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Review

Identifying and meeting the challenges of insulin therapy in type 2 diabetes

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Pages 267-282 | Published online: 02 Jul 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Roopa Mehta, Ronald Goldenberg, Daniel Katselnik & Louis Kuritzky. (2021) Practical guidance on the initiation, titration, and switching of basal insulins: a narrative review for primary care. Annals of Medicine 53:1, pages 999-1010.
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Samaneh Kalirai, Jasmina I Ivanova, Magaly Perez-Nieves, Judith J Stephenson, Irene Hadjiyianni, Michael Grabner, Roy Daniel Pollom, Caroline Geremakis, Beverly L Reed & Lawrence Fisher. (2020) Basal Insulin Initiation and Maintenance in Adults with Type 2 Diabetes Mellitus in the United States. Diabetes, Metabolic Syndrome and Obesity 13, pages 1023-1033.
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Mark Peyrot, Timothy S. Bailey, Belinda P. Childs & Gérard Reach. (2018) Strategies for implementing effective mealtime insulin therapy in type 2 diabetes. Current Medical Research and Opinion 34:6, pages 1153-1162.
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Nella Bieszk, Michael Grabner, Wenhui Wei, Nicole G Bonine & Judith J Stephenson. (2016) The SWEET SPOTS study: a real-world interpretation of the 2012 American Diabetes Association Position Statement regarding individualized A1C targets. Risk Management and Healthcare Policy 9, pages 243-251.
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Dilek Gogas Yavuz, Habip Bilen, Seda Sancak, Tayfun Garip, Zeliha Hekimsoy, Ibrahim Sahin, Murat Yilmaz, Hasan Aydin, Aysegul Atmaca, Murat Sert, Pinar Karakaya, Dilek Arpaci, Aytekin Oguz & Nilgun Guvener. (2016) Impact of telephonic interviews on persistence and daily adherence to insulin treatment in insulin-naïve type 2 diabetes patients: dropout study. Patient Preference and Adherence 10, pages 851-861.
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Dilek Gogas Yavuz, Sevim Ozcan & Oguzhan Deyneli. (2015) Adherence to insulin treatment in insulin-naïve type 2 diabetic patients initiated on different insulin regimens. Patient Preference and Adherence 9, pages 1225-1231.
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Articles from other publishers (39)

Mireille A. Edens, Peter R. van Dijk, Eelko Hak & Henk J.G. Bilo. (2023) Determinants of excessive weight gain after the initiation of insulin therapy in type 2 diabetes mellitus: Retrospective inception cohort study (ZODIAC 60). Diabetes Research and Clinical Practice 200, pages 110719.
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Srikanth Bellary & Anthony H Barnett. (2023) Insulin icodec: evolution or revolution in diabetes therapy?. The Lancet Diabetes & Endocrinology.
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Juan Frias, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Kristen Syring, Paula Wullenweber, Axel Haupt & Christof Kazda. (2023) Safety and efficacy of once-weekly basal insulin Fc in people with type 2 diabetes previously treated with basal insulin: a multicentre, open-label, randomised, phase 2 study. The Lancet Diabetes & Endocrinology 11:3, pages 158-168.
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Anns Mahboob, Degiri Kalana Lasanga Senevirathne, Pradipta Paul, Faisal Nabi, Rizwan Hasan Khan & Ali Chaari. (2023) An investigation into the potential action of polyphenols against human Islet Amyloid Polypeptide aggregation in type 2 diabetes. International Journal of Biological Macromolecules 225, pages 318-350.
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Nour Ebrahim, Ksenia Shakirova & Erdem Dashinimaev. (2022) PDX1 is the cornerstone of pancreatic β-cell functions and identity. Frontiers in Molecular Biosciences 9.
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Diaa Al-Domi, Ayat Bozeya & Mohamed Al-Fandi. (2022) Development of an Insulin Nano-delivery System through Buccal Administration. Current Drug Delivery 19:8, pages 889-901.
