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Journal of Experimental Pharmacology Volume 12, 2020 - Issue
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Review

Long-Acting Muscarinic Antagonists Under Investigational to Treat Chronic Obstructive Pulmonary Disease

Josuel Ora1 Division of Respiratory Medicine, University Hospital Tor Vergata, Rome, ItalyCorrespondence[email protected]
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,
Angelo Coppola2 Division of Respiratory Medicine, San Filippo Neri Hospital, Rome, ItalyView further author information
,
Mario Cazzola3 Department of Experimental Medicine, University of Rome Tor Vergata, Rome, ItalyORCID Iconhttps://orcid.org/0000-0003-4895-9707View further author information
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Luigino Calzetta4 Department of Medicine and Surgery, Respiratory Disease and Lung Function Unit, University of Parma, Parma, ItalyORCID Iconhttps://orcid.org/0000-0003-0456-069XView further author information
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Paola Rogliani1 Division of Respiratory Medicine, University Hospital Tor Vergata, Rome, Italy;3 Department of Experimental Medicine, University of Rome Tor Vergata, Rome, ItalyORCID Iconhttps://orcid.org/0000-0001-7801-5040View further author information
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Pages 559-574 | Published online: 08 Dec 2020

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Maria Gabriella Matera, Barbara Rinaldi, Luigino Calzetta, Paola Rogliani & Mario Cazzola. (2023) Advances in adrenergic receptors for the treatment of chronic obstructive pulmonary disease: 2023 update. Expert Opinion on Pharmacotherapy 0:0, pages 1-10.
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Luigino Calzetta, Elena Pistocchini, Alfredo Chetta, Paola Rogliani & Mario Cazzola. (2023) Experimental drugs in clinical trials for COPD: artificial intelligence via machine learning approach to predict the successful advance from early-stage development to approval. Expert Opinion on Investigational Drugs 32:6, pages 525-536.
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Paola Rogliani, Francesco Cavalli, Alfredo Chetta, Mario Cazzola & Luigino Calzetta. (2022) Potential Drawbacks of ICS/LABA/LAMA Triple Fixed-Dose Combination Therapy in the Treatment of Asthma: A Quantitative Synthesis of Safety Profile. Journal of Asthma and Allergy 15, pages 565-577.
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Articles from other publishers (9)

Felisbela Gomes & Shih-Lung Cheng. (2023) Pathophysiology, Therapeutic Targets, and Future Therapeutic Alternatives in COPD: Focus on the Importance of the Cholinergic System. Biomolecules 13:3, pages 476.
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Tuleen Alkawadri, Pei Yee Wong, Zhihui Fong, Fionnuala T Lundy, Lorcan P McGarvey, Mark A Hollywood, Keith D Thornbury & Gerard P Sergeant. (2022) M2 Muscarinic Receptor-Dependent Contractions of Airway Smooth Muscle are Inhibited by Activation of β-Adrenoceptors. Function 3:6.
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Laura Carzaniga, Ian D. Linney, Andrea Rizzi, Maurizio Delcanale, Wolfgang Schmidt, Christopher K. Knight, Fiorella Pastore, Daniela Miglietta, Chiara Carnini, Nicola Cesari, Benedetta Riccardi, Valentina Mileo, Luca Venturi, Elisa Moretti, Wesley P. Blackaby, Riccardo Patacchini, Alessandro Accetta, Matteo Biagetti, Franco Bassani, Marina Tondelli, Annalisa Murgo, Loredana Battipaglia, Gino Villetti, Paola Puccini, Silvia Catinella, Maurizio Civelli & Fabio Rancati. (2022) Discovery of Clinical Candidate CHF-6366: A Novel Super-soft Dual Pharmacology Muscarinic Antagonist and β 2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases . Journal of Medicinal Chemistry 65:15, pages 10233-10250.
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Luigino Calzetta, Beatrice Ludovica Ritondo, Maria Cristina Zappa, Gian Marco Manzetti, Andrea Perduno, Janis Shute & Paola Rogliani. (2022) The impact of long-acting muscarinic antagonists on mucus hypersecretion and cough in chronic obstructive pulmonary disease: a systematic review. European Respiratory Review 31:164, pages 210196.
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Dave Singh, Jutta Beier, Carol Astbury, Maria G. Belvisi, Carla A. Da Silva, Alexandra Jauhiainen, Eulalia Jimenez, Alejhandra Lei, Sofia Necander, Jaclyn A. Smith, Ulrika Wählby Hamrén, Wenjing Xin & Ioannis Psallidas. (2022) The novel bronchodilator navafenterol: a phase 2a, multicentre, randomised, double-blind, placebo-controlled crossover trial in COPD. European Respiratory Journal 59:4, pages 2100972.
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Mario Cazzola, Paola Rogliani & Maria Gabriella Matera. (2022) The Future of Bronchodilators in COPD and Asthma. Archivos de Bronconeumología 58:2, pages 107-108.
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Mario Cazzola, Josuel Ora, Luigino Calzetta, Paola Rogliani & Maria Gabriella Matera. (2022) The future of inhalation therapy in chronic obstructive pulmonary disease. Current Research in Pharmacology and Drug Discovery 3, pages 100092.
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Lveli Wang, Chuang Xiao, Yaping Liang, Zhiying Weng & Weimin Yang. (2021) Research Advances in COPD Drugs and Novel Targets. Nano LIFE 11:03, pages 2140008.
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Fabio Rancati, Ian D. Linney, Andrea Rizzi, Maurizio Delcanale, Chris K. Knight, Wolfgang Schmidt, Fiorella Pastore, Benedetta Riccardi, Valentina Mileo, Chiara Carnini, Nicola Cesari, Wesley P. Blackaby, Riccardo Patacchini & Laura Carzaniga. (2021) Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD). Bioorganic & Medicinal Chemistry Letters 41, pages 127975.
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