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Review

NGF – the TrkA to successful pain treatment

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Pages 279-287 | Published online: 17 Aug 2012

Keep up to date with the latest research on this topic with citation updates for this article.

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Sabrina Bimonte, Marco Cascella, Cira Antonietta Forte, Gennaro Esposito & Arturo Cuomo. (2021) The Role of Anti-Nerve Growth Factor Monoclonal Antibodies in the Control of Chronic Cancer and Non-Cancer Pain. Journal of Pain Research 14, pages 1959-1967.
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Kinga Sałat, Paula Kowalczyk, Beata Gryzło, Anna Jakubowska & Katarzyna Kulig. (2014) New investigational drugs for the treatment of neuropathic pain. Expert Opinion on Investigational Drugs 23:8, pages 1093-1104.
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Articles from other publishers (50)

Doudou Jing, Qian Zhao, Yibo Zhao, Xiangdong Lu, Yi Feng, Bin Zhao & Xiaofeng Zhao. (2023) Management of pain in patients with bone metastases. Frontiers in Oncology 13.
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Beatriz C. Moraes, Helder V. Ribeiro-Filho, Allan P. Roldão, Elaine F. Toniolo, Gustavo P. B. Carretero, Germán G. Sgro, Fernanda A. H. Batista, Damian E. Berardi, Victoria R. S. Oliveira, Rebeka TomasinFelipe M. Vieceli, Dimitrius T. Pramio, Alexandre B. Cardoso, Ana C. M. Figueira, Shaker C. Farah, Lakshmi A. Devi, Camila S. Dale, Paulo S. L. de Oliveira & Deborah Schechtman. (2022) Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLCγ as an analgesic drug target. Science Signaling 15:731.
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Shuang Liu, Yunlong Shen, Pengyu Chen, Cuiyu Guo, Guangbing Zhang, Xiaohua Jiang, Jianxiong He & Jinliang Yang. (2022) Preparation and characterization of a high-affinity monoclonal antibody against nerve growth factor. Protein Expression and Purification 189, pages 105966.
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Carlos de Teresa, Alfonso Varela-López, Susana Rios-Álvarez, Rafael Gálvez, Coralie Maire, Santos Gracia-Villar, Maurizio Battino & José L. Quiles. (2021) Evaluation of the Analgesic Efficacy of a Bioelectronic Device in Non-Specific Chronic Low Back Pain with Neuropathic Component. A Randomized Trial. Journal of Clinical Medicine 10:8, pages 1781.
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Yuan Tian, Tomohiro Onodera, Mohamad Alaa Terkawi, Koji Iwasaki, Ryosuke Hishimura, Dawei Liang, Takuji Miyazaki & Norimasa Iwasaki. (2021) Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model. International Journal of Molecular Sciences 22:5, pages 2552.
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Thimios A. Mitsiadis & Pierfrancesco Pagella. 2021. Recent Advances in NGF and Related Molecules. Recent Advances in NGF and Related Molecules 65 75 .
James S. Dunn, Saad S. Nagi & David A. Mahns. (2020) Minocycline reduces experimental muscle hyperalgesia induced by repeated nerve growth factor injections in humans: A placebo‐controlled double‐blind drug‐crossover study. European Journal of Pain 24:6, pages 1138-1150.
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Xin Wei, Cheng Sun, Ren-Peng Zhou, Gang-Gang Ma, Yang Yang, Chao Lu & Wei Hu. (2020) Nerve growth factor promotes ASIC1a expression via the NF-κB pathway and enhances acid-induced chondrocyte apoptosis. International Immunopharmacology 82, pages 106340.
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Mythili Dileepan, Xiao Na Ge, Idil Bastan, Yana G. Greenberg, Yuying Liang, P. Sriramarao & Savita P. Rao. (2020) Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A. The Journal of Immunology 204:3, pages 682-693.
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Paula Dakin, Stephen J. DiMartino, Haitao Gao, Jennifer Maloney, Alan J. Kivitz, Thomas J. Schnitzer, Neil Stahl, George D. Yancopoulos & Gregory P. Geba. (2019) The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Double‐Blind, Placebo‐Controlled, Randomized Clinical Trial. Arthritis & Rheumatology 71:11, pages 1824-1834.
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Dario Kringel, Mari A. Kaunisto, Eija Kalso & Jörn Lötsch. (2019) Machine-learned analysis of the association of next-generation sequencing–based genotypes with persistent pain after breast cancer surgery. Pain 160:10, pages 2263-2277.
