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Review

Treating thalassemia major-related iron overload: the role of deferiprone

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Pages 119-129 | Published online: 19 Oct 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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Hadi Darvishi-Khezri, Mohammad Naderisorki, Mohammad Zahedi, Parham Mortazavi, Fatemeh Tajik, Amirreza Nasirzadeh & Hossein Karami. (2021) Coadministration of silymarin with iron chelators in transfusion-dependent β-thalassemia patients: a systematic review and meta-analysis for effect on iron overload. Expert Review of Clinical Pharmacology 14:11, pages 1445-1453.
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Malihe Nourollahpour Shiadeh, Elena Cassinerio, Maryam Modarres, Armin Zareiyan, Zeinab Hamzehgardeshi & Zahra Behboodi Moghadam. (2020) Reproductive health issues in female patients with beta-thalassaemia major: a narrative literature review. Journal of Obstetrics and Gynaecology 40:7, pages 902-911.
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Sirinart Kumfu, Juthamas Khamseekaew, Siripong Palee, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C. Chattipakorn & Nipon Chattipakorn. (2018) A combination of an iron chelator with an antioxidant exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice. Free Radical Research 52:1, pages 70-79.
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Rajni Sharma, Anju Seth, Jagdish Chandra, Suraj Gohain, Seema Kapoor, Pratiksha Singh & Harish Pemde. (2016) Endocrinopathies in adolescents with thalassaemia major receiving oral iron chelation therapy. Paediatrics and International Child Health 36:1, pages 22-27.
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Vip Viprakasit, Sarayuth Rodmai & Somdet Srichairatanakool. (2014) Deferiprone for transfusional iron overload and its roles in developing countries. Expert Opinion on Orphan Drugs 2:2, pages 189-200.
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Articles from other publishers (28)

