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Review

Para-phenylenediamine allergy: current perspectives on diagnosis and management

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Pages 9-15 | Published online: 18 Jan 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Ali Aboalela. (2023) A Rare Case of Hair Dye Induced Oral Lichenoid Reaction. International Medical Case Reports Journal 16, pages 345-350.
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Nazeer Hussain Khan, Faiz Ullah, Taskin Aman Khan, Ujala Zafar, Muhammad Farhan Ali Khan, Muhammad Mustaqeem, Syed Sakhawat Shah, Dong-Dong Wu & Xin-Ying Ji. (2021) Personal-Care Cosmetic Practices in Pakistan: Current Perspectives and Management. Clinical, Cosmetic and Investigational Dermatology 14, pages 9-21.
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Kevin M. Towle, Ruth Y. Hwang, Ernest S. Fung, Dana M. Hollins & Andrew D. Monnot. (2020) Hair dye and risk of skin sensitization induction: a product survey and quantitative risk assessment for para-phenylenediamine (PPD). Cutaneous and Ocular Toxicology 39:4, pages 311-316.
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Roya S. Nazarian, Bijal Amin, Katia Papalezova, Nitin Ohri & Beth N. McLellan. (2019) Radiation tattoos mimicking melanoma: a clinical observation. Acta Oncologica 58:9, pages 1283-1285.
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Articles from other publishers (43)