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Neal Slatkin, Naim Zaki, Steven Wang, John Louie, Panna Sanga, Kathleen M. Kelly & John Thipphawong. (2019) Fulranumab as Adjunctive Therapy for Cancer-Related Pain: A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study. The Journal of Pain 20:4, pages 440-452.
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Sagar Singh, Sonia Kartha, Ben A. Bulka, Nicholas S. Stiansen & Beth A. Winkelstein. (2019) Physiologic facet capsule stretch can induce pain & upregulate matrix metalloproteinase-3 in the dorsal root ganglia when preceded by a physiological mechanical or nonpainful chemical exposure. Clinical Biomechanics 64, pages 122-130.
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Tommaso Castroflorio, Andrea Bargellini, Andrea Deregibus & Peter Svensson. 2019. Contemporary Oral Medicine. Contemporary Oral Medicine 1843 1880 .
Dario Kringel, Mari A. Kaunisto, Catharina Lippmann, Eija Kalso & Jörn Lötsch. (2018) Development of an AmpliSeqTM Panel for Next-Generation Sequencing of a Set of Genetic Predictors of Persisting Pain. Frontiers in Pharmacology 9.
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Theodore J Price & Michael S Gold. (2018) From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain. Pain Medicine 19:8, pages 1525-1549.
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Angélica V. Medina-Cucurella, Yaqi Zhu, Scott J. Bowen, Lisa M. Bergeron & Timothy A. Whitehead. (2018) Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti-NGF monoclonal antibodies. Biotechnology and Bioengineering 115:8, pages 1925-1937.
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Sara Nencini, Mitchell Ringuet, Dong-Hyun Kim, Claire Greenhill & Jason J. Ivanusic. (2018) GDNF, Neurturin, and Artemin Activate and Sensitize Bone Afferent Neurons and Contribute to Inflammatory Bone Pain. The Journal of Neuroscience 38:21, pages 4899-4911.
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Olga Krupkova, Lucas Smolders, Karin Wuertz-Kozak, James Cook & Antonio Pozzi. (2018) The Pathobiology of the Meniscus: A Comparison Between the Human and Dog. Frontiers in Veterinary Science 5.
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Laura A. Carleton, Reka Chakravarthy, Almer M. van der Sloot, Katarzyna Mnich, Luis Serrano, Afshin Samali & Adrienne M. Gorman. (2018) Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity. Biochemical and Biophysical Research Communications 495:1, pages 700-705.
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Jason J. Ivanusic. (2017) Molecular Mechanisms That Contribute to Bone Marrow Pain. Frontiers in Neurology 8.
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Marc Nugent, Jiafu Wang, Gary Lawrence, Tomas Zurawski, Joan A. Geoghegan & J. Oliver Dolly. (2017) Conjugate of an IgG Binding Domain with Botulinum Neurotoxin A Lacking the Acceptor Moiety Targets Its SNARE Protease into TrkA-Expressing Cells When Coupled to Anti-TrkA IgG or Fc-βNGF. Bioconjugate Chemistry 28:6, pages 1684-1692.
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Theodoros Dimitroulas, Tosin Lambe, Rainer Klocke, George D. Kitas & Rui V. Duarte. (2017) Biologic drugs as analgesics for the management of osteoarthritis. Seminars in Arthritis and Rheumatism 46:6, pages 687-691.
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Danielle M. Hurzy, Darrell A. Henze, Tamara D. Cabalu, Kartik Narayan, Amanda Heller & Andrew J. Cooke. (2017) Design, synthesis and SAR of substituted indoles as selective TrkA inhibitors. Bioorganic & Medicinal Chemistry Letters 27:12, pages 2695-2701.
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Thimios A. Mitsiadis, Henry Magloire & Pierfrancesco Pagella. (2017) Nerve growth factor signalling in pathology and regeneration of human teeth. Scientific Reports 7:1.
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Bryan H. Norman & Jeff S. McDermott. (2016) Targeting the Nerve Growth Factor (NGF) Pathway in Drug Discovery. Potential Applications to New Therapies for Chronic Pain. Journal of Medicinal Chemistry 60:1, pages 66-88.
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Peng Yao, Yuanyuan Ding, Zhenkai Han, Ying Mu, Tao Hong, Yongqiang Zhu & Hongxi Li. (2017) Suppression of asparaginyl endopeptidase attenuates breast cancer-induced bone pain through inhibition of neurotrophin receptors. Molecular Pain 13, pages 174480691770812.
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