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Journal of Experimental Pharmacology Volume 12, 2020 - Issue
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Original Research

Chemically-Modified Curcumin 2.24: A Novel Systemic Therapy for Natural Periodontitis in Dogs

Jie Deng1 Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY11794, USACorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1048-8762
ORCID Icon,
Lorne M Golub1 Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY11794, USA
,
Hsi-Ming Lee1 Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY11794, USA
,
Michael C Lin1 Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY11794, USA
,
Heta Dinesh Bhatt1 Department of Oral Biology and Pathology, School of Dental Medicine, Stony Brook University, Stony Brook, NY11794, USAORCID Iconhttps://orcid.org/0000-0001-8934-3779
ORCID Icon,
Hou-Lin Hong2 Department of Public Health, School of Medicine, Stony Brook University, Stony Brook, NY11794, USA
,
Francis Johnson3 Department of Chemistry and Pharmacological Sciences, School of Medicine, Stony Brook University, Stony Brook, NY11794, USA
,
Joseph Scaduto4 Traverse Biosciences, Inc., Stony Brook, NY11790, USAORCID Iconhttps://orcid.org/0000-0003-2295-9047
ORCID Icon,
Thomas Zimmerman5 Division of Laboratory Animal Resources (DLAR) at Stony Brook, Stony Brook University, Stony Brook, NY11794, USAORCID Iconhttps://orcid.org/0000-0001-9517-3294
ORCID Icon &
Ying Gu6 Department of General Dentistry, School of Dental Medicine, Stony Brook University, Stony Brook, NY11794, USA
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Pages 47-60 | Published online: 10 Feb 2020

Citations (17)

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Read on this site (4)

Heta Dinesh Bhatt, Lorne M Golub, Hsi-Ming Lee, Jihwan Kim, Thomas Zimmerman, Jie Deng, Houlin Hong, Francis Johnson & Ying Gu. (2023) Efficacy of a Novel Pleiotropic MMP-Inhibitor, CMC2.24, in a Long-Term Diabetes Rat Model with Severe Hyperglycemia-Induced Oral Bone Loss. Journal of Inflammation Research 16, pages 779-792.
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Heta Dinesh Bhatt, Steve A McClain, Hsi-Ming Lee, Thomas Zimmerman, Jie Deng, Francis Johnson, Ying Gu & Lorne M Golub. (2022) The Maximum-Tolerated Dose and Pharmacokinetics of a Novel Chemically Modified Curcumin in Rats. Journal of Experimental Pharmacology 14, pages 73-85.
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Jie Deng, Lorne M Golub, Hsi-Ming Lee, Veena Raja, Francis Johnson, Allan Kucine, Wonsae Lee, Tian-Min Xu & Ying Gu. (2021) A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis. Journal of Inflammation Research 14, pages 5337-5347.
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Esam Dhaifullah, Hassan S Seayed, Diana Mostafa, Abdul Majeed M Alharbi & Waleed M Alotaibi. (2021) Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review. Journal of Experimental Pharmacology 13, pages 565-575.
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Articles from other publishers (13)

Xiaowei Liu, Lei Yang & Xuelian Tan. (2023) PD-1/PD-L1 pathway: A double-edged sword in periodontitis. Biomedicine & Pharmacotherapy 159, pages 114215.
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Fathia Agzarine Deandra, Ketherin Ketherin, Rieska Rachmasari, Benso Sulijaya & Naoki Takahashi. (2023) Probiotics and metabolites regulate the oral and gut microbiome composition as host modulation agents in periodontitis: A narrative review. Heliyon 9:2, pages e13475.
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Md Mahamudul Haque, Katherine Yerex, Anastasia Kelekis-Cholakis & Kangmin Duan. (2022) Advances in novel therapeutic approaches for periodontal diseases. BMC Oral Health 22:1.
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Tracey Lynn Harney. 2022. Oral Health Care - An Important Issue of the Modern Society. Oral Health Care - An Important Issue of the Modern Society.
Thuraya Elgreu, Sean Lee, Sabrina Wen, Radwa Elghadafi, Thanarut Tangkham, Yun Ma, Bing Liu, Serge Dibart & Xiaoren Tang. (2021) The pathogenic mechanism of oral bacteria and treatment with inhibitors. Clinical and Experimental Dental Research 8:1, pages 439-448.
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Ying Gu, Veena Raja, Hsi-Ming Lee, Houlin Hong, Glenn Prestwich & Maria E. Ryan. (2021) Therapeutic potential of a novel semi-synthetic-sulfated-polysaccharide to suppress inflammatory mediators in P. gingivalis LPS stimulated human monocytes/macrophages. Journal of Inflammation 18:1.
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Bo Yang, Xuefei Pang, Zhipeng Li, Zhuofan Chen & Yan Wang. (2021) Immunomodulation in the Treatment of Periodontitis: Progress and Perspectives. Frontiers in Immunology 12.
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Yongli Li, Junjie Jiao, Yuanzheng Qi, Wanqi Yu, Shihui Yang, Jingjie Zhang & Jinghui Zhao. (2021) Curcumin: A review of experimental studies and mechanisms related to periodontitis treatment. Journal of Periodontal Research 56:5, pages 837-847.
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Shilpi Goenka, Francis Johnson & Sanford R. Simon. (2021) Novel Chemically Modified Curcumin (CMC) Derivatives Inhibit Tyrosinase Activity and Melanin Synthesis in B16F10 Mouse Melanoma Cells. Biomolecules 11:5, pages 674.
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Sosmitha Girisa, Aviral Kumar, Varsha Rana, Dey Parama, Uzini Devi Daimary, Saman Warnakulasuriya, Alan Prem Kumar & Ajaikumar B. Kunnumakkara. (2021) From Simple Mouth Cavities to Complex Oral Mucosal Disorders—Curcuminoids as a Promising Therapeutic Approach. ACS Pharmacology & Translational Science 4:2, pages 647-665.
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Jie Deng, Lorne M. Golub, Hsi-Ming Lee, Heta-Dinesh Bhatt, Hou-Lin Hong, Francis Johnson, Joseph Scaduto, Thomas Zimmerman & Ying Gu. (2021) A Novel Chemically-Modified Curcumin 2.24: Short-Term Systemic Therapy for Natural Periodontitis in Dogs. Frontiers in Dental Medicine 2.
Crossref
Christian Bailly. (2020) The implication of the PD-1/PD-L1 checkpoint in chronic periodontitis suggests novel therapeutic opportunities with natural products. Japanese Dental Science Review 56:1, pages 90-96.
Crossref
Yan Zhou, Jianghua Ming, Ming Deng, Yaming Li, Bochun Li, Jia Li, Yonggang Ma, Zhonghui Chen, Guirong Wang & Shiqing Liu. (2020) Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. Journal of Molecular Medicine 98:10, pages 1479-1491.
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