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Xiaobo Liu, Yuxi Li, Li Guan, Xia He, Huiling Zhang, Jun Zhang, Juan Li, Dongling Zhong & Rongjiang Jin. (2022) A Systematic Review and Meta-Analysis of the Prevalence and Risk Factors of Depression in Type 2 Diabetes Patients in China. Frontiers in Medicine 9.
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Lutz Heinemann, Oliver Schnell, Bernhard Gehr, Nanette C. Schloot, Sven W. Görgens & Christoph Görgen. (2021) Digital Diabetes Management: A Literature Review of Smart Insulin Pens. Journal of Diabetes Science and Technology 16:3, pages 587-595.
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Nemanja Isajev, Vesna Bjegovic-Mikanovic, Zoran Bukumiric, David Vrhovac & Nebojsa M. Lalic. (2022) Predictors of Clinical Inertia and Type 2 Diabetes: Assessment of Primary Care Physicians and Their Patients. International Journal of Environmental Research and Public Health 19:8, pages 4436.
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Hagos Amare Gebreyesus, Girmatsion Fisseha Abreha, Sintayehu Degu Besherae, Merhawit Atsbha Abera, Abraha Hailu Weldegerima, Aregawi Haileslassie Gidey, Afework Mulugeta Bezabih, Tefera Belachew Lemma & Tsinuel Girma Nigatu. (2022) High atherogenic risk concomitant with elevated HbA1c among persons with type 2 diabetes mellitus in North Ethiopia. PLOS ONE 17:2, pages e0262610.
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Nurbanu Demirtürk & Erem Bilensoy. (2022) Nanocarriers targeting the diseases of the pancreas. European Journal of Pharmaceutics and Biopharmaceutics 170, pages 10-23.
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Karen McGuigan, Alyson Hill, Deirdre McCay, Maurice O’Kane & Vivien Coates. (2021) Overcoming Barriers to Injectable Therapies: Development of the ORBIT Intervention Within a Behavioural Change Framework. Frontiers in Clinical Diabetes and Healthcare 2.
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Jianmin Wu, Fritha Morrison, Zhenxiang Zhao, Ginger Haynes, Xuanyao He, Ayad K. Ali, Maria Shubina, Shervin Malmasi, Wendong Ge, Xiaomei Peng & Alexander Turchin. (2021) Reasons for discontinuing insulin and factors associated with insulin discontinuation in patients with type 2 diabetes mellitus: a real-world evidence study. Clinical Diabetes and Endocrinology 7:1.
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Jun Sung Moon, Sunghwan Suh, Sang Soo Kim, Heung Yong Jin, Jeong Mi Kim, Min Hee Jang, Kyung Ae Lee, Ju Hyung Lee, Seung Min Chung, Young Sang Lyu, Jin Hwa Kim, Sang Yong Kim, Jung Eun Jang, Tae Nyun Kim, Sung Woo Kim, Eonju Jeon, Nan Hee Cho, Mi-Kyung Kim, Hye Soon Kim, Il Seong Nam-Goong, Eun Sook Kim, Jin Ook Chung, Dong-Hyeok Cho, Chang Won Lee, Young Il Kim, Dong Jin Chung, Kyu Chang Won, In Joo Kim, Tae Sun Park, Duk Kyu Kim & Hosang Shon. (2021) Efficacy and Safety of Treatment with Quadruple Oral Hypoglycemic Agents in Uncontrolled Type 2 Diabetes Mellitus: A Multi-Center, Retrospective, Observational Study. Diabetes & Metabolism Journal 45:5, pages 675-683.
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Hailong Wan, Binhong Wen, Xueying Wang, Junfen Wang, Yunliang Zhang, Tao Ning, Binhong Duan, Yufang Li, Wei Feng, Xia Zhang, Nan Cui & Linong Ji. (2021) Effect of Baseline Characteristics on Hypoglycaemia Risk with Insulin Glargine 100 U/mL: Post Hoc Analysis of the BEYOND 7 Study. Diabetes Therapy 12:9, pages 2359-2369.
