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Review

The two faces of pannexins: new roles in inflammation and repair

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Pages 273-288 | Published online: 21 Jun 2018

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Anne Caufriez, Denise Böck, Charlotte Martin, Steven Ballet & Mathieu Vinken. (2020) Peptide-based targeting of connexins and pannexins for therapeutic purposes. Expert Opinion on Drug Discovery 15:10, pages 1213-1222.
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Xuejiao Yang, Guiqiu Zhao, Junwei Yan, Rui Xu, Chengye Che, Hengrui Zheng, Guoqiang Zhu & Jie Zhang. (2019) Pannexin 1 Channels Contribute to IL-1β Expression via NLRP3/Caspase-1 Inflammasome in Aspergillus Fumigatus Keratitis. Current Eye Research 44:7, pages 716-725.
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Articles from other publishers (29)

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Olga M. Rusiecka, Malaury Tournier, Filippo Molica & Brenda R. Kwak. (2022) Pannexin1 channels—a potential therapeutic target in inflammation. Frontiers in Cell and Developmental Biology 10.
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Benjamin Grimmer, Adrienn Krauszman, Xudong Hu, Golam Kabir, Kim A Connelly, Mei Li, Jana Grune, Christian Madry, Brant E Isakson & Wolfgang M Kuebler. (2022) Pannexin 1: a novel regulator of acute hypoxic pulmonary vasoconstriction. Cardiovascular Research 118:11, pages 2535-2547.
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Andrea V. Loureiro, Lauro I. Moura-Neto, Conceição S. Martins, Pedro I. M. Silva, Matheus B.S. Lopes, Renata F. C. Leitão, Juliana M. Coelho-Aguiar, Vivaldo Moura-Neto, Cirle A. Warren, Deiziane V.S. Costa & Gerly A. C. Brito. (2022) Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia. Frontiers in Immunology 13.
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Hong Yien Tan, Yean Kong Yong, Yuan Chao Xue, Huitao Liu, Tomomi Furihata, Esaki Muthu Shankar & Chen Seng Ng. (2022) cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model. iScience 25:6, pages 104404.
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Anne Caufriez, Andrés Tabernilla, Raf Van Campenhout, Axelle Cooreman, Kaat Leroy, Julen Sanz Serrano, Prashant Kadam, Bruna dos Santos Rodrigues, Arthur Lamouroux, Steven Ballet & Mathieu Vinken. (2022) Effects of Drugs Formerly Suggested for COVID-19 Repurposing on Pannexin1 Channels. International Journal of Molecular Sciences 23:10, pages 5664.
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Zakiye Nadeali, Fatemeh Mohammad-Rezaei, Hamid Aria & Parvaneh Nikpour. (2022) Possible role of pannexin 1 channels and purinergic receptors in the pathogenesis and mechanism of action of SARS-CoV-2 and therapeutic potential of targeting them in COVID-19. Life Sciences 297, pages 120482.
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Mark R. Zielinski & Allison J. Gibbons. (2022) Neuroinflammation, Sleep, and Circadian Rhythms. Frontiers in Cellular and Infection Microbiology 12.
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John Charles Rotondo, Chiara Mazziotta, Carmen Lanzillotti, Chiara Stefani, Giada Badiale, Giulia Campione, Fernanda Martini & Mauro Tognon. (2022) The Role of Purinergic P2X7 Receptor in Inflammation and Cancer: Novel Molecular Insights and Clinical Applications. Cancers 14:5, pages 1116.
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Cora L. Alvarez, María F. Troncoso & María V. Espelt. (2021) Extracellular ATP and adenosine in tumor microenvironment: Roles in epithelial–mesenchymal transition, cell migration, and invasion. Journal of Cellular Physiology 237:1, pages 389-400.
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Şefik Evren Erdener, Zeynep Kaya & Turgay Dalkara. (2021) Parenchymal neuroinflammatory signaling and dural neurogenic inflammation in migraine. The Journal of Headache and Pain 22:1.
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Dale W. Laird & Silvia Penuela. (2021) Pannexin biology and emerging linkages to cancer. Trends in Cancer 7:12, pages 1119-1131.
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Júlia Leão Batista Simões, Helena Fornari Basso, Greicy Cristine Kosvoski, Jullye Gavioli, Filomena Marafon, Charles Elias Assmann, Fabiano Barbosa Carvalho & Margarete Dulce Bagatini. (2021) Targeting purinergic receptors to suppress the cytokine storm induced by SARS-CoV-2 infection in pulmonary tissue. International Immunopharmacology 100, pages 108150.
