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Journal of Asthma and Allergy Volume 12, 2019 - Issue
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Original Research

Two-Year Integrated Efficacy And Safety Analysis Of Benralizumab In Severe Asthma

J Mark FitzGerald1 Centre for Heart and Lung Health, The Lung Centre Vancouver General Hospital, UBC Institute for Heart and Lung Health, Vancouver, BC, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-8753-6056View further author information
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Eugene R Bleecker2 Divisions of Pharmacogenomics and Genetics, Genomics and Precision Medicine, University of Arizona College of Medicine, Tucson, AZ, United StatesORCID Iconhttps://orcid.org/0000-0002-4767-3494View further author information
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Arnaud Bourdin3 Department of Respiratory Diseases, Hôpital Arnaud De Villeneuve, Montpellier, FranceORCID Iconhttps://orcid.org/0000-0002-4645-5209View further author information
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William W Busse4 Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, United StatesORCID Iconhttps://orcid.org/0000-0003-2591-4696View further author information
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Gary T Ferguson5 Pulmonary Research Institute of Southeast Michigan, Farmington Hills, MI, United StatesView further author information
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Laura Brooks6 AstraZeneca, Gaithersburg, MD, United StatesView further author information
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Peter Barker6 AstraZeneca, Gaithersburg, MD, United StatesView further author information
&
Ubaldo J Martin6 AstraZeneca, Gaithersburg, MD, United StatesORCID Iconhttps://orcid.org/0000-0002-0089-7677View further author information
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Pages 401-413 | Published online: 09 Dec 2019

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Takanori Numata, Jun Araya, Keitaro Okuda, Hanae Miyagawa, Shunsuke Minagawa, Takeo Ishikawa, Hiromichi Hara & Kazuyoshi Kuwano. (2022) Long-Term Efficacy and Clinical Remission After Benralizumab Treatment in Patients with Severe Eosinophilic Asthma: A Retrospective Study. Journal of Asthma and Allergy 15, pages 1731-1741.
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Konstantinos Katsoulis, Maria Kipourou & Stelios Loukides. (2022) Reduction/elimination of blood eosinophils in severe asthma: should there be a safety consideration?. Expert Opinion on Biological Therapy 22:3, pages 377-384.
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Francesco Menzella, Marco Bonavia, Matteo Bonini, Maria D’Amato, Salvatore Lombardo, Nicola Murgia, Vincenzo Patella, Massimo Triggiani & Girolamo Pelaia. (2021) Real-World Experience with Benralizumab in Patients with Severe Eosinophilic Asthma: A Case Series. Journal of Asthma and Allergy 14, pages 149-161.
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Breda Cushen & Andrew Menzies-Gow. (2020) Benralizumab: an updated treatment of eosinophilic asthma. Expert Review of Respiratory Medicine 14:5, pages 435-444.
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Articles from other publishers (19)