Yongyu He, Yu Cao, Binji Nie & Junpu Wang. (2023) Mechanisms of impairment in hair and scalp induced by hair dyeing and perming and potential interventions. Frontiers in Medicine 10.
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Sander Vandeweege, Britt Debaene, Hilde Lapeere & Hans Verstraelen. (2022) A systematic review of allergic and irritant contact dermatitis of the vulva: The most important allergens/irritants and the role of patch testing. Contact Dermatitis 88:4, pages 249-262.
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Atie Saghi, Jian-Li Gao, Letizia Giampietro, Sarvananda letchuman & Ehsan Amiri-Ardekani. (2023) A mechanistic analysis of henna in G6PD deficiency patients. Toxicologie Analytique et Clinique 35:1, pages 23-32.
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Yanhong Niu, Yangguang Li, Fanpeng Ma, Manman Zhang, Xuan Chen & Bang-Ce Ye. (2022) Ratiometric electrochemical sensing platform based on N-doped MOF-derived CoNi/C for the determination of p-phenylenediamine in hair dyes. Microchimica Acta 190:1.
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Klimentina D. Gospodinova & Adriana D. Angelova. (2022) A Survey of Allergic Contact Dermatitis Among Hairdressers. Journal of Biomedical and Clinical Research 15:2, pages 171-177.
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Phoebe Star, Elizabeth Teng Yoke Chow, Jing Jing Li, Victoria J. Bray & Monisha Gupta. (2022) A case of hair dye‐induced allergic contact dermatitis in the context of nivolumab. Contact Dermatitis 87:4, pages 377-379.
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Geoffrey S. Kelly & Jasmine Gentry. (2022) Woman with rash. Journal of the American College of Emergency Physicians Open 3:5.
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Ivan Guryanov, Ekaterina Naumenko & Rawil Fakhrullin. (2022) Hair surface engineering: Combining nanoarchitectonics with hair topical and beauty formulations. Applied Surface Science Advances 7, pages 100188.
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Gopalakrishnan Venkatesan, Yuri Dancik, Yub Raj Neupane, Aneesh V. Karkhanis, Paul Bigliardi & Giorgia Pastorin. (2022) Synthesis and Assessment of Non-allergenic Aromatic Amine Hair Dyes as Efficient Alternatives to Paraphenylenediamine. ACS Sustainable Chemistry & Engineering 10:2, pages 838-849.
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Suryanarayana Polaka, Bhakti Pawar, Muktika Tekade, Rutuja Satvase, Aparna Lakshmi Manchikalapudi, Mukesh Chandra Sharma, Vikas Pandey, Aditya Narayan Jhariya & Rakesh Kumar Tekade. 2022. Pharmacokinetics and Toxicokinetic Considerations. Pharmacokinetics and Toxicokinetic Considerations 543 567 .
Gopalakrishnan Venkatesan, Zhi Chiaw Lim, Aneesh V. Karkhanis, Yub Raj Neupane, Yuri Dancik, Chenyuan Huang, Paul Bigliardi & Giorgia Pastorin. (2021) Investigations on detoxification mechanisms of novel para-phenylenediamine analogues through N-acetyltransferase 1 (NAT-1). Archives of Toxicology 96:1, pages 153-165.
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Zita‐Rose Manjaly Thomas, Dagmar Jamiolkowski, Sibylla Chantraine, Esther Steveling‐Klein, Kathrin Scherer Hofmeier & Karin Hartmann. (2021) Kontaktekzem auf Haarkosmetikprodukte: Aktuelle Empfehlungen zur Diagnostik. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 19:12, pages 1729-1735.
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Zita‐Rose Manjaly Thomas, Dagmar Jamiolkowski, Sibylla Chantraine, Esther Steveling‐Klein, Kathrin Scherer Hofmeier & Karin Hartmann. (2021) Contact dermatitis to hair cosmetics: Current diagnostic recommendations. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 19:12, pages 1729-1734.
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Abhimanew Dhir, Madhu Rajkumar & Gautam R. Desiraju. (2021) Cocrystal hydrate of Bandrowski's base and clotrimazole: a prospective ingredient for hair dye formulations. CrystEngComm 23:32, pages 5421-5424.
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Andrew Towns. (2021) A review of developments in industrial hair colorant actives for oxidative dyes. Coloration Technology 137:4, pages 301-335.
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Herbert Fink, Nuno M. de Barros Fernandes, Jörg Weissmann & Manfred Frey. (2020) Extraction With Sweat-Sebum Emulsion as a New Test Method for Leachables in Patch-Based Medical Devices, Illustrated by Assessment of Isobornylacrylate (IBOA) in Diabetes Products. Journal of Diabetes Science and Technology 15:4, pages 792-800.
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Niraj R Gowda, Joseph Delio, Amira Elshikh & Rahul Khosla. (2021) Hair-Dye-Related Accidental Poisoning and Death. Cureus.
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E. Pelechas, P. V. Voulgari & A. A. Drosos. (2020) Occupational mimics of rheumatoid arthritis: hair dye-induced arthritis. Rheumatology International 41:4, pages 795-797.
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Eric Omar Then, Tyler Grantham, Michell Lopez, Madhavi Reddy & Vinaya Gaduputi. (2021) Esophagitis Dissecans Superficialis (EDS) Secondary to Hair Dye Ingestion: Case Report and Literature Review. Clinics and Practice 11:2, pages 185-189.
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Stephen DePaul, Nicholas DelBuono & Muhammad Masood Khalid. (2021) Contact dermatitis from p-Phenylenediamine in beard dye. Visual Journal of Emergency Medicine 22, pages 100939.
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Gopalakrishnan Venkatesan, Yuri Dancik, Arup Sinha, Hpone Myint Kyaw, Ramasamy Srinivas, Thomas L. DawsonJr.Jr., Mei Bigliardi, Paul Bigliardi & Giorgia Pastorin. (2021) Development of novel alternative hair dyes to hazardous para-phenylenediamine. Journal of Hazardous Materials 402, pages 123712.
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Caterina Foti, Domenico Bonamonte, Paolo Romita, Fabrizio Guarneri, Cataldo Patruno & Gianni Angelini. 2021. Clinical Contact Dermatitis. Clinical Contact Dermatitis 437 497 .
Linda Piapan, Marcella Mauro, Chiara Martinuzzo & Francesca Larese Filon. (2020) Characteristics and incidence of contact dermatitis among hairdressers in north‐eastern Italy. Contact Dermatitis 83:6, pages 458-465.
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Victoria A. Perez, Mark A. Strom & Christine T. Lauren. (2020) Allergic Contact Dermatitis to a Henna Tattoo. The Journal of Emergency Medicine 59:4, pages e137-e138.
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Jae Kwon Lee, Hye Eun Lee, Gabsik Yang, Kyu-Bong Kim, Seung Jun Kwack & Joo Young Lee. (2020) Para-phenylenediamine, an oxidative hair dye ingredient, increases thymic stromal lymphopoietin and proinflammatory cytokines causing acute dermatitis. Toxicological Research 36:4, pages 329-336.
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Surabhi Sinha, Sweta Singh, Kabir Sardana & Purnima Malhotra. (2020) An uncommon case of systematized bullous contact dermatitis due to p ‐phenylenediamine healing with a “livedoid” pattern . Contact Dermatitis 83:3, pages 235-237.
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Dharam Persaud-Sharma, Marien Govea & Robert Hernandez. (2020) Mixed Bullous-Eczematous Contact Dermatitis From a Black Henna Tattoo in an African American Female With Sickle Cell Disease With Post-Dermatitis Pain. Cureus.
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M‐C. Wilmot & S. H. Wakelin. (2019) Allergic contact dermatitis caused by a jagua temporary tattoo. Clinical and Experimental Dermatology 45:2, pages 261-262.
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Haudrey Assier, Pierre Wolkenstein & Olivier Chosidow. (2019) Beard dermatitis induced by coloration. Contact Dermatitis 81:6, pages 471-473.
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Connie C. Qiu, Ashley E. Brown, Gabriella R. Lobitz, Akshay Shanker & Sylvia Hsu. (2019) The color of skin: black diseases of the skin, nails, and mucosa. Clinics in Dermatology 37:5, pages 447-467.
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A. Bishnoi, K. Vinay, Arshdeep, D. Parsad, S. Handa, U.N. Saikia & M. Sendhil Kumaran. (2019) Contact sensitization to hair colours in acquired dermal macular hyperpigmentation: results from a patch and photo‐patch test study of 108 patients. Journal of the European Academy of Dermatology and Venereology 33:7, pages 1349-1357.
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Evelyn O. Ojo, Asha Gowda & Susan Nedorost. (2019) Scalp Dermatitis in Patients Sensitized to Components of Hair Products. Dermatitis 30:4, pages 264-267.
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Matthew Zirwas & Hershel Dobkin. (2019) 2-Methoxymethyl-para-phenylenediamine–containing hair dye as a less allergenic alternative for para-phenylenediamine–allergic individuals. Journal of the American Academy of Dermatology 80:3, pages 775-777.
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Soo Myoung ShinYeonhee LeeHongran MoonSang-A KimJi Hyun OhSujie ChungJi Soo ShimHye-Ryun Kang. (2019) A case of hair dye-induced contact anaphylaxis. Allergy, Asthma & Respiratory Disease 7:4, pages 218.
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Anita Sivam & Mike Tankersley. (2019) Allergic Contact Dermatitis to Henna Tattoo with Negative Patch to p-phenylenediamine (PPD). The Journal of Allergy and Clinical Immunology: In Practice 7:1, pages 288-289.
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Anne H. Boyd, Amy J. Zhang & Sara A. Hylwa. (2018) Seeing Double: Allergic Contact Dermatitis to para-Amino Compounds. Dermatitis 29:5, pages 285-286.
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