Advanced search
Publication Cover
Journal of Pain Research Volume 5, 2012 - Issue
Submit an article Journal homepage
585
Views
56
CrossRef citations to date
0
Altmetric
Case Series

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

Jan M Keppel HesselinkInstitute for Neuropathic Pain, Bosch en Duin, NetherlandsCorrespondence[email protected]
&
Thecla AM HekkerInstitute for Neuropathic Pain, Bosch en Duin, Netherlands
Pages 437-442 | Published online: 26 Oct 2012

Citations (56)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Zeynab Alshelh, Emily P Mills, Danny Kosanovic, Flavia Di Pietro, Paul M Macey, E Russell Vickers & Luke A Henderson. (2019) Effects of the glial modulator palmitoylethanolamide on chronic pain intensity and brain function. Journal of Pain Research 12, pages 2427-2439.
Read now
Jan M Keppel Hesselink. (2013) Evolution in pharmacologic thinking around the natural analgesic palmitoylethanolamide: from nonspecific resistance to PPAR-α agonist and effective nutraceutical. Journal of Pain Research 6, pages 625-634.
Read now
Jan M Keppel Hesselink & David J Kopsky. (2013) Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells. Journal of Pain Research 6, pages 239-245.
Read now
J M Keppel Hesselink. (2013) Chronic idiopathic axonal neuropathy and pain, treated with the endogenous lipid mediator palmitoylethanolamide: a case collection. International Medical Case Reports Journal 6, pages 49-53.
Read now

Articles from other publishers (52)

Alessandro Tafuri, Andrea Panunzio, Rita De Mitri, Federico Benetti, Elisa Gaio & Vincenzo Pagliarulo. (2023) Micronized Palmitoylethanolamide, Hempseed Oil, and Maritime Pine Bark Dry Extract (Pelvipea®) for Pelvic Pain: An In Vitro Study for Urothelial Inflammation Treatment. Cells 12:4, pages 616.
Crossref
Matteo Bonetti, Dorina Lauritano, Gian Maria Ottaviani, Alessandro Fontana, Michele Frigerio, Alessio Zambello, Luigi Della Gatta, Mario Muto & Francesco Carinci. (2022) New Approach to Chronic Back Pain Treatment: A Case Control Study. Biomedicines 11:1, pages 73.
Crossref
Damiana Scuteri, Francesca Guida, Serena Boccella, Enza Palazzo, Sabatino Maione, Juan Francisco Rodríguez-Landa, Lucia Martínez-Mota, Paolo Tonin, Giacinto Bagetta & Maria Tiziana Corasaniti. (2022) Effects of Palmitoylethanolamide (PEA) on Nociceptive, Musculoskeletal and Neuropathic Pain: Systematic Review and Meta-Analysis of Clinical Evidence. Pharmaceutics 14:8, pages 1672.
Crossref
Pierangelo Cifelli, Gabriele Ruffolo, Marco Ceccanti, Chiara Cambieri, Laura Libonati, Eleonora Palma & Maurizio Inghilleri. (2022) Classical and Unexpected Effects of Ultra-Micronized PEA in Neuromuscular Function. Biomolecules 12:6, pages 758.
Crossref
Amanda Rao, Phillippa Ebelt, Alistair Mallard & David Briskey. (2021) Palmitoylethanolamide for sleep disturbance. A double-blind, randomised, placebo-controlled interventional study. Sleep Science and Practice 5:1.
Crossref
Jae In Jung, Hyun Sook Lee, Young Eun Jeon, So Mi Kim, Su Hee Hong, Joo Myung Moon, Cho Young Lim, Yoon Hee Kim & Eun Ji Kim. (2021) Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague–Dawley rats. Inflammopharmacology 29:5, pages 1475-1486.
Crossref
Jessica C. Gaspar, Catherine Healy, Mehnaz I. Ferdousi, Michelle Roche & David P. Finn. (2021) Pharmacological Blockade of PPARα Exacerbates Inflammatory Pain-Related Impairment of Spatial Memory in Rats. Biomedicines 9:6, pages 610.
Crossref
Michela Campolo, Marika Lanza, Irene Paterniti, Alessia Filippone, Alessio Ardizzone, Giovanna Casili, Sarah A. Scuderi, Caterina Puglisi, Marzia Mare, Lorenzo Memeo, Salvatore Cuzzocrea & Emanuela Esposito. (2021) PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis. International Journal of Molecular Sciences 22:8, pages 3927.
Crossref
Julie Wendt, Colleen Considine & Mikhail KoganJulie Wendt, Colleen Considine & Mikhail Kogan. 2021. Integrative Geriatric Nutrition. Integrative Geriatric Nutrition 59 87 .
