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Journal of Pain Research Volume 13, 2020 - Issue

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Original Research

Dual-Acting Peripherally Restricted Delta/Kappa Opioid (CAV1001) Produces Antinociception in Animal Models of Sub-Acute and Chronic Pain

Craig T Hartrick1 Caventure Drug Discovery, Bloomfield Hills, MI, USACorrespondence[email protected]

Dominic Poulin2 Charles River Laboratories, Montreal, Canada

Rebekka Molenaar3 American Preclinical Services, Minneapolis, MN, USA

Allison Hartrick1 Caventure Drug Discovery, Bloomfield Hills, MI, USA

Pages 2461-2474 | Published online: 06 Oct 2020

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Mengchu Li, David L. Stevens, Michelle Arriaga, E. Andrew Townsend, Rolando E. Mendez, Nadejda A. Blajkevch, Dana E. Selley, Matthew L. Banks, S. Stevens Negus, William L. Dewey & Yan Zhang. (2022) Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure–Activity Relationship Study on Nalfurafine Analogues. ACS Chemical Neuroscience 13:24, pages 3608-3628.
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Richard J. Bodnar. (2022) Endogenous opiates and behavior: 2020. Peptides 151, pages 170752.
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Craig T. Hartrick. (2022) Exploiting Injury-Induced Peripheral Opioid Receptor Changes in Novel Analgesic Development for Chronic Pain. Frontiers in Pain Research 3.
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Yuka Uenohara, Saori Tsumura, Shigeto Hirayama, Eika Higashi, Yurie Watanabe, Hiroaki Gouda, Hiroshi Nagase & Hideaki Fujii. (2022) Morphinan derivatives with an oxabicyclo[3.2.1]octane structure as dual agonists toward δ and κ opioid receptors. Bioorganic & Medicinal Chemistry 53, pages 116552.
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Jin Hee Lee, Suh-Youn Shon, Woojin Jeon, Sung-Jun Hong, Junsu Ban & Do Sup Lee. (2021) Discovery of μ,δ-Opioid Receptor Dual-Biased Agonists That Overcome the Limitation of Prior Biased Agonists. ACS Pharmacology & Translational Science 4:3, pages 1149-1160.
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