Alessandra Vultaggio, Maria Aliani, Elena Altieri, Pietro Bracciale, Luisa Brussino, Maria Filomena Caiaffa, Paolo Cameli, Giorgio Walter Canonica, Cristiano Caruso, Stefano Centanni, Maria D’Amato, Fausto De Michele, Stefano Del Giacco, Fabiano Di Marco, Francesco Menzella, Girolamo Pelaia, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Gianenrico Senna, Marco Benci, Silvia Boarino & Jan Walter Schroeder. (2023) Long-term effectiveness of benralizumab in severe eosinophilic asthma patients treated for 96-weeks: data from the ANANKE study. Respiratory Research 24:1.
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Eugenio De Corso, Maria D’Amato, Giovanna Elisiana Carpagnano, Girolamo Pelaia & Matteo Bonini. (2023) The Comorbid Patient in the Spotlight: Efficacy of Benralizumab on Chronic Rhinosinusitis with Nasal Polyp Outcomes in Presence of Severe Asthma. Current Allergy and Asthma Reports.
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Marrissa J. McIntosh, Harkiran K. Kooner, Rachel L. Eddy, Angela Wilson, Hana Serajeddini, Anurag Bhalla, Christopher Licskai, Constance A. Mackenzie, Cory Yamashita & Grace Parraga. (2023) CT Mucus Score and 129Xe MRI Ventilation Defects After 2.5 Years’ Anti-IL-5Rα in Eosinophilic Asthma. Chest.
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David J. Jackson & Ian D. Pavord. (2023) Living without eosinophils: evidence from mouse and man. European Respiratory Journal 61:1, pages 2201217.
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Konstantinos Kostikas, Petros Bakakos, Petros Galanakis, Georgios Hillas, George Konstantinou, Michael Makris, Nikolas Mathioudakis, Konstantinos Porpodis, Nikoletta Rovina, Eleftherios Zervas & Stelios Loukides. (2022) Capturing patient-centered outcomes using innovative technologies in adults with severe eosinophilic asthma on benralizumab: Τhe EMPOWAIR real-world study design. Pneumon 35:4, pages 1-12.
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Mitchell M. Pitlick, James T. Li & Thanai Pongdee. (2022) Current and emerging biologic therapies targeting eosinophilic disorders. World Allergy Organization Journal 15:8, pages 100676.
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Takamasa Kitajima, Hirotaka Tamesada, Satoshi Marumo & Motonari Fukui. (2022) A case of organizing pneumonia in an asthmatic patient treated with benralizumab. Allergology International 71:3, pages 417-419.
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Sandra Rutting, Cindy Thamrin, Troy J. Cross, Gregory G. King & Katrina O. Tonga. (2022) Fixed Airflow Obstruction in Asthma: A Problem of the Whole Lung Not of Just the Airways. Frontiers in Physiology 13.
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Francesco Menzella, Elena Bargagli, Maria Aliani, Pietro Bracciale, Luisa Brussino, Maria Filomena Caiaffa, Cristiano Caruso, Stefano Centanni, Maria D’Amato, Stefano Del Giacco, Fausto De Michele, Fabiano Di Marco, Elide Anna Pastorello, Girolamo Pelaia, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Gianenrico Senna, Alessandra Vultaggio, Lucia Simoni, Alessandra Ori, Silvia Boarino, Gianfranco Vitiello, Elena Altieri & Giorgio Walter Canonica. (2022) ChAracterization of ItaliaN severe uncontrolled Asthmatic patieNts Key features when receiving Benralizumab in a real-life setting: the observational rEtrospective ANANKE study. Respiratory Research 23:1.
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Andy Bush, Anne M. Fitzpatrick, Sejal Saglani, William C. AndersonIIIIII & Stanley J. Szefler. (2022) Difficult-to-Treat Asthma Management in School-Age Children. The Journal of Allergy and Clinical Immunology: In Practice 10:2, pages 359-375.
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Stephanie Korn, Arnaud Bourdin, Geoffrey Chupp, Borja G. Cosio, Doug Arbetter, Mihir Shah & Esther Garcia Gil. (2021) Integrated Safety and Efficacy Among Patients Receiving Benralizumab for Up to 5 Years. The Journal of Allergy and Clinical Immunology: In Practice 9:12, pages 4381-4392.e4.
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Arabelle Abellard & Andrea A Pappalardo. (2023) Overview of Severe Asthma, with Emphasis on Pediatric Patients: A Review for Practitioners. Journal of Investigative Medicine 69:7, pages 1297-1309.
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Gilles Devouassoux. (2021) Biothérapie dans l’asthme sévère : ce qu’il faut savoir. La Presse Médicale Formation 2:2, pages 181-185.
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Misa Kusumoto & Bryan J. Mathis. (2021) Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder. Allergies 1:2, pages 92-107.
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Lynda Jarrell. (2021) Eosinophilic asthma and the role of monoclonal antibodies. The Nurse Practitioner 46:4, pages 21-27.
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Alojzija Hočevar, Peter Kopač, Žiga Rotar, Martina Plešivčnik Novljan & Sabina Škrgat. (2020) Eosinophilic granulomatosis with polyangiitis evolution during severe eosinophilic asthma treatment with benralizumab. The Journal of Allergy and Clinical Immunology: In Practice 8:7, pages 2448-2449.
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David J. Jackson, Stephanie Korn, Sameer K. Mathur, Peter Barker, Venkata G. Meka, Ubaldo J. Martin & James G. Zangrilli. (2020) Safety of Eosinophil-Depleting Therapy for Severe, Eosinophilic Asthma: Focus on Benralizumab. Drug Safety 43:5, pages 409-425.
Crossref
Hiroyuki Nagase, Shigeharu Ueki & Shigeharu Fujieda. (2020) The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: Asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis. Allergology International 69:2, pages 178-186.
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Marek Lommatzsch. (2020) Immune Modulation in Asthma: Current Concepts and Future Strategies. Respiration 99:7, pages 566-576.
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