Xianjin Du, Miao Wu, Dan Tian, Jianlin Zhou, Lu Wang & Liying Zhan. (2020) MicroRNA-21 Contributes to Acute Liver Injury in LPS-Induced Sepsis Mice by Inhibiting PPARα Expression. PPAR Research 2020, pages 1-7.
Crossref
Maria Cristina Caroleo, Antonella Brizzi, Maria De Rosa, Ankur Pandey, Luca Gallelli, Mariateresa Badolato, Gabriele Carullo & Erika Cione. (2020) Targeting Neuropathic Pain: Pathobiology, Current Treatment and Peptidomimetics as a New Therapeutic Opportunity. Current Medicinal Chemistry 27:9, pages 1469-1500.
Crossref
Marika Cordaro, Salvatore Cuzzocrea & Rosalia Crupi. (2020) An Update of Palmitoylethanolamide and Luteolin Effects in Preclinical and Clinical Studies of Neuroinflammatory Events. Antioxidants 9:3, pages 216.
Crossref
Esmaeal Tamaddonfard, Amir Erfanparast, Reza Salighedar & Sina Tamaddonfard. (2019) Medial prefrontal cortex diclofenac-induced antinociception is mediated through GPR55, cannabinoid CB1, and mu-opioid receptors of this area and periaqueductal gray. Naunyn-Schmiedeberg's Archives of Pharmacology 393:3, pages 371-379.
Crossref
Kolter B Grigsby, Antonia M Savarese, Pamela Metten, Barbara J Mason, Yuri A Blednov, John C Crabbe & Angela R Ozburn. (2020) Effects of Tacrolimus and Other Immune Targeting Compounds on Binge-Like Ethanol Drinking in High Drinking in the Dark Mice. Neuroscience Insights 15, pages 263310552097541.
Crossref
Bruno A. Marichal-Cancino, Abimael González-Hernández, Antoinette MaassenVanDenBrink, Eduardo Ramírez-San Juan & Carlos M. Villalón. (2020) Potential Mechanisms Involved in Palmitoylethanolamide-Induced Vasodepressor Effects in Rats. Journal of Vascular Research 57:3, pages 152-163.
Crossref
Sandra Cecconi, Cinzia Rapino, Valentina Di Nisio, Gianna Rossi & Mauro Maccarrone. (2020) The (endo)cannabinoid signaling in female reproduction: What are the latest advances?. Progress in Lipid Research 77, pages 101019.
Crossref
Mellar P. Davis, Bertrand Behm, Zankhana Mehta & Carlos Fernandez. (2019) The Potential Benefits of Palmitoylethanolamide in Palliation: A Qualitative Systematic Review. American Journal of Hospice and Palliative Medicine® 36:12, pages 1134-1154.
Crossref
Yannick Fotio, Amina Aboufares El Alaoui, Anna Maria Borruto, Samantha Acciarini, Antonio Giordano & Roberto Ciccocioppo. (2019) Efficacy of a Combination of N-Palmitoylethanolamide, Beta-Caryophyllene, Carnosic Acid, and Myrrh Extract on Chronic Neuropathic Pain: A Preclinical Study. Frontiers in Pharmacology 10.
Crossref
Elizabeth Steels, Ruchitha Venkatesh, Eleanor Steels, Gemma Vitetta & Luis Vitetta. (2019) A double-blind randomized placebo controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis. Inflammopharmacology 27:3, pages 475-485.
Crossref
Bright N Okine, Jessica C Gaspar & David P Finn. (2019) PPARs and pain. British Journal of Pharmacology 176:10, pages 1421-1442.
Crossref
Sara A. Aldossary, Mohammad Alsalem, Heba Kalbouneh, Mansour Haddad, Belal Azab, Othman Al-shboul, Ayman G. Mustafa, Sarah Obiedat & Khalid El-Salem. (2019) The role of transient receptor potential vanilloid receptor 1 and peroxisome proliferator-activated receptors-α in mediating the antinociceptive effects of palmitoylethanolamine in rats. NeuroReport 30:1, pages 32-37.
Crossref
Nicole L. Stone, Sophie A. Millar, Philip J. J. Herrod, David A. Barrett, Catharine A. Ortori, Valerie A. Mellon & Saoirse E. O’Sullivan. (2018) An Analysis of Endocannabinoid Concentrations and Mood Following Singing and Exercise in Healthy Volunteers. Frontiers in Behavioral Neuroscience 12.
Crossref
Mona Khalaj, Amene Saghazadeh, Elham Shirazi, Mohammad-Reza Shalbafan, Kaveh Alavi, Mitera Hakim Shooshtari, Fatemeh Yousefi Laksari, Maryamalsadat Hosseini, Mohammad-Reza Mohammadi & Shahin Akhondzadeh. (2018) Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial. Journal of Psychiatric Research 103, pages 104-111.