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Jaehyun Bae, Ji Hye Huh, Minyoung Lee, Yong‐Ho Lee & Byung‐Wan Lee. (2020) Glycaemic control with add‐on thiazolidinedione or a sodium‐glucose co‐transporter‐2 inhibitor in patients with type 2 diabetes after the failure of an oral triple antidiabetic regimen: A 24‐week, randomized controlled trial. Diabetes, Obesity and Metabolism 23:2, pages 609-618.
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Vidya Sundaram, Ramakrishnan Nagasundara Ramanan, Manikandan Selvaraj, R. Vijayaraghavan, Douglas R. MacFarlane & Chien Wei Ooi. (2021) Structural stability of insulin aspart in aqueous cholinium aminoate ionic liquids based on molecular dynamics simulation studies. Journal of Molecular Liquids 322, pages 114501.
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Trisha Zeidan, Carla Nikkel, Beth Dziengelewski, Stephanie Wu & Aleda M. H. Chen. (2020) Clinical Evaluation of Basal-Bolus Therapy Delivered by the V-Go® Wearable Insulin Delivery Device in Patients with Type 2 Diabetes: A Retrospective Analysis. Pharmacy 8:4, pages 215.
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Hamdiye Arda Sürücü, Gülbeyaz Baran Durmaz & Engin Turan. (2018) Does Type 1 Diabetic Adolescents’ Fear of Stigmatization Predict a Negative Perception Insulin Treatment?. Clinical Nursing Research 29:4, pages 235-242.
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Sanjay Kalra, Sarita Bajaj, Surendra Kumar Sharma, Gagan Priya, Manash P. Baruah, Debmalya Sanyal, Sambit Das, Tirthankar Chaudhury, Kalyan Kumar Gangopadhyay, Ashok Kumar Das, Bipin Sethi, Vageesh Ayyar, Shehla Shaikh, Parag Shah, Sushil Jindal, Vaishali Deshmukh, Joel Dave, Aslam Amod, Ansumali Joshi, Sunil Pokharel, Faruque Pathan, Faria Afsana, Indrajit Prasad, Moosa Murad, Soebagijo Adi Soelistijo, Johanes Purwoto, Zanariah Hussein, Lee Chung Horn, Rakesh Sahay, Noel Somasundaram, Charles Antonypillai, Manilka Sumanathilaka & Uditha Bulugahapitiya. (2020) A Practitioner’s Toolkit for Insulin Motivation in Adults with Type 1 and Type 2 Diabetes Mellitus: Evidence-Based Recommendations from an International Expert Panel. Diabetes Therapy 11:3, pages 585-606.
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Louis Kuritzky, Timothy S. Reid & Carol H. Wysham. (2019) Practical Guidance on Effective Basal Insulin Titration for Primary Care Providers. Clinical Diabetes 37:4, pages 368-376.
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Sarita Bajaj, A. K. Das, Sanjay Kalra, Rakesh Sahay, Banshi Saboo, Sambit Das, M. Shunmugavelu, Jubbin Jacob, Gagan Priya, Deepak Khandelwal, Deep Dutta, Manoj Chawla, Vineet Surana, Mangesh Tiwaskar, Ameya Joshi, Pradip Krishna Shrestha, Jyoti Bhattarai, Bishwajit Bhowmik, Tint Swe Latt, Than Than Aye, G. Vijayakumar, Manash Baruah, Fatema Jawad, A. G. Unnikrishnan, Subhankar Chowdhury, Md. Faruqe Pathan, Noel Somasundaram, Manilka Sumanathilaka, Abbas Raza, Silver K. Bahendeka, Ankia Coetzee, Sundeep Ruder, Kaushik Ramaiya, Roberta Lamptey, Charlotte Bavuma, Khalid Shaikh, Andrew Uloko, Sandeep Chaudhary, Abdurezak Ahmed Abdela, Zhanay Akanov, Joel Rodrìguez-Saldaña, Raquel Faradji, Armindo Tiago, Ahmed Reja & Leszek Czupryniak. (2019) BE-SMART (Basal Early Strategies to Maximize HbA1c Reduction with Oral Therapy): Expert Opinion. Diabetes Therapy 10:4, pages 1189-1204.
