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Review

First-line treatment of chronic myeloid leukemia with nilotinib: critical evaluation

Pier Paolo PiccalugaCorrespondence[email protected]

Stefania Paolini

Clara BertuzziHematopathology and Hematology Sections, Department of Hematology and Oncological Sciences, “L and A Seràgnoli”, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy

Antonio De LeoHematopathology and Hematology Sections, Department of Hematology and Oncological Sciences, “L and A Seràgnoli”, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy

Gianantonio RostiHematopathology and Hematology Sections, Department of Hematology and Oncological Sciences, “L and A Seràgnoli”, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy

Pages 151-156 | Published online: 29 Nov 2012

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Rodolfo Moreno-Fuquen, Kevin Arango-Daraviña & Alan R. Kennedy. (2021) Synthesis, spectroscopic characterization, structural studies, thermal analysis and molecular docking of N -(2-methyl-5-nitrophenyl)-4-(pyridin-2-yl)pyrimidin-2-amine, a precursor for drug design against chronic myeloid leukemia . Acta Crystallographica Section C Structural Chemistry 77:10, pages 621-632.
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Ahmed E. Goda, Alaa E. Elsisi, Samia S. Sokkar & Noha M. Abdelrazik. (2020) Enhanced in vivo targeting of estrogen receptor alpha signaling in murine mammary adenocarcinoma by nilotinib/rosuvastatin novel combination. Toxicology and Applied Pharmacology 404, pages 115185.
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Alane Pereira Cortez, Elizabeth Gomes Paulino Menezes, Polyana Lopes Benfica, Alexandre Pereira dos Santos, Larissa Moreira Cleres, Higor de Oliveira Ribeiro, Eliana Martins Lima, Massuo Jorge Kato & Marize Campos Valadares. (2017) Grandisin induces apoptosis in leukemic K562 cells. Brazilian Journal of Pharmaceutical Sciences 53:1.
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Giuseppe Tridente. 2017. Adverse Events and Oncotargeted Kinase Inhibitors. Adverse Events and Oncotargeted Kinase Inhibitors 265 281 .

Kalubai Vari Khajapeer & Rajasekaran Baskaran. (2015) Hsp90 Inhibitors for the Treatment of Chronic Myeloid Leukemia. Leukemia Research and Treatment 2015, pages 1-16.
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Shabneez Hussain & Mohammad Usman Shaikh. (2015) Response and Adverse Effects of Nilotinib in Imatinib-resistant Chronic Myeloid Leukemia Patients: Data From a Developing Country. Clinical Therapeutics 37:11, pages 2449-2457.
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Serdal Korkmaz, Mehmet Sinan Dal, Ilhami Berber, Deniz Goren Sahin, Mehmet Hilmi Dogu, Orhan Ayyildiz, Ilknur Nizam, Murat Albayrak, Ramazan Esen, Sinem Namdaroglu, Mehmet Sencan, Olga Meltem Akay, Sibel Hacioglu, Rahsan Yildirim, Ali Eser, Anil Tombak, Cigdem Pala & Osman Ilhan. (2015) Clinical characteristics and therapeutic outcomes of elderly patients with chronic myeloid leukemia: A retrospective multicenter study. Geriatrics & Gerontology International 15:6, pages 729-735.
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ASTRID M. PEDERSEN, SUSAN THRANE, ANNE E. LYKKESFELDT & CHRISTINA W. YDE. (2014) Sorafenib and nilotinib resensitize tamoxifen resistant breast cancer cells to tamoxifen treatment via estrogen receptor α. International Journal of Oncology 45:5, pages 2167-2175.
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Chika Kawajiri, Hiroaki Tanaka, Shinichiro Hashimoto, Yusuke Takeda, Shio Sakai, Toshiyuki Takagi, Masahiro Takeuchi, Chikako Ohwada, Emiko Sakaida, Naomi Shimizu & Chiaki Nakaseko. (2014) Successful treatment of Philadelphia chromosome-positive mixed phenotype acute leukemia by appropriate alternation of second-generation tyrosine kinase inhibitors according to BCR-ABL1 mutation status. International Journal of Hematology 99:4, pages 513-518.
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Huafeng Wang, Jie Jin, Yungui Wang, Xin Huang & Jian Huang. (2013) Clonal chromosomal abnormalities in Philadelphia-negative cells in chronic myeloid leukemia patients treated with nilotinib used in first-line therapy. Annals of Hematology 92:12, pages 1625-1632.
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ZHENSHENG DAI, WEIZHONG XIAO & YUELING JIN. (2013) Inhibition of nm23-H1 gene expression in chronic myelogenous leukemia cells. Oncology Letters 6:4, pages 1093-1097.
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Ciani Oriana, Hoyle Martin, Pavey Toby, Cooper Chris, Garside Ruth, Rudin Claudius & Taylor Rod. (2013) Complete Cytogenetic Response and Major Molecular Response as Surrogate Outcomes for Overall Survival in First-Line Treatment of Chronic Myelogenous Leukemia: A Case Study for Technology Appraisal on the Basis of Surrogate Outcomes Evidence. Value in Health 16:6, pages 1081-1090.
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First-line treatment of chronic myeloid leukemia with nilotinib: critical evaluation

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First-line treatment of chronic myeloid leukemia with nilotinib: critical evaluation

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