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Original Research

Evaluation of the efficacy and safety of Capsule Longvida® Optimized Curcumin (solid lipid curcumin particles) in knee osteoarthritis: a pilot clinical study

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Pages 145-152 | Published online: 05 Jun 2019

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Ledyane Taynara Marton, Sandra Maria Barbalho, Kátia Portero Sloan, Lance Alan Sloan, Ricardo de Alvares Goulart, Adriano Cressoni Araújo & Marcelo Dib Bechara. (2022) Curcumin, autoimmune and inflammatory diseases: going beyond conventional therapy – a systematic review. Critical Reviews in Food Science and Nutrition 62:8, pages 2140-2157.
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Articles from other publishers (31)

Kirt R. Phipps, Victoria Bali, Dhaval Kukadia, Chintan Patel & Jayesh Muchhara. (2023) Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies. Journal of Applied Toxicology 43:6, pages 929-939.
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Ajaikumar B. Kunnumakkara, Mangala Hegde, Dey Parama, Sosmitha Girisa, Aviral Kumar, Uzini Devi Daimary, Prachi Garodia, Sarat Chandra Yenisetti, Oommen V. Oommen & Bharat B. Aggarwal. (2023) Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials. ACS Pharmacology & Translational Science 6:4, pages 447-518.
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Mohammad Jafar Dehzad, Hamid Ghalandari, Mehran Nouri & Moein Askarpour. (2023) Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose–response meta-analysis of randomized controlled trials. Cytokine 164, pages 156144.
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Mangala Hegde, Sosmitha Girisa, Bandari BharathwajChetty, Ravichandran Vishwa & Ajaikumar B. Kunnumakkara. (2023) Curcumin Formulations for Better Bioavailability: What We Learned from Clinical Trials Thus Far?. ACS Omega 8:12, pages 10713-10746.
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Timothy M. Panknin, Carol L. Howe, Meg Hauer, Bhanu Bucchireddigari, Anthony M. Rossi & Janet L. Funk. (2023) Curcumin Supplementation and Human Disease: A Scoping Review of Clinical Trials. International Journal of Molecular Sciences 24:5, pages 4476.
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Zhiqiang Wang, Tania Winzenberg, Ambrish Singh, Dawn Aitken, Leigh Blizzard, Mikael Boesen, Edwin H.G. Oei, Tijmen A. van Zadelhoff, Venkat Parameswaran, Changhai Ding, Robert Jones & Benny Antony. (2023) Effect of Curcuma longa extract on serum inflammatory markers and MRI-based synovitis in knee osteoarthritis: secondary analyses from the CurKOA randomised trial. Phytomedicine 109, pages 154616.
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F. M. Andrews, L. M. Riggs, M. J. Lopez, M. L. Keowen, F. GarzaJr.Jr., C. Takawira, C.‐C. Liu, Y. Liu, N. P. Seeram, A. Cairy & M. St. Blanc. (2022) Effect of an oral supplement containing curcumin extract (Longvida ® ) on lameness due to osteoarthritis and gastric ulcer scores . Equine Veterinary Education 34:12.
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Zhenqi Liu, Alison B. Lansley, Tu Ngoc Duong, John D. Smart & Ananth S. Pannala. (2022) Increasing Cellular Uptake and Permeation of Curcumin Using a Novel Polymer-Surfactant Formulation. Biomolecules 12:12, pages 1739.
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Jie Feng, Zhao Li, Linling Tian, Panyun Mu, Yimei Hu, Feng Xiong & Xu Ma. (2022) Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. BMC Complementary Medicine and Therapies 22:1.
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Rubiya Khursheed, Sachin Kumar Singh, Sheetu Wadhwa, Monica Gulati, Niraj Kumar Jha, Gaurav Gupta, Hari Prasad Devkota, Parteek Prasher, Dinesh Kumar Chellappan & Kamal Dua. (2022) A sojourn into therapeutic and nutraceutical potential of curcumin and its novel drug delivery system: Current achievements and future perspectives. South African Journal of Botany 149, pages 944-962.
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Chunlian Li, Weicheng Zhang, Xianyi Wu, Qiuyang Cai, Zekai Tan, Zhengyi Hong, Shiyuan Huang, Yanghe Yuan, Lewen Yao & Lanyue Zhang. (2022) Aromatic-turmerone ameliorates DSS-induced ulcerative colitis via modulating gut microbiota in mice. Inflammopharmacology 30:4, pages 1283-1294.
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Liuting Zeng, Tiejun Yang, Kailin Yang, Ganpeng Yu, Jun Li, Wang Xiang & Hua Chen. (2022) Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial. Frontiers in Immunology 13.
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Yingying Wan, Wenting Sun, Jiaxi Yang, Jianxun Ren & Qiuai Kou. (2022) The comparison of curcuminoid formulations or its combination with conventional therapies versus conventional therapies alone for knee osteoarthritis. Clinical Rheumatology 41:7, pages 2153-2169.
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Panyun Mu, Jie Feng, Yimei Hu, Feng Xiong, Xu Ma & Linling Tian. (2022) Botanical Drug Extracts Combined With Biomaterial Carriers for Osteoarthritis Cartilage Degeneration Treatment: A Review of 10 Years of Research. Frontiers in Pharmacology 12.
