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Journal of Experimental Pharmacology Volume 13, 2021 - Issue

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Investigational Rho Kinase Inhibitors for the Treatment of Glaucoma

Ghadeer Al-Humimat1 Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA;2 Department of Ophthalmology, King Hussein Medical Center, Amman, Jordan

Ibtisam Marashdeh2 Department of Ophthalmology, King Hussein Medical Center, Amman, Jordan

https://orcid.org/0000-0002-8136-6957

Duaa Daradkeh2 Department of Ophthalmology, King Hussein Medical Center, Amman, Jordan

Karanjit Kooner1 Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA;3 Department of Ophthalmology, Veteran Affairs North Texas Health Care System Medical Center Dallas, Dallas, TX, USACorrespondence[email protected]

https://orcid.org/0000-0002-2797-1750

Pages 197-212 | Published online: 25 Feb 2021

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Alexander M. Efremov, Olga V. Beznos, Roman O. Eremeev, Natalia B. Chesnokova, Elena R. Milaeva, Elena F. Shevtsova & Natalia A. Lozinskaya. (2023) Microwave-Assisted Synthesis of 3-Hydroxy-2-oxindoles and Pilot Evaluation of Their Antiglaucomic Activity. International Journal of Molecular Sciences 24:6, pages 5101.
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Kun-Che Chang, Pei-Feng Liu, Chia-Hsuan Chang, Ying-Cheng Lin, Yen-Ju Chen & Chih-Wen Shu. (2022) The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases. Cell & Bioscience 12:1.
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Yiming Wang, Yuqing Zhang & Dingguo Zhang. 2022. Frontiers in Cardiovascular Drug Discovery: Volume 6. Frontiers in Cardiovascular Drug Discovery: Volume 6 54 101 .

Nisha M Thomas & Prachi Nagrale. (2022) Rho Kinase Inhibitors as a Neuroprotective Pharmacological Intervention for the Treatment of Glaucoma. Cureus.
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Mona Bhargava, Surajit Sen, Varsha Bhambhani, RajShekhar Paul & Chandana Dutta. (2022) Reticular epithelial corneal edema as a novel side-effect of Rho Kinase Inhibitors: An Indian scenario. Indian Journal of Ophthalmology 70:4, pages 1163.
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. 2022. Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics. Handbook of Basic and Clinical Ocular Pharmacology and Therapeutics 67 89 .

Raphael Mietzner, Ramona Pawlak, Ernst R. Tamm, Achim Goepferich, Rudolf Fuchshofer & Miriam Breunig. (2021) Angiopoietin-1 Mimetic Nanoparticles for Restoring the Function of Endothelial Cells as Potential Therapeutic for Glaucoma. Pharmaceuticals 15:1, pages 18.
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Olmo Martín-Cámara, Ángel Cores, Pilar López-Alvarado & J. Carlos Menéndez. (2021) Emerging targets in drug discovery against neurodegenerative diseases: Control of synapsis disfunction by the RhoA/ROCK pathway. European Journal of Medicinal Chemistry 225, pages 113742.
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Da-Sol KuenMiso ParkHeeju RyuGaram ChoiYoung-Hye Moon, Jae-Ouk KimKeon Wook KangSang Geon Kim & Yeonseok Chung. (2021) Critical regulation of follicular helper T cell differentiation and function by Gα 13 signaling . Proceedings of the National Academy of Sciences 118:43.
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Huma Quadir, Knkush Hakobyan, Mrunanjali Gaddam, Ugochi Ojinnaka, Zubayer Ahmed, Amudhan Kannan & Jihan A Mostafa. (2021) Role of Rho-Associated Protein Kinase Inhibition As Therapeutic Strategy for Parkinson’s Disease: Dopaminergic Survival and Enhanced Mitophagy. Cureus.
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Yingyu Mao & Silvia C. Finnemann. (2021) Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK. Cells 10:8, pages 1927.
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Yosuke Ida, Megumi Watanabe, Hiroshi Ohguro & Fumihito Hikage. (2021) Simultaneous Use of ROCK Inhibitors and EP2 Agonists Induces Unexpected Effects on Adipogenesis and the Physical Properties of 3T3-L1 Preadipocytes. International Journal of Molecular Sciences 22:9, pages 4648.
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Akiyoshi Uemura & Yoko Fukushima. (2021) Rho GTPases in Retinal Vascular Diseases. International Journal of Molecular Sciences 22:7, pages 3684.
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Investigational Rho Kinase Inhibitors for the Treatment of Glaucoma

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