Crossref
Jan M. Keppel Hesselink. (2017) Fundamentals of and Critical Issues in Lipid Autacoid Medicine: A Review. Pain and Therapy 6:2, pages 153-164.
Crossref
Jordi Faig-Martí & Adriana Martínez-Catassús. (2017) Use of palmitoylethanolamide in carpal tunnel syndrome: a prospective randomized study. Journal of Orthopaedics and Traumatology 18:4, pages 451-455.
Crossref
Rocco Salvatore Calabrò & Placido Bramanti. (2017) Occipital Neuralgia Responding to Palmitoylethanolamide. Headache: The Journal of Head and Face Pain 57:10, pages E23-E24.
Crossref
Jie Ren, Yuhang Li, Hongwei Ke, Yanting Li, Longhe Yang, Helin Yu, Rui Huang, Canzhong Lu & Yan Qiu. (2017) Design, synthesis, and biological evaluation of oxazolidone derivatives as highly potent N-acylethanolamine acid amidase (NAAA) inhibitors. RSC Advances 7:21, pages 12455-12463.
Crossref
J.M. Keppel Hesselink. 2017. Nutrition and Lifestyle in Neurological Autoimmune Diseases. Nutrition and Lifestyle in Neurological Autoimmune Diseases 29 37 .
Stephen D. Skaper. 2017. Endocannabinoids and Lipid Mediators in Brain Functions. Endocannabinoids and Lipid Mediators in Brain Functions 347 369 .
Zahir Hussain, Toru Uyama, Katsuhisa Kawai, Iffat Ara Sonia Rahman, Kazuhito Tsuboi, Nobukazu Araki & Natsuo Ueda. (2016) Comparative analyses of isoforms of the calcium-independent phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and mice. Journal of Lipid Research 57:11, pages 2051-2060.
Crossref
Nicola S. Orefice, Mireille Alhouayek, Antonio Carotenuto, Silvana Montella, Franscesco Barbato, Albert Comelli, Antonio Calignano, Giulio G. Muccioli & Giuseppe Orefice. (2016) Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing–Remitting Multiple Sclerosis. Neurotherapeutics 13:2, pages 428-438.
Crossref
Richard Gowan & Isabelle Iff. 2016. Feline Behavioral Health and Welfare. Feline Behavioral Health and Welfare 184 212 .
Edoardo Tartaglia, Mario Armentano, Brunella Giugliano, Teresa Sena, Piero Giuliano, Castrese Loffredo & Pasquale Mastrantonio. (2015) Effectiveness of the Association N-Palmitoylethanolamine and Transpolydatin in the Treatment of Primary Dysmenorrhea. Journal of Pediatric and Adolescent Gynecology 28:6, pages 447-450.
Crossref
Louis J. Cohen, Hahk-Soo KangJohn ChuYun-Han HuangEmma A. GordonBoojala Vijay B. ReddyMelinda A. TerneiJeffrey W. CraigSean F. Brady. (2015) Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proceedings of the National Academy of Sciences 112:35.
Crossref
Dieter Pöhlau, Martin Raithel, Britta Haenisch, Sabrina Harzer & Gerhard J. Molderings. (2015) Neurologische und psychiatrische Symptome der systemischen MCAD. NeuroTransmitter 26:9, pages 46-50.
Crossref
Myrna Déciga-Campos & Rolffy Ortíz-Andrade. (2015) Enhancement of Antihyperalgesia by the Coadministration of N-palmitoylethanolamide and Acetaminophen in Diabetic Rats. Drug Development Research 76:5, pages 228-234.
Crossref
Lorenzo Di Cesare Mannelli, Alessandra Pacini, Francesca Corti, Serena Boccella, Livio Luongo, Emanuela Esposito, Salvatore Cuzzocrea, Sabatino Maione, Antonio Calignano & Carla Ghelardini. (2015) Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity. PLOS ONE 10:6, pages e0128080.
Crossref
Robert Rountree. (2015) Roundoc Rx: Nutritional and Botanical Approaches for Peripheral Neuropathy. Alternative and Complementary Therapies 21:3, pages 99-105.
Crossref
Marco Castori, Silvia Morlino, Giulia Pascolini, Carlo Blundo & Paola Grammatico. (2015) Gastrointestinal and nutritional issues in joint hypermobility syndrome/ehlers-danlos syndrome, hypermobility type. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 169:1, pages 54-75.
