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Review

Management of transfusional iron overload – differential properties and efficacy of iron chelating agents

Pages 135-149 | Published online: 21 Sep 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Sirinart Kumfu, Juthamas Khamseekaew, Siripong Palee, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C. Chattipakorn & Nipon Chattipakorn. (2018) A combination of an iron chelator with an antioxidant exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice. Free Radical Research 52:1, pages 70-79.
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Vip Viprakasit, Sarayuth Rodmai & Somdet Srichairatanakool. (2014) Deferiprone for transfusional iron overload and its roles in developing countries. Expert Opinion on Orphan Drugs 2:2, pages 189-200.
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Etheresia Pretorius, Natasha Vermeulen, Janette Bester, Boguslaw Lipinski & Douglas B. Kell. (2013) A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy. Toxicology Mechanisms and Methods 23:5, pages 352-359.
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Articles from other publishers (26)

Mihai Lupu, Camelia Alexandra Coada, Diana-Valentina Tudor, Ioana Baldea, Adrian Florea, Vlad-Alexandru Toma, Ana Lupsor, Remus Moldovan, Nicoleta Decea & Gabriela Adriana Filip. (2023) Iron chelation alleviates multiple pathophysiological pathways in a rat model of cardiac pressure overload. Free Radical Biology and Medicine 200, pages 1-10.
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Maria Daglas, Phan H. Truong, Linh Q. Miles, Sydney M. A. Juan, Shalini S. Rao & Paul A. Adlard. (2022) Deferiprone attenuates neuropathology and improves outcome following traumatic brain injury. British Journal of Pharmacology 180:2, pages 214-234.
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Lars Gerhardsson. 2022. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 663 684 .
Akram Bardestani, Shiva Ebrahimpour, Ali Esmaeili & Abolghasem Esmaeili. (2021) Quercetin attenuates neurotoxicity induced by iron oxide nanoparticles. Journal of Nanobiotechnology 19:1.
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Panagiotis Kompotiatis, Sandhya Manohar, Hassan B. Alkhateeb, William J. Hogan, Karl A. Nath & Nelson Leung. (2021) Hemoglobinuria in the Early Poststem-Cell–Transplant Period: Risk Factors and Association with Outcomes. Kidney360 2:10, pages 1569-1575.
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David Strum, Elina Kapoor, Timothy ShimSunny Kim, Parisa SabetrasekhAshkan Monfared. (2020) Prevalence of Sensorineural Hearing Loss in Pediatric Patients with Sickle Cell Disease: A Meta‐analysis. The Laryngoscope 131:5, pages 1147-1156.
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Andrew Jesse Garcia, Chikezie N. Okeagu, Alan David Kaye & Alaa Abd-Elsayed. 2021. Essentials of Blood Product Management in Anesthesia Practice. Essentials of Blood Product Management in Anesthesia Practice 289 299 .
Mario Caruffo, Dinka Mandakovic, Madelaine Mejías, Ignacio Chávez-Báez, Pablo Salgado, Daniela Ortiz, Liliana Montt, Javiera Pérez-Valenzuela, Francisca Vera-Tamargo, José Manuel Yánez, Jurij Wacyk & Rodrigo Pulgar. (2020) Pharmacological iron-chelation as an assisted nutritional immunity strategy against Piscirickettsia salmonis infection. Veterinary Research 51:1.
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Stephanie Yiu, Kwai Hui, Chung Choi, Richard Kao, Chi Ma, Dan Yang & Alan Chiang. (2018) Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers. Cancers 10:12, pages 505.
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Marco Nuñez & Pedro Chana-Cuevas. (2018) New Perspectives in Iron Chelation Therapy for the Treatment of Neurodegenerative Diseases. Pharmaceuticals 11:4, pages 109.
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Suwakon Wongjaikam, Sirinart Kumfu, Juthamas Khamseekaew, Siriporn C. Chattipakorn & Nipon Chattipakorn. (2017) Restoring the impaired cardiac calcium homeostasis and cardiac function in iron overload rats by the combined deferiprone and N-acetyl cysteine. Scientific Reports 7:1.