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Kai‐Jen Tien, Yi‐Jen Hung, Jung‐Fu Chen, Ching‐Chu Chen, Chih‐Yuan Wang, Chii‐Min Hwu, Yu‐Yao Huang, Pi‐Jung Hsiao, Shih‐Te Tu, Chao‐Hung Wang & Wayne Huey‐Herng Sheu. (2019) Basal insulin therapy: Unmet medical needs in Asia and the new insulin glargine in diabetes treatment. Journal of Diabetes Investigation 10:3, pages 560-570.
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Richard M. BergenstalMark PeyrotDarlene M. DreonVanita R. ArodaTimothy S. BaileyRonald L. BrazgJuan P. FriasMary L. JohnsonDavid C. KlonoffDavida F. KrugerShenaz RamtoolaJulio RosenstockPierre SerusclatRuth S. WeinstockRamachandra G. NaikDavid M. ShearerVivien ZraickBrian L. LevyThomas Behnke, Faramarz Beigi, Richard Bernstein, Anuj Bhargava, Hélène Bihan, Bruce Bode, Klaus Busch, Bertrand Cariou, Bogdan Catargi, Tira Chaicha-Brom, Sudesna Chatterjee, Belinda Childs, Sylvaine Clavel, Andrew Collier, Anne Farret, Leon Fogelfeld, Todd Gress, Markolf Hanefeld, Priscilla Hollander, David Huffman, Christopher Kelly, Mark Kipnes, See Kwok, Steven Leichter, Marc Lévy, Robert Lipetz, Rory McCrimmon, John McKnight, Mark Molitch, Derek Muse, Lyle Myers, Ola Odugbesan, Andreas Pfützner, Daniel Pomposini, Satyan Rajbhandari, Neda Rasouli, John Reed, Ernie Riffer, Jean-Pierre Riveline, Anthony Robinson, Peter Schwarz, Jörg Simon, William Simon, Ajay Sood, Larry Stonesifer, Charles Thivolet, Devjit Tripathy, Carl Vance, Michelle Welch, Alan Wynne & Reza Zaidi. (2019) Implementation of Basal–Bolus Therapy in Type 2 Diabetes: A Randomized Controlled Trial Comparing Bolus Insulin Delivery Using an Insulin Patch with an Insulin Pen. Diabetes Technology & Therapeutics 21:5, pages 273-285.
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Linong Ji, Zhengnan Gao, Bimin Shi, Rongwen Bian, Fuzai Yin, Wuyan Pang, Hong Gao & Nan Cui. (2018) Safety and Efficacy of High Versus Standard Starting Doses of Insulin Glargine in Overweight and Obese Chinese Individuals with Type 2 Diabetes Mellitus Inadequately Controlled on Oral Antidiabetic Medications (Beyond VII): Study Protocol for a Randomized Controlled Trial. Advances in Therapy 35:6, pages 864-874.
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Samaneh Kalirai, Judith Stephenson, Magaly Perez-Nieves, Michael Grabner, Irene Hadjiyianni, Caroline Geremakis, Roy Daniel Pollom, Beverly Reed & Lawrence Fisher. (2018) Primary care physician perspectives on basal insulin initiation and maintenance in patients with type 2 diabetes mellitus. Primary Care Diabetes 12:2, pages 155-162.
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Lori Berard, Noreen Antonishyn, Kathryn Arcudi, Sarah Blunden, Alice Cheng, Ronald Goldenberg, Stewart Harris, Shelley Jones, Upender Mehan, James Morrell, Robert Roscoe, Rick Siemens, Michael Vallis & Jean-François Yale. (2018) Insulin Matters: A Practical Approach to Basal Insulin Management in Type 2 Diabetes. Diabetes Therapy 9:2, pages 501-519.