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Vidhu Sethi, Manohar Garg, Maxime Herve & Ali Mobasheri. (2022) Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis. Therapeutic Advances in Musculoskeletal Disease 14, pages 1759720X2211245.
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Bibi Marjan Razavi, Mahboobeh Ghasemzadeh Rahbardar & Hossein Hosseinzadeh. (2021) A review of therapeutic potentials of turmeric ( Curcuma longa ) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents . Phytotherapy Research 35:12, pages 6489-6513.
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Hui Xue, Baojun Wang, Tianyu Meng, Shijun Zhao, Qingyin Wang, Xin Zhang, Min Kang & Wenping Xiang. (2021) Differences of Sleep Disorders Between Vestibular Migraine and Benign Paroxysmal Positional Vertigo. Frontiers in Psychiatry 12.
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Wenli Dai, Wenqiang Yan, Xi Leng, Jing Chen, Xiaoqing Hu & Yingfang Ao. (2021) Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis: A systematic review and meta‐analysis of randomized controlled trials . Phytotherapy Research 35:11, pages 5921-5935.
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Brian K. McFarlin, David W. Hill, Jakob L. Vingren, John H. Curtis & Elizabeth A. Tanner. (2021) Dietary Polyphenol and Methylsulfonylmethane Supplementation Improves Immune, DAMP Signaling, and Inflammatory Responses During Recovery From All-Out Running Efforts. Frontiers in Physiology 12.
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Maryam Mahjoob & Ursula Stochaj. (2021) Curcumin nanoformulations to combat aging-related diseases. Ageing Research Reviews 69, pages 101364.
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Shaikh Jamal Uddin, Md. Fahim Hasan, Mohasana Afroz, Dipto Kumer Sarker, Razina Rouf, Muhammad Torequl Islam, Jamil A. Shilpi & Mohammad S. Mubarak. (2021) Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data. Current Drug Targets 22:6, pages 656-671.
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Shane M. Heffernan & Gillian E. Conway. 2021. Pain Management - Practices, Novel Therapies and Bioactives. Pain Management - Practices, Novel Therapies and Bioactives.
Jestin V. Thomas, Thozhuthum Parambil Smina, Aman Khanna, Ajaikumar B. Kunnumakkara, Balu Maliakel, Ratheesh Mohanan & Illathu Madhavamenon Krishnakumar. (2020) Influence of a low‐dose supplementation of curcumagalactomannoside complex ( CurQfen ) in knee osteoarthritis: A randomized, open‐labeled, active‐controlled clinical trial . Phytotherapy Research 35:3, pages 1443-1455.
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Maria-Luisa Pérez-Lozano, Annabelle Cesaro, Marija Mazor, Eric Esteve, Sabine Berteina-Raboin, Thomas M. Best, Eric Lespessailles & Hechmi Toumi. (2021) Emerging Natural-Product-Based Treatments for the Management of Osteoarthritis. Antioxidants 10:2, pages 265.
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Zhiqiang Wang, Ambrish Singh, Graeme Jones, Tania Winzenberg, Changhai Ding, Arvind Chopra, Siddharth Das, Debashish Danda, Laura Laslett & Benny Antony. (2021) Efficacy and Safety of Turmeric Extracts for the Treatment of Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomised Controlled Trials. Current Rheumatology Reports 23:2.
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Nafiseh Shokri-Mashhadi, Mohammad Bagherniya, Gholamreza Askari, Thozhukat Sathyapalan & Amirhossein Sahebkar. 2021. Studies on Biomarkers and New Targets in Aging Research in Iran. Studies on Biomarkers and New Targets in Aging Research in Iran 265 282 .
Mahdie Rahban, Mehran Habibi-Rezaei, Mansoureh Mazaheri, Luciano Saso & Ali A. Moosavi-Movahedi. (2020) Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications. Antioxidants 9:12, pages 1228.
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Bernd-Michael Löffler, Shintu Jude, Augustine Amalraj & Sreeraj Gopi. 2020. The Chemistry and Bioactive Components of Turmeric. The Chemistry and Bioactive Components of Turmeric 104 135 .
Mahdi. Atabaki, Zhaleh. Shariati-Sarabi, Jalil. Tavakkol-Afshari & Mojgan. Mohammadi. (2020) Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran. International Immunopharmacology 85, pages 106607.
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Jeffry Adiwidjaja, Alan V Boddy & Andrew J McLachlan. (2020) Physiologically-Based Pharmacokinetic Predictions of the Effect of Curcumin on Metabolism of Imatinib and Bosutinib: In Vitro and In Vivo Disconnect. Pharmaceutical Research 37:7.
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Erika Cione, Chiara La Torre, Roberto Cannataro, Maria Cristina Caroleo, Pierluigi Plastina & Luca Gallelli. (2019) Quercetin, Epigallocatechin Gallate, Curcumin, and Resveratrol: From Dietary Sources to Human MicroRNA Modulation. Molecules 25:1, pages 63.
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