Mohammmed Al Blooshi, Mustafa Hamchou & Ahmed AlSalem. (2023) Duodenal perforation caused by deferasirox “case report”. Journal of Pediatric Surgery Case Reports 94, pages 102653.
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Tanuka Barua, Kawsar Sultana, Dazy Barua, Rifat Karnain, Showrov Barua Chowdhury & Mahmood A. Chowdhury Arzu. (2022) Expenditure to Treat Thalassemia- A Major Financial Burden. European Journal of Medical and Health Sciences 4:5, pages 52-56.
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Bita Behrouzi, Jill J. Weyers, Xiuling Qi, Jennifer Barry, Vrajlal Rabadia, Dino Manca, John Connelly, Michael Spino, John C. Wood, Bradley H. Strauss, Graham A. Wright & Nilesh R. Ghugre. (2020) Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction. Basic Research in Cardiology 115:3.
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Shaojun Yun, Dongyang Chu, Xingshuai He, Wenfang Zhang & Cuiping Feng. (2020) Protective effects of grape seed proanthocyanidins against iron overload-induced renal oxidative damage in rats. Journal of Trace Elements in Medicine and Biology 57, pages 126407.
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Jirapas Sripetchwandee, Juthamas Khamseekaew, Saovaros Svasti, Somdet Srichairatanakool, Suthat Fucharoen, Nipon Chattipakorn & Siriporn C. Chattipakorn. (2019) Deferiprone and efonidipine mitigated iron-overload induced neurotoxicity in wild-type and thalassemic mice. Life Sciences 239, pages 116878.
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Ananda Kumar Konreddy, Grandhe Usha Rani, Kyeong Lee & Yongseok Choi. (2019) Recent Drug-Repurposing-Driven Advances in the Discovery of Novel Antibiotics. Current Medicinal Chemistry 26:28, pages 5363-5388.
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Maria Domenica Cappellini, John B. Porter, Vip Viprakasit & Ali T. Taher. (2018) A paradigm shift on beta-thalassaemia treatment: How will we manage this old disease with new therapies?. Blood Reviews 32:4, pages 300-311.
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Ari EstuningtyasKlaus ZwickerTri WahyuniPurnama FajriPustika Amalia WahidiyatSeruni K.U. FreislebenHans-Joachim Freisleben. (2018) Are Mangiferin and Mangiferin-Containing Plant Extracts Helpful for Iron-Loaded Transfusion-Dependent and Non-Transfusion-Dependent Thalassaemia Patients?. Biomedical and Pharmacology Journal 11:1, pages 29-43.
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Sirinart Kumfu, Juthamas Khamseekaew, Siripong Palee, Somdet Srichairatanakool, Suthat Fucharoen, Siriporn C. Chattipakorn & Nipon Chattipakorn. (2018) Combined iron chelator and T-type calcium channel blocker exerts greater efficacy on cardioprotection than monotherapy in iron-overload thalassemic mice. European Journal of Pharmacology 822, pages 43-50.
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Chunbo Zou, Xiaogang Liu, Rujuan Xie, Yushi Bao, Qing Jin, Xibei Jia, Li Li & Ruichan Liu. (2017) Deferiprone attenuates inflammation and myocardial fibrosis in diabetic cardiomyopathy rats. Biochemical and Biophysical Research Communications 486:4, pages 930-936.
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John Porter. 2016. Metal Chelation in Medicine. Metal Chelation in Medicine 106 152 .
Michael D. Diamantidis, Nikolaos Neokleous, Aleka Agapidou, Evaggelia Vetsiou, Achilles Manafas, Paraskevi Fotiou & Efthymia Vlachaki. (2016) Iron chelation therapy of transfusion-dependent β-thalassemia during pregnancy in the era of novel drugs: is deferasirox toxic?. International Journal of Hematology 103:5, pages 537-544.
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Sirinart Kumfu, Siriporn C. Chattipakorn, Suthat Fucharoen & Nipon Chattipakorn. (2016) Dual T-type and L-type calcium channel blocker exerts beneficial effects in attenuating cardiovascular dysfunction in iron-overloaded thalassaemic mice. Experimental Physiology 101:4, pages 521-539.
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Mohsen S. Elalfy, Amira M Adly, Yasser Wali, Samir Tony, Ahmad Samir & Yasmine I. Elhenawy. (2015) Efficacy and safety of a novel combination of two oral chelators deferasirox/deferiprone over deferoxamine/deferiprone in severely iron overloaded young beta thalassemia major patients. European Journal of Haematology 95:5, pages 411-420.
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Nupur Parakh, Rajni Sharma, Om Prakash, DeoNath Mahto, Bhavna Dhingra, Suvasini Sharma & Jagdish Chandra. (2015) Neurological Complications and Cataract in a Child With Thalassemia Major Treated With Deferiprone. Journal of Pediatric Hematology/Oncology 37:7, pages e433-e434.
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Ying Zhang, Hao Wang, Lijing Cui, Yuanyuan Zhang, Yang Liu, Xi Chu, Zhenyi Liu, Jianping Zhang & Li Chu. (2015) Continuing Treatment with Salvia miltiorrhiza Injection Attenuates Myocardial Fibrosis in Chronic Iron-Overloaded Mice. PLOS ONE 10:4, pages e0124061.
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Amin Abolhasani Foroughi, Hosein Ghaffari, Sezaneh Haghpanah, Masoume Nazeri, Roghieh Ghaffari, Marzieh Bardestani & Mehran Karimi. (2015) Comparative Study of Radiographic and Laboratory Findings Between Beta Thalassemia Major and Beta Thalassemia Intermedia Patients With and Without Treatment by Hydroxyurea. Iranian Red Crescent Medical Journal 17:2.
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Orn-uma Yanpanitch, Suneerat Hatairaktham, Ratiya Charoensakdi, Narumol Panichkul, Suthat Fucharoen, Somdet Srichairatanakool, Noppadol Siritanaratkul & Ruchaneekorn W. Kalpravidh. (2015) Treatment of β -Thalassemia/Hemoglobin E with Antioxidant Cocktails Results in Decreased Oxidative Stress, Increased Hemoglobin Concentration, and Improvement of the Hypercoagulable State . Oxidative Medicine and Cellular Longevity 2015, pages 1-8.
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A. Kyriakou & N. Skordis. 2015. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Raymond J. Bergeron, Jan Wiegand, James S. McManis & Neelam Bharti. (2014) Desferrithiocin: A Search for Clinically Effective Iron Chelators. Journal of Medicinal Chemistry 57:22, pages 9259-9291.
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Thomas D. Coates. (2014) Physiology and pathophysiology of iron in hemoglobin-associated diseases. Free Radical Biology and Medicine 72, pages 23-40.
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Joshua P. Gray & Sidhartha D. Ray. 2014. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 323 337 .
Chunbo Zou, Rujuan Xie, Yushi Bao, Xiaogang Liu, Manshu Sui, Suhong M, Shuang Li & Huiqing Yin. (2013) Iron chelator alleviates tubulointerstitial fibrosis in diabetic nephropathy rats by inhibiting the expression of tenascinC and other correlation factors. Endocrine 44:3, pages 666-674.
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Rajni Sharma, Rama Anand, Jagdish Chandra, Anju Seth, Harish Pemde & Varinder Singh. (2013) Distal ulnar changes in children with thalassemia and deferiprone related arthropathy. Pediatric Blood & Cancer 60:12, pages 1957-1962.
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Elizabeth C. Theil. (2013) Ferritin: The Protein Nanocage and Iron Biomineral in Health and in Disease. Inorganic Chemistry 52:21, pages 12223-12233.
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Shengjiang Guan, Juanjuan Ma, Ying Zhang, Yonggang Gao, Yuanyuan Zhang, Xuan Zhang, Na Wang, Yun Xie, Jiangyan Wang, Jianping Zhang & Li Chu. (2013) Danshen (Salvia miltiorrhiza) Injection Suppresses Kidney Injury Induced by Iron Overload in Mice. PLoS ONE 8:9, pages e74318.
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