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Journal of Pain Research Volume 11, 2018 - Issue

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Original Research

Oral methylnaltrexone does not negatively impact analgesia in patients with opioid-induced constipation and chronic noncancer pain

Lynn R Webster1 PRA Health Sciences, Salt Lake City, UT, USA

Robert J Israel2 Clinical and Medical Affairs, Salix Pharmaceuticals, Bridgewater, NJ, USA, [email protected]Correspondence[email protected]

Pages 1503-1510 | Published online: 13 Aug 2018

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Citations (9)

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Articles from other publishers (9)

Flaminia Coluzzi, Maria Sole Scerpa, Monica Rocco & Diego Fornasari. (2022) The Impact of P-Glycoprotein on Opioid Analgesics: What’s the Real Meaning in Pain Management and Palliative Care?. International Journal of Molecular Sciences 23:22, pages 14125.
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D. Matthew Walentiny, Essie Komla, Léa T. Moisa, Mohammed A. Mustafa, Justin L. Poklis, Hamid I. Akbarali & Patrick M. Beardsley. (2021) Methylnaltrexone crosses the blood-brain barrier and attenuates centrally-mediated behavioral effects of morphine and oxycodone in mice. Neuropharmacology 185, pages 108437.
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Neel Mehta, Neal E. Slatkin, Robert J. Israel & Nancy Stambler. (2021) Attrition of methylnaltrexone treatment-emergent adverse events in patients with chronic noncancer pain and opioid-induced constipation: a post hoc pooled analysis of two clinical trials. F1000Research 10, pages 891.
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Richard J. Bodnar. (2020) Endogenous Opiates and Behavior: 2018. Peptides 132, pages 170348.
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Eugene R Viscusi & Andrew R Viscusi. (2020) Blood–brain barrier: mechanisms governing permeability and interaction with peripherally acting μ-opioid receptor antagonists. Regional Anesthesia & Pain Medicine 45:9, pages 688-695.
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Charles E. Argoff. (2020) Opioid-induced Constipation. The Clinical Journal of Pain 36:9, pages 716-722.
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Priya Vijayvargiya, Michael Camilleri, Pooja Vijayvargiya, Patricia Erwin & M. Hassan Murad. (2020) Systematic review with meta-analysis: efficacy and safety of treatments for opioid-induced constipation. Alimentary Pharmacology & Therapeutics 52:1, pages 37-53.
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Daniel D. Long, Scott R. Armstrong, David T. Beattie, Christina B. Campbell, Timothy J. Church, Pierre-Jean Colson, Sean M. Dalziel, John R. Jacobsen, Lan Jiang, Glenmar P. Obedencio, Miroslav Rapta, Daisuke Saito, Ioanna Stergiades, Pamela R. Tsuruda, Priscilla M. Van Dyke & Ross G. Vickery. (2019) Discovery of Axelopran (TD-1211): A Peripherally Restricted μ-Opioid Receptor Antagonist. ACS Medicinal Chemistry Letters 10:12, pages 1641-1647.
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Miriam Martínez-Navarro, Rafael Maldonado & Josep-E. Baños. (2019) Why mu-opioid agonists have less analgesic efficacy in neuropathic pain?. European Journal of Pain 23:3, pages 435-454.
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