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Journal of Hepatocellular Carcinoma Volume 8, 2021 - Issue
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Original Research

CYP2C8 Suppress Proliferation, Migration, Invasion and Sorafenib Resistance of Hepatocellular Carcinoma via PI3K/Akt/p27kip1 Axis

Xin Zhou1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaView further author information
,
Tian-Man Li1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;3 Department of Hepatobiliary Surgery, The Sixth Affiliated Hospital of Guangxi Medical University, Yulin, 537000, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-4397-6663View further author information
ORCID Icon,
Jian-Zhu Luo1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-5088-8007View further author information
ORCID Icon,
Chen-Lu Lan1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaView further author information
,
Zhong-Liu Wei1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaView further author information
,
Tian-Hao Fu1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaView further author information
,
Xi-Wen Liao1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-1724-1463View further author information
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Guang-Zhi Zhu1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaView further author information
,
Xin-Ping Ye1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaView further author information
&
Tao Peng1 Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of China;2 Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, Guangxi Zhuang Autonomous Region, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6133-7078View further author information
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Pages 1323-1338 | Published online: 03 Nov 2021

Citations (7)

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Jiang Guo, Wei Li, Long Cheng & Xuesong Gao. (2022) Identification and Validation of Hub Genes with Poor Prognosis in Hepatocellular Carcinoma by Integrated Bioinformatical Analysis. International Journal of General Medicine 15, pages 3933-3941.
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Articles from other publishers (6)

Li Gu, Xin Jin, Huaiyuan Liang, Chong Yang & Yu Zhang. (2023) Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex. Pharmacological Research 192, pages 106789.
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Domenico Iacopetta, Jessica Ceramella, Alessia Catalano, Elisabetta Scali, Domenica Scumaci, Michele Pellegrino, Stefano Aquaro, Carmela Saturnino & Maria Stefania Sinicropi. (2023) Impact of Cytochrome P450 Enzymes on the Phase I Metabolism of Drugs. Applied Sciences 13:10, pages 6045.
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Mahshid Deldar Abad Paskeh, Fatemeh Ghadyani, Mehrdad Hashemi, Alireza Abbaspour, Amirhossein Zabolian, Salar Javanshir, Mehrnaz Razzazan, Sepideh Mirzaei, Maliheh Entezari, Mohammad Ali Shekhi Beig Goharrizi, Shokooh Salimimoghadam, Amir Reza Aref, Alireza Kalbasi, Romina Rajabi, Mohsen Rashidi, Afshin Taheriazam & Gautam Sethi. (2023) Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges. Pharmacological Research 187, pages 106553.
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Mehrdad Hashemi, Sepideh Mirzaei, Mohammad Arad Zandieh, Sahar Rezaei, Amirabbas kakavand, Amir Dehghanpour, Negin Esmaeili, Azin Ghahremanzade, Hamidreza Saebfar, Hajar Heidari, Shokooh Salimimoghadam, Afshin Taheriazam, Maliheh Entezari & Kwang Seok Ahn. (2023) Long non-coding RNAs (lncRNAs) in hepatocellular carcinoma progression: Biological functions and new therapeutic targets. Progress in Biophysics and Molecular Biology 177, pages 207-228.
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Xin Zhou, Jianzhu Luo, Haixiang Xie, Zhongliu Wei, Tianman Li, Junqi Liu, Xiwen Liao, Guangzhi Zhu & Tao Peng. (2022) MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling. Cell Death Discovery 8:1.
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Bo Wang, Mengyan Li, Anna Su, Yongmei Gao, Yan Shi, Chao Li, Wenying Liu, Liping Su, Wan Li & Yuqing Ma. (2022) Prognostic Value of GPNMB, EGFR, p-PI3K, and Ki-67 in Patients with Esophageal Squamous Cell Carcinoma. Analytical Cellular Pathology 2022, pages 1-16.
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