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David Russell-Jones, Frans Pouwer & Kamlesh Khunti. (2018) Identification of barriers to insulin therapy and approaches to overcoming them. Diabetes, Obesity and Metabolism 20:3, pages 488-496.
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Mark Peyrot, Darlene Dreon, Vivien Zraick, Brett Cross & Meng H. Tan. (2018) Patient Perceptions and Preferences for a Mealtime Insulin Delivery Patch. Diabetes Therapy 9:1, pages 297-307.
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Mari Fløde, Marjolein M. Iversen, Morten Aarflot & Johannes Haltbakk. (2017) Lasting impact of an implemented self-management programme for people with type 2 diabetes referred from primary care: a one-group, before-after design. Scandinavian Journal of Caring Sciences 31:4, pages 789-795.
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Adrian Brown, Nicola Guess, Anne Dornhorst, Shahrad Taheri & Gary Frost. (2017) Insulin‐associated weight gain in obese type 2 diabetes mellitus patients: What can be done?. Diabetes, Obesity and Metabolism 19:12, pages 1655-1668.
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Yasuo Terauchi, Masahiro Tamura, Masayuki Senda, Ryoji Gunji & Kohei Kaku. (2017) Efficacy and safety of tofogliflozin in Japanese patients with type 2 diabetes mellitus with inadequate glycaemic control on insulin therapy (J-STEP/INS): Results of a 16-week randomized, double-blind, placebo-controlled multicentre trial. Diabetes, Obesity and Metabolism 19:10, pages 1397-1407.
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Bruce W. BodeFrancine R. KaufmanNan Vint. (2017) An Expert Opinion on Advanced Insulin Pump Use in Youth with Type 1 Diabetes. Diabetes Technology & Therapeutics 19:3, pages 145-154.
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Fabrício Tavares Mendonça, Marília Moreira Guimarães, Sérgio Honorato de Matos & Rúbia Garcia Dusi. (2017) Anesthetic management of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS/HIPEC): The importance of hydro-electrolytic and acid-basic control. International Journal of Surgery Case Reports 38, pages 1-4.
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Freddy Goldberg Eliaschewitz & Tânia Barreto. (2016) Concepts and clinical use of ultra-long basal insulin. Diabetology & Metabolic Syndrome 8:1.
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Su Yen Goh, Ernesto Ang, Shailendra Bajpai, Chaicharn Deerochanawong, Eun-Gyoung Hong, Zanariah Hussein, Shashank Joshi, Nor Azmi Kamaruddin, Sjoberg Kho, Alice Pik-Shan Kong, Chang Yu Pan, Riccardo Perfetti, Apichati Vichayanrat, Aleksandra Vlajnic & Juliana Chung-Ngor Chan. (2016) A patient-centric approach to optimise insulin therapy in Asia. Journal of Diabetes and its Complications 30:6, pages 973-980.
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Rosemarie Lajara, Jaime A. Davidson, Carla C. Nikkel & Tracy L. Morris. (2016) Clinical and Cost-Effectiveness of Insulin Delivery with V-GO® Disposable Insulin Delivery Device Versus Multiple Daily Injections in Patients with Type 2 Diabetes Inadequately Controlled on Basal Insulin. Endocrine Practice 22:6, pages 726-735.
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Usha Sambamoorthi, Arijita Deb, Steve Zhou, Rahul Garg, Tao Fan & Anders Boss. (2016) Rapid Acting Insulin Use and Persistence among Elderly Type 2 Diabetes Patients Adding RAI to Oral Antidiabetes Drug Regimens. Journal of Diabetes Research 2016, pages 1-12.
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Paweł Olczyk, Katarzyna Komosinska-Vassev, Paweł Ramos, Łukasz Mencner, Krystyna Olczyk & Barbara Pilawa. (2015) Interactions of short-acting, intermediate-acting and pre-mixed human insulins with free radicals—Comparative EPR examination. International Journal of Pharmaceutics 490:1-2, pages 9-15.
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