Crossref
Marco Castori, Michela Bruschini & Carlo Blundo. 2015. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease. Bioactive Nutraceuticals and Dietary Supplements in Neurological and Brain Disease 161 170 .
Stefano Ponzano, Anna Berteotti, Rita Petracca, Romina Vitale, Luisa Mengatto, Tiziano Bandiera, Andrea Cavalli, Daniele Piomelli, Fabio Bertozzi & Giovanni Bottegoni. (2014) Synthesis, Biological Evaluation, and 3D QSAR Study of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters as N -Acylethanolamine Acid Amidase (NAAA) Inhibitors . Journal of Medicinal Chemistry 57:23, pages 10101-10111.
Crossref
Filomena Fezza, Monica Bari, Rita Florio, Emanuela Talamonti, Monica Feole & Mauro Maccarrone. (2014) Endocannabinoids, Related Compounds and Their Metabolic Routes. Molecules 19:11, pages 17078-17106.
Crossref
Elvira Luongo, Roberto Russo, Carmen Avagliano, Anna Santoro, Daniela Melisi, Nicola Salvatore Orefice, Giuseppina Mattace Raso, Rosaria Meli, Salvatore Magliocca, Maria Nieddu, Gilvandete Maria Pinheiro Santiago, Gianpiero Boatto, Antonio Calignano & Maria Grazia Rimoli. (2014) Galactosyl prodrug of palmitoylethanolamide: Synthesis, stability, cell permeation and cytoprotective activity. European Journal of Pharmaceutical Sciences 62, pages 33-39.
Crossref
Ciro CostagliolaMario R. RomanoRoberto dell'OmoAndrea RussoRodolfo MastropasquaFrancesco Semeraro. (2014) Effect of Palmitoylethanolamide on Visual Field Damage Progression in Normal Tension Glaucoma Patients: Results of an Open-Label Six-Month Follow-Up. Journal of Medicinal Food 17:9, pages 949-954.
Crossref
Caroline M. Freitag & Richard J. Miller. (2014) Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines?. Frontiers in Cellular Neuroscience 8.
Crossref
Declan P McKernan & David P Finn. (2014) An apPEAling new therapeutic for ulcerative colitis?. Gut 63:8, pages 1207-1208.
Crossref
Tiziano Bandiera, Stefano Ponzano & Daniele Piomelli. (2014) Advances in the discovery of N-acylethanolamine acid amidase inhibitors. Pharmacological Research 86, pages 11-17.
Crossref
Jan M. Keppel Hesselink, David J. Kopsky & Nancy L. Sajben. (2014) Vulvodynia and proctodynia treated with topical baclofen 5 % and palmitoylethanolamide. Archives of Gynecology and Obstetrics 290:2, pages 389-393.
Crossref
Annalisa Fiasella, Andrea Nuzzi, Maria Summa, Andrea Armirotti, Glauco Tarozzo, Giorgio Tarzia, Marco Mor, Fabio Bertozzi, Tiziano Bandiera & Daniele Piomelli. (2014) 3-Aminoazetidin-2-one Derivatives as N -Acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration . ChemMedChem 9:7, pages 1602-1614.
Crossref
Romina Vitale, Giuliana Ottonello, Rita Petracca, Sine Mandrup Bertozzi, Stefano Ponzano, Andrea Armirotti, Anna Berteotti, Mauro Dionisi, Andrea Cavalli, Daniele Piomelli, Tiziano Bandiera & Fabio Bertozzi. (2014) Synthesis, Structure-Activity, and Structure-Stability Relationships of 2-Substituted- N -(4-oxo-3-oxetanyl) N -Acylethanolamine Acid Amidase (NAAA) Inhibitors . ChemMedChem 9:2, pages 323-336.
Crossref
Stephen D. Skaper, Laura Facci & Pietro Giusti. (2013) Glia and Mast Cells as Targets for Palmitoylethanolamide, an Anti-inflammatory and Neuroprotective Lipid Mediator. Molecular Neurobiology 48:2, pages 340-352.
Crossref
Stefano Ponzano, Fabio Bertozzi, Luisa Mengatto, Mauro Dionisi, Andrea Armirotti, Elisa Romeo, Anna Berteotti, Claudio Fiorelli, Glauco Tarozzo, Angelo Reggiani, Andrea Duranti, Giorgio Tarzia, Marco Mor, Andrea Cavalli, Daniele Piomelli & Tiziano Bandiera. (2013) Synthesis and Structure–Activity Relationship (SAR) of 2-Methyl-4-oxo-3-oxetanylcarbamic Acid Esters, a Class of Potent N -Acylethanolamine Acid Amidase (NAAA) Inhibitors . Journal of Medicinal Chemistry 56:17, pages 6917-6934.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.