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Journal of Inflammation Research Volume 12, 2019 - Issue
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Original Research

Linagliptin Inhibits Lipopolysaccharide-Induced Inflammation Concentration-Dependently And -Independently

Naoki Sato1 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan;2 Department of Research Center, Tanabe Pharmacy Inc., Tokyo, Japan
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Yuya Nakamura1 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan;3 Department of Nephrology, Saiyu Soka Hospital, Soka City, Saitama-ken, JapanORCID Iconhttps://orcid.org/0000-0002-6156-5975
ORCID Icon,
Shiho Yamadera4 Department of Hospital Pharmaceutics, Showa University School of Pharmacy, Shinagawa-ku, Tokyo, Japan
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Masahiro Inagaki1 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan;5 Fuculty of Arts and Sciences at Fujiyoshida, Showa University, Fujiyoshida City, Yamanashi-ken, Japan
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Sachiyo Kenmotsu5 Fuculty of Arts and Sciences at Fujiyoshida, Showa University, Fujiyoshida City, Yamanashi-ken, Japan
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Hiroshi Saito4 Department of Hospital Pharmaceutics, Showa University School of Pharmacy, Shinagawa-ku, Tokyo, Japan;6 Department of Healthcare and Regulatory Sciences, Showa University School of Pharmacy, Shinagawa-ku, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0002-5184-9181
ORCID Icon,
Tatsunori Oguchi1 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan
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Mayumi Tsuji1 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan
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Hirokazu Chokki1 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan
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Isao Ohsawa3 Department of Nephrology, Saiyu Soka Hospital, Soka City, Saitama-ken, Japan
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Hiromichi Gotoh3 Department of Nephrology, Saiyu Soka Hospital, Soka City, Saitama-ken, Japan
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Shinichi Iwai6 Department of Healthcare and Regulatory Sciences, Showa University School of Pharmacy, Shinagawa-ku, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0002-2726-0107
ORCID Icon &
Yuji Kiuchi1 Department of Pharmacology, Showa University School of Medicine, Shinagawa-ku, Tokyo, JapanORCID Iconhttps://orcid.org/0000-0001-7198-3735
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Pages 285-291 | Published online: 21 Oct 2019

Citations (8)

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Hiroshi Saito, Yuya Nakamura, Masahiro Inagaki, Shiho Yamadera, Hideo Misawa, Naoki Sato, Tatsunori Oguchi, Takae Inagaki, Yuya Tsuji, Mayumi Tsuji, Isao Ohsawa, Hiromichi Gotoh & Yuji Kiuchi. (2021) Linagliptin Inhibits Interleukin-6 Production Through Toll-Like Receptor 4 Complex and Lipopolysaccharide-Binding Protein Independent Pathway in vitro Model. Journal of Inflammation Research 14, pages 5681-5686.
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Articles from other publishers (7)

Snehasish Nag, Samanwita Mandal, Oindrila Mukherjee, Suprabhat Mukherjee & Rakesh Kundu. (2023) DPP-4 Inhibitors as a savior for COVID-19 patients with diabetes. Future Virology 18:5, pages 321-333.
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Panagiotis Theofilis, Marios Sagris, Evangelos Oikonomou, Alexios S. Antonopoulos, Gerasimos Siasos, Kostas Tsioufis & Dimitris Tousoulis. (2022) The Anti-Inflammatory Effect of Novel Antidiabetic Agents. Life 12:11, pages 1829.
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Na Zhang, Sihui Tang, Jinjin Zhang, Biwei Pei, Tingting Pang & Gengyun Sun. (2022) The dipeptidyl peptidase-4 inhibitor linagliptin ameliorates LPS-induced acute lung injury by maintenance of pulmonary microvascular barrier via activating the Epac1/AKT pathway. Biomedicine & Pharmacotherapy 155, pages 113704.
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Michał Konwerski, Aleksandra Gąsecka, Grzegorz Opolski, Marcin Grabowski & Tomasz Mazurek. (2022) Role of Epicardial Adipose Tissue in Cardiovascular Diseases: A Review. Biology 11:3, pages 355.
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Hideo Misawa, Yuya Nakamura, Masahiro Inagaki, Shiho Yamadera, Hiroshi Saito, Naoki SatoTakae Inagaki, Yuya Tsuji, Mayumi Tsuji, Sachiyo Kenmotsu, Isao Ohsawa, Hiromichi Gotoh & Yuji Kiuchi. (2022) Effects of ferric citrate on intracellular oxidative stress markers after hydrogen peroxide treatment of human U937 monocytes. The Showa University Journal of Medical Sciences 34:4, pages 215-220.
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Ahmed Elsanhoury, Vivian Nelki, Sebastian Kelle, Sophie Van Linthout & Carsten Tschöpe. (2021) Epicardial Fat Expansion in Diabetic and Obese Patients With Heart Failure and Preserved Ejection Fraction—A Specific HFpEF Phenotype. Frontiers in Cardiovascular Medicine 8.
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Niki Katsiki & Ele Ferrannini. (2020) Anti-inflammatory properties of antidiabetic drugs: A “promised land” in the COVID-19 era?. Journal of Diabetes and its Complications 34:12, pages 107723.
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