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Journal of Inflammation Research Volume 11, 2018 - Issue
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Original Research

Metformin ameliorated methotrexate-induced hepatorenal toxicity in rats in addition to its antitumor activity: two birds with one stone

Fatma H Rizk1 Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt
,
Amira A El Saadany2 Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt
,
Lamees Dawood3 Department of Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt
,
Heba H Elkaliny4 Department of histology, Faculty of Medicine, Tanta University, Tanta, Egypt
,
Naglaa I Sarhan4 Department of histology, Faculty of Medicine, Tanta University, Tanta, Egypt
,
Rehab Badawi5 Department of Tropical, Faculty of Medicine, Tanta University, Tanta, Egypt, [email protected]
&
Sherief Abd-Elsalam5 Department of Tropical, Faculty of Medicine, Tanta University, Tanta, Egypt, [email protected]Correspondence[email protected]
 show all
Pages 421-429 | Published online: 08 Nov 2018

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Meltem Özgöçmen, Halil Aşcı, Hatice Kübra Doğan, İlter İlhan, Şakir Pekgöz & Ali Mustafaoğlu. (2022) A study on Wistar Albino rats: investigating protective role of ramelteon on liver damage caused by methotrexate. Drug and Chemical Toxicology 45:6, pages 2678-2685.
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Articles from other publishers (11)

Kareman M. El-Beheiry, Magda El-Sayed El-Sayad, Thanaa A. El-Masry & Alaa E. Elsisi. (2023) Combination of metformin and hesperidin mitigates cyclophosphamide-induced hepatotoxicity. Emerging role of PPAR-γ/Nrf-2/NF-κB signaling pathway. International Immunopharmacology 117, pages 109891.
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Elif Tufan, Güzin Göksun Sivas, Begüm Gürel-Gökmen, Sümeyye Yılmaz-Karaoğlu, Ercan Dursun, Esin Çalışkan-Ak, Aleyna Muhan, Dilek Özbeyli, Göksel Şener & Tuğba Tunali-Akbay. (2023) Whey protein concentrate ameliorates the methotrexate-induced liver and kidney damage. British Journal of Nutrition, pages 1-8.
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Hoda A. Mahran, Yasser I. Khedr, Yasmeen M. Gawaan & Mohamed SA. El-Gerbed. (2022) Possible ameliorative effect of human placental extract on methotrexate-induced nephrotoxicity in albino rats. The Journal of Basic and Applied Zoology 83:1.
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Intesar Tarik Numan, Nadia Hameed Mohamed & Zainab Khalid Ali. (2022) Antioxidative effect of metformin on valproic acid induced hepatoxicity in male rats. Al Mustansiriyah Journal of Pharmaceutical Sciences 22:3, pages 17-23.
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Faten Al-Abkal, Basel A. Abdel-Wahab, Hanaa F. Abd El-Kareem, Yasser M. Moustafa & Dina M. Khodeer. (2022) Protective Effect of Pycnogenol against Methotrexate-Induced Hepatic, Renal, and Cardiac Toxicity: An In Vivo Study. Pharmaceuticals 15:6, pages 674.
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Huynh Thi Xuan Tam, Luong Nguyen Dac Thuy, Ngo Minh Vinh, Tran Ngoc Anh & Bui Thi Van. (2022) The Combined Use of Metformin and Methotrexate in Psoriasis Patients with Metabolic Syndrome. Dermatology Research and Practice 2022, pages 1-7.
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Ramkumar Katturajan, Vijayalakshmi S, Mahabookhan Rasool & Sabina Evan Prince. (2021) Molecular toxicity of methotrexate in rheumatoid arthritis treatment: A novel perspective and therapeutic implications. Toxicology 461, pages 152909.
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Sabry Ali El-Naggar, Mona Elwan, Mohamed Abo Elftouh Basyouny, Ehab Othman Elshennawy & Karim Samy El-Said. (2021) Metformin Causes Hepato-renal Dysfunctions in Obese Male Rats. Brazilian Archives of Biology and Technology 64.
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Catherine C. Ikewuchi, Jude C. Ikewuchi, Mercy O. Ifeanacho, Damiete P. Jack, Caleb N. Ikpe, Samuel Ehiosun & Tosin B. Ajayi. (2021) Protective effect of aqueous leaf extracts of Chromolaena odorata and Tridax procumbens on doxorubicin-induced hepatotoxicity in Wistar rats. Porto Biomedical Journal 6:6, pages e143.
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Catherine C. Ikewuchi, Mercy O. Ifeanacho & Jude C. Ikewuchi. (2021) Moderation of doxorubicin-induced nephrotoxicity in Wistar rats by aqueous leaf-extracts of Chromolaena odorata and Tridax procumbens. Porto Biomedical Journal 6:1, pages e129.
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Sherif, Al-Shaalan & Sabry. (2019) Ginkgo Biloba Extract Alleviates Methotrexate-Induced Renal Injury: New Impact on PI3K/Akt/mTOR Signaling and MALAT1 Expression. Biomolecules 9:11, pages 691.
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