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Katia Suarez-Berumen, Henry Collins-Hooper, Anastasia Gromova, Robyn Meech, Alessandra Sacco, Phil R. Dash, Robert Mitchell, Valery I. Shestopalov, Thomas E. Woolley, Sakthivel Vaiyapuri, Ketan Patel & Helen P. Makarenkova. (2021) Pannexin 1 Regulates Skeletal Muscle Regeneration by Promoting Bleb-Based Myoblast Migration and Fusion Through a Novel Lipid Based Signaling Mechanism. Frontiers in Cell and Developmental Biology 9.
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Juan C. Sanchez-Arias, Emma van der Slagt, Haley A. Vecchiarelli, Rebecca C. Candlish, Nicole York, Penelope A. Young, Olga Shevtsova, Afnan Juma, Marie-Ève Tremblay & Leigh Anne Swayne. (2021) Purinergic signaling in nervous system health and disease: Focus on pannexin 1. Pharmacology & Therapeutics 225, pages 107840.
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Garrett Rhodes, Kristen L. Segars, Yoonjoo K. Lee, Audrey E. K. Hutcheon, Celeste B. Rich & Vickery Trinkaus-Randall. (2021) Pannexin1: Role as a Sensor to Injury Is Attenuated in Pretype 2 Corneal Diabetic Epithelium. Analytical Cellular Pathology 2021, pages 1-9.
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Gonzalo Jorquera, Roberto Meneses-Valdés, Giovanni Rosales-Soto, Denisse Valladares-Ide, Cristian Campos, Mónica Silva-Monasterio, Paola Llanos, Gonzalo Cruz, Enrique Jaimovich & Mariana Casas. (2021) High extracellular ATP levels released through pannexin-1 channels mediate inflammation and insulin resistance in skeletal muscle fibres of diet-induced obese mice. Diabetologia 64:6, pages 1389-1401.
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Nariman Battulin, Vladimir M. Kovalzon, Alexey Korablev, Irina Serova, Oxana O. Kiryukhina, Marta G. Pechkova, Kirill A. Bogotskoy, Olga S. Tarasova & Yuri Panchin. (2021) Pannexin 1 Transgenic Mice: Human Diseases and Sleep-Wake Function Revision. International Journal of Molecular Sciences 22:10, pages 5269.
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XiaoXue Xu, YueHan Hao, Shuang Xiong & ZhiYi He. (2021) PANX2 and brain lower grade glioma genesis: A bioinformatic analysis. Science Progress 104:2, pages 003685042110118.
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Roberto Zefferino, Claudia Piccoli, Sante Di Gioia, Nazzareno Capitanio & Massimo Conese. (2021) How Cells Communicate with Each Other in the Tumor Microenvironment: Suggestions to Design Novel Therapeutic Strategies in Cancer Disease. International Journal of Molecular Sciences 22:5, pages 2550.
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Eijaz Ahmed Bhat & Nasreena Sajjad. (2021) Human Pannexin 1 channel: Insight in structure–function mechanism and its potential physiological roles. Molecular and Cellular Biochemistry 476:3, pages 1529-1540.
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Stuart B. Mazzone & Lorcan McGarvey. (2020) Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough. Clinical Pharmacology & Therapeutics 109:3, pages 619-636.
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Peipei Zhang, Masaki Ishikawa, Andrew Doyle, Takashi Nakamura, Bing He & Yoshihiko Yamada. (2021) Pannexin 3 regulates skin development via Epiprofin. Scientific Reports 11:1.
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Petra Kameritsch & Kristin Pogoda. (2020) The Role of Connexin 43 and Pannexin 1 During Acute Inflammation. Frontiers in Physiology 11.
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Zheng Ruan, Ian J. Orozco, Juan Du & Wei Lü. (2020) Structures of human pannexin 1 reveal ion pathways and mechanism of gating. Nature 584:7822, pages 646-651.
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Lianjiu Su, Xiaofang Jiang, Cheng Yang, Jiahao Zhang, Bo Chen, Yiming Li, Shijie Yao, Qin Xie, Hernando Gomez, Raghavan Murugan & Zhiyong Peng. (2019) Pannexin 1 mediates ferroptosis that contributes to renal ischemia/reperfusion injury. Journal of Biological Chemistry 294:50, pages 19395-19404.
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Michelle G. Shum, Qing Shao, Patrick Lajoie & Dale W. Laird. (2019) Destination and consequences of Panx1 and mutant expression in polarized MDCK cells. Experimental Cell Research 381:2, pages 235-247.
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