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Jirapas Sripetchwandee, Suwakon Wongjaikam, Warunsorn Krintratun, Nipon Chattipakorn & Siriporn C. Chattipakorn. (2016) A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload. Neuroscience 332, pages 191-202.
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Satoshi Ito, Katsuya Ikuta, Daisuke Kato, Addo Lynda, Kotoe Shibusa, Noriyasu Niizeki, Yasumichi Toki, Mayumi Hatayama, Masayo Yamamoto, Motohiro Shindo, Naomi Iizuka, Yutaka Kohgo & Mikihiro Fujiya. (2016) In vivo behavior of NTBI revealed by automated quantification system. International Journal of Hematology 104:2, pages 175-181.
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Hee Won Chueh. (2016) Treatment and Management of Late Complications in Hereditary Hemolytic Anemia. Clinical Pediatric Hematology-Oncology 23:1, pages 1-7.
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Mohsen S. Elalfy, Maha M. Saber, Amira Abdel Moneam Adly, Eman A. Ismail, Mohamed Tarif, Fatma Ibrahim & Omar M. Elalfy. (2016) Role of vitamin C as an adjuvant therapy to different iron chelators in young β-thalassemia major patients: efficacy and safety in relation to tissue iron overload. European Journal of Haematology 96:3, pages 318-326.
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Lars Gerhardsson & Jan Aaseth. 2016. Chelation Therapy in the Treatment of Metal Intoxication. Chelation Therapy in the Treatment of Metal Intoxication 313 341 .
Sidharth Totadri, Deepak Bansal, Prateek Bhatia, Savita V. Attri, Amita Trehan & R. K. Marwaha. (2015) The deferiprone and deferasirox combination is efficacious in iron overloaded patients with β-thalassemia major: A prospective, single center, open-label study. Pediatric Blood & Cancer 62:9, pages 1592-1596.
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Hatoon M. Ezzat, John Wu, Heather McCartney & Heather A. Leitch. (2015) Vitamin D Insufficiency and Liver Iron Concentration in Transfusion Dependent Hemoglobinopathies in British Columbia. Open Journal of Hematology 6, pages 1.
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Lars Gerhardsson & George Kazantzis. 2015. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 487 505 .
Yesim Aydinok, Antonis Kattamis & Vip Viprakasit. (2014) Current approach to iron chelation in children. British Journal of Haematology 165:6, pages 745-755.
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Samin AlaviElham SadeghiAzin Ashenagar. (2014) Efficacy and safety of combined oral iron chelation therapy with deferasirox and deferiprone in a patient with beta-thalassemia major and persistent iron overload. Blood Research 49:1, pages 72.
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Deepak Bansal & Sidharth Totadri. (2013) Common Hematological Disorders in Children. The Indian Journal of Pediatrics 81:1, pages 42-50.
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Dudley J. Pennell, James E. Udelson, Andrew E. Arai, Biykem Bozkurt, Alan R. Cohen, Renzo Galanello, Timothy M. Hoffman, Michael S. Kiernan, Stamatios Lerakis, Antonio Piga, John B. Porter, John Malcolm Walker & John Wood. (2013) Cardiovascular Function and Treatment in β-Thalassemia Major. Circulation 128:3, pages 281-308.
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Nicolas Leuenberger, Yorck Olaf Schumacher, Sylvain Pradervand, Thomas Sander, Martial Saugy & Torben Pottgiesser. (2013) Circulating microRNAs as Biomarkers for Detection of Autologous Blood Transfusion. PLoS ONE 8:6, pages e66309.
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Marcin Koba, Artur Słomka, Tomasz Bączek, Michał P. Marszałł & Ewa Żekanowska. (2013) Ability to determine the desferrioxamine-chelatable iron fractions of nontransferrin-bound iron using HPLC. Journal of Separation Science 36:4, pages 665-669.
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Kyle V. Lopin, I. Patrick Gray, Carlos A. Obejero-Paz, Frank Thévenod & Stephen W. Jones. (2012) Fe 2+ Block and Permeation of Ca V 3.1 (α1G) T-Type Calcium Channels: Candidate Mechanism for Non–Transferrin-Mediated Fe 2+ Influx . Molecular Pharmacology 82:6, pages 1194-1204.
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