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Journal of Inflammation Research Volume 11, 2018 - Issue
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Review

Clinical utility of ustekinumab in Crohn’s disease

Paulo Gustavo Kotze1 Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;2 Inflammatory Bowel Disease Outpatient Clinics, Colorectal Surgery Unit, Catholic University of Paraná, Curitiba, BrazilCorrespondence[email protected]
,
Christopher Ma1 Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
,
Abdulelah Almutairdi1 Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada;3 Department of Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
&
Remo Panaccione1 Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
Pages 35-47 | Published online: 08 Feb 2018

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Christopher Ma, Vipul Jairath, Reena Khanna & Brian G. Feagan. (2018) Investigational drugs in phase I and phase II clinical trials targeting interleukin 23 (IL23) for the treatment of Crohn’s disease. Expert Opinion on Investigational Drugs 27:8, pages 649-660.
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Articles from other publishers (26)

Venkata Sai Harshabhargav Chenna, Talwinder K Nagi, Zoilo K Suarez, Oscar L Hernandez, Maymona E Nageye, Nafisa Reyaz, Ibrahim Reyaz & Neelum Ali. (2023) Comparison of Effectiveness and Safety of Ustekinumab and Adalimumab As Induction or Maintenance Therapy in Patients With Moderate to Severe Crohn's Disease: A Systematic Review and Meta-Analysis. Cureus.
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Justin Jacobse, Rachel E. Brown, Jing Li, Jennifer M. Pilat, Ly Pham, Sarah P. Short, Christopher T. Peek, Andrea Rolong, M. Kay Washington, Ruben Martinez-Barricarte, Mariana X. Byndloss, Catherine Shelton, Janet G. Markle, Yvonne L. Latour, Margaret M. Allaman, James E. Cassat, Keith T. Wilson, Yash A. Choksi, Christopher S. Williams, Ken S. Lau, Charles R. Flynn, Jean-Laurent Casanova, Edmond H.H.M. Rings, Janneke N. Samsom & Jeremy A. Goettel. (2023) Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells. Cell Reports 42:2, pages 112128.
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Jiayin Yao, Heng Zhang, Tao Su, Xiang Peng, Junzhang Zhao, Tao Liu, Wei Wang, Pinjin Hu, Min Zhi & Min Zhang. (2023) Ustekinumab Promotes Radiological Fistula Healing in Perianal Fistulizing Crohn’s Disease: A Retrospective Real-World Analysis. Journal of Clinical Medicine 12:3, pages 939.
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Paula Cenira Senger de CASTRO, Daniéla Oliveira MAGRO, Rodrigo Bremer NONES, Thaisa Kowalski FURLAN, Eron Fábio MIRANDA & Paulo Gustavo KOTZE. (2022) USTEKINUMAB IN CROHN’S DISEASE MANAGEMENT: A BRAZILIAN OBSERVATIONAL STUDY. Arquivos de Gastroenterologia 59:4, pages 501-507.
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Julio Maria Fonseca Chebli, Rogério Serafim Parra, Cristina Flores, Antonio Carlos Moraes, Rodrigo Bremer Nones, Tarcia Nogueira Ferreira Gomes, Ana Maria Bravo Perdomo, Gustavo Scapini & Cyrla Zaltman. (2022) Effectiveness and Safety of Ustekinumab for Moderate to Severely Active Crohn’s Disease: Results from an Early Access Program in Brazil. Journal of Clinical Medicine 11:21, pages 6481.
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Lauriane Galle-Treger, Doumet Georges Helou, Christine Quach, Emily Howard, Benjamin P. Hurrell, German R. Aleman Muench, Pedram Shafiei-Jahani, Jacob D. Painter, Andrea Iorga, Lily Dara, Juliet Emamaullee, Lucy Golden-Mason, Hugo R. Rosen, Pejman Soroosh & Omid Akbari. (2022) Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23. Nature Communications 13:1.
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Jeroen Geldof, Nusrat Iqbal, Janindra Warusavitarne & Ailsa Hart. (2022) The Essential Role of a Multidisciplinary Approach in Inflammatory Bowel Diseases: Combined Medical-Surgical Treatment in Complex Perianal Fistulas in CD. Clinics in Colon and Rectal Surgery 35:01, pages 021-031.
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Siddharth Singh, M Hassan Murad, Mathurin Fumery, Rocio Sedano, Vipul Jairath, Remo Panaccione, William J Sandborn & Christopher Ma. (2021) Comparative efficacy and safety of biologic therapies for moderate-to-severe Crohn's disease: a systematic review and network meta-analysis. The Lancet Gastroenterology & Hepatology 6:12, pages 1002-1014.
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Manrong He, Chao Li, Wanxin Tang, Yingxi Kang, Yongdi Zuo & Yufang Wang. (2021) Machine learning gene expression predicting model for ustekinumab response in patients with Crohn's disease. Immunity, Inflammation and Disease 9:4, pages 1529-1540.
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Rameshwar R. RaoFataneh MajlessipourDavid A. ZiringNicole M. Baca. (2021) Ewing's Sarcoma in a Patient with Crohn's Disease Treated with Ustekinumab: A Case Report. Journal of Adolescent and Young Adult Oncology 10:5, pages 614-617.
