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Review

Co-crystals as a new approach to multimodal analgesia and the treatment of pain

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Pages 2679-2689 | Published online: 04 Sep 2019

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Prabhakar S. Panzade & Giridhar R. Shendarkar. (2020) Pharmaceutical cocrystal: a game changing approach for the administration of old drugs in new crystalline form. Drug Development and Industrial Pharmacy 46:10, pages 1559-1568.
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Rupesh A. Saindane & Nilima A. Thombre. (2023) Drug–Drug Cocrystals: A Promising Approach to Overcome Barriers in Pain Management. Crystal Research and Technology 58:7.
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Eman A. Bahgat, Hisham Hashem, Hanaa Saleh, Ebraam B. Kamel & Maya S. Eissa. (2023) Green micelle and complex inclusion enhance synchronous spectrofluorimetric quantification of a novel analgesic combination: Tramadol and celecoxib in tablet dosage form and spiked human plasma. Luminescence 38:4, pages 389-400.
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Eugene R. Viscusi, Oscar de Leon‐Casasola, Jesús Cebrecos, Adam Jacobs, Adelaida Morte, Esther Ortiz, Mariano Sust, Anna Vaqué, Ira Gottlieb, Stephen Daniels, Joseph S. Gimbel, Derek Muse, Peter Winkle, Michael E. Kuss, Sebastián Videla, Neus Gascón & Carlos Plata‐Salamán. (2022) Celecoxib‐tramadol co‐crystal in patients with moderate‐to‐severe pain following bunionectomy with osteotomy: A phase 3, randomized, double‐blind, factorial, active‐ and placebo‐controlled trial. Pain Practice 23:1, pages 8-22.
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Alba Vidal-Torres, Begoña Fernández-Pastor, Mónica García, Eva Ayet, Anna Cabot, Javier Burgueño, Xavier Monroy, Bertrand Aubel, Xavier Codony, Luz Romero, Rosalía Pascual, Maria Teresa Serafini, Gregorio Encina, Carmen Almansa, Daniel Zamanillo, Manuel Merlos & José Miguel Vela. (2023) Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and safety profile compared to strong opioids. Acta Pharmaceutica Sinica B 13:1, pages 82-99.
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Amin Alvani & Ali Shayanfar. (2022) Solution Stability of Pharmaceutical Cocrystals. Crystal Growth & Design 22:10, pages 6323-6337.
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Madhulika Banerjee, Kartik Nimkar, Shivraj Naik & Vandana Patravale. (2022) Unlocking the potential of drug-drug cocrystals – A comprehensive review. Journal of Controlled Release 348, pages 456-469.
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Prabhakar S. Panzade, Giridhar R. Shendarkar & Deepak A. Kulkarni. (2020) Hot Melt Extrusion: an Emerging Green Technique for the Synthesis of High-Quality Pharmaceutical Cocrystals. Journal of Pharmaceutical Innovation 17:2, pages 283-293.
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Zhengge Yang, Ru Ma, Yin Chen, Yifang Zhang, Xin Liu, Bi-Feng Liu, Guisen Zhang & Chao Hao. (2022) Drug-drug eutectic mixtures of celecoxib with tapentadol and milnacipran which could improve analgesic and antidepressant efficacy. Journal of Drug Delivery Science and Technology 67, pages 102995.
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Inês O. Feliciano, Daniela P. Silva, M. Fátima M. Piedade, Carlos E. S. Bernardes & Manuel E. Minas da Piedade. (2021) First and Second Dissociation Enthalpies in Bi-Component Crystals Consisting of Maleic Acid and L-Phenylalanine. Molecules 26:18, pages 5714.
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Barbara Stella, Francesca Baratta, Carlo Della Pepa, Silvia Arpicco, Daniela Gastaldi & Franco Dosio. (2021) Cannabinoid Formulations and Delivery Systems: Current and Future Options to Treat Pain. Drugs 81:13, pages 1513-1557.
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Ilma Nugrahani & Rismaya Desti Parwati. (2021) Challenges and Progress in Nonsteroidal Anti-Inflammatory Drugs Co-Crystal Development. Molecules 26:14, pages 4185.
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Jesús Cebrecos, James D. Carlson, Gregorio Encina, Mounia Lahjou, Artur Sans, Mariano Sust, Anna Vaqué, Adelaida Morte, Neus Gascón & Carlos Plata-Salamán. (2021) Celecoxib-tramadol co-crystal: A Randomized 4-Way Crossover Comparative Bioavailability Study. Clinical Therapeutics 43:6, pages 1051-1065.
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Prabhakar Panzade, Giridhar ShendarkarDeepak Kulkarni & Santosh Shelke. (2020) Solid State Characterization and Dissolution Enhancement of Nevirapine Cocrystals. Advanced Pharmaceutical Bulletin 11:4, pages 772-776.
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Patrycja Garbacz, Dominik Paukszta, Artur Sikorski & Marek Wesolowski. (2020) Structural Characterization of Co-Crystals of Chlordiazepoxide with p-Aminobenzoic Acid and Lorazepam with Nicotinamide by DSC, X-ray Diffraction, FTIR and Raman Spectroscopy. Pharmaceutics 12:7, pages 648.
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