers, Katja Kuokkanen & Ian P. Hall. (2021) Purinergic Receptors in the Airways: Potential Therapeutic Targets for Asthma?. Frontiers in Allergy 2.
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Mélissa Girard, Steve Dagenais Bellefeuille, Émilie Eiselt, Rebecca Brouillette, Morgane Placet, Guillaume Arguin, Jean‐Michel Longpré, Philippe Sarret & Fernand‐Pierre Gendron. (2020) The P2Y 6 receptor signals through Gα q /Ca 2+ /PKCα and Gα 13 /ROCK pathways to drive the formation of membrane protrusions and dictate cell migration . Journal of Cellular Physiology 235:12, pages 9676-9690.
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Paulo Anastácio Furtado Pacheco, Roberta Tosta Diogo, Betina Quintanilha Magalhães & Robson Xavier Faria. (2020) Plant natural products as source of new P2 receptors ligands. Fitoterapia 146, pages 104709.
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Caroline M. Molle, Guillaume Arguin, Charlotte Jemfer, Morgane Placet, Steve Dagenais Bellefeuille & Fernand-Pierre Gendron. (2020) The expression of the P2Y6 receptor is regulated at the transcriptional level by p53. Biochemical and Biophysical Research Communications 524:4, pages 798-802.
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Jun Nagai, Barbara Balestrieri, Laura B. Fanning, Timothy Kyin, Haley Cirka, Junrui Lin, Marco Idzko, Andreas Zech, Edy Y. Kim, Patrick J. Brennan & Joshua A. Boyce. (2019) P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation. Journal of Clinical Investigation 129:12, pages 5169-5186.
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