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Brecht Creyns, Inge Jacobs, Bram Verstockt, Jonathan Cremer, Vera Ballet, Roselien Vandecasteele, Tim Vanuytsel, Marc Ferrante, Séverine Vermeire, Gert Van Assche, Jan L. Ceuppens & Christine Breynaert. (2020) Biological Therapy in Inflammatory Bowel Disease Patients Partly Restores Intestinal Innate Lymphoid Cell Subtype Equilibrium. Frontiers in Immunology 11.
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Eva Espinosa-Cano, Maria Rosa Aguilar, Yadileiny Portilla, Domingo F. Barber & Julio San Román. (2020) Anti-Inflammatory Polymeric Nanoparticles Based on Ketoprofen and Dexamethasone. Pharmaceutics 12:8, pages 723.
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Markus F Neurath. (2020) COVID-19 and immunomodulation in IBD. Gut 69:7, pages 1335-1342.
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Isabel Pinto Pais, Maria C. Espinheira, Eunice Trindade & Jorge Amil Dias. (2020) Optimizing Antitumor Necrosis Factor Treatment in Pediatric Inflammatory Bowel Disease With Therapeutic Drug Monitoring. Journal of Pediatric Gastroenterology & Nutrition 71:1, pages 12-18.
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Eva Espinosa‐Cano, Maria Rosa Aguilar, Yadileiny Portilla, Domingo F. Barber & Julio San Román. (2020) Polymeric Nanoparticles that Combine Dexamethasone and Naproxen for the Synergistic Inhibition of Il12b Transcription in Macrophages . Macromolecular Bioscience 20:7, pages 2000002.
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Sebastián Eduardo Ibáñez Vodnizza, María Paz Poblete De La Fuente & Elisa Catalina Parra Cancino. (2020) Approach to the Patient with Axial Spondyloarthritis and Suspected Inflammatory Bowel Disease. Rheumatic Disease Clinics of North America 46:2, pages 275-286.
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Karma Yeshi, Roland Ruscher, Luke Hunter, Norelle L. Daly, Alex Loukas & Phurpa Wangchuk. (2020) Revisiting Inflammatory Bowel Disease: Pathology, Treatments, Challenges and Emerging Therapeutics Including Drug Leads from Natural Products. Journal of Clinical Medicine 9:5, pages 1273.
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Syedreza A. Haider, Abhijeet Yadav, Courtney Perry, Leon Su, Olalekan Akanbi, Praneeth Kudaravalli, Nishant Tripathi, Mahmoud A. Hashim, Mohammed Abdelsalam, Mohamed Hussein, Ahmed Elkheshen, Vihang Patel, Saad Emhmed Ali, Latoya Lamb, Karen Ingram, Casie Mayne, Amy B. Stuffelbeam, Deborah Flomenhoft, Arnold Stromberg & Terrence A. Barrett. (2020) Ustekinumab dose escalation improves clinical responses in refractory Crohn’s disease. Therapeutic Advances in Gastroenterology 13, pages 175628482095924.
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Abel Botelho Quaresma, Takayuki Yamamoto & Paulo Gustavo Kotze. (2020) Biologics and surgical outcomes in Crohn’s disease: is there a direct relationship?. Therapeutic Advances in Gastroenterology 13, pages 175628482093173.
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Daniela Migliarese Isaac & Eytan Wine. 2020. Encyclopedia of Gastroenterology. Encyclopedia of Gastroenterology 761 771 .
James B Haddow, Omar Musbahi, Thomas T MacDonald & Charles H Knowles. (2019) Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula. World Journal of Gastrointestinal Pathophysiology 10:4, pages 42-53.
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Markus F. Neurath. (2019) Resolution of inflammation: from basic concepts to clinical application. Seminars in Immunopathology 41:6, pages 627-631.
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Marjorie Argollo, Paulo Gustavo Kotze, Laura Lamonaca, Daniela Gilardi, Federica Furfaro, Takayuki Yamamoto & Silvio Danese. (2019) Prevention of Postoperative Recurrence in CD: Tailoring Treatment to Patient Profile. Current Drug Targets 20:13, pages 1327-1338.
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Georgia Kyriakou, Maria Gkermpesi, Konstantinos Thomopoulos, Markos Marangos & Sophia Georgiou. (2019) Metastatic vulvar Crohn’s disease preceding intestinal manifestations: a case report and short review. Acta Dermatovenerologica Alpina Pannonica et Adriatica 28:3.
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Cristiano Pagnini, Spyros I. Siakavellas & Giorgos Bamias. (2018) Systematic Review with Network Meta-Analysis: Efficacy of Induction Therapy with a Second Biological Agent in Anti-TNF-Experienced Crohn’s Disease Patients. Gastroenterology Research and Practice 2018, pages 1-9.
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Alay S Banker, Carlos Pavesio & Pauline Merrill. (2018) Emerging Treatments for Non-infectious Uveitis. US Ophthalmic Review 11:2, pages 81.
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