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Review

Current perspectives on intrathecal drug delivery

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Pages 615-626 | Published online: 06 Nov 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Derfogail Delcassian, Asha K. Patel, Abel B. Cortinas & Robert Langer. (2019) Drug delivery across length scales. Journal of Drug Targeting 27:3, pages 229-243.
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Roberto Giugliani, Amauri Dalla Corte, Fabiano Poswar, Cláudia Vanzella, Dafne Horovitz, Mariluce Riegel, Guilherme Baldo & Filippo Vairo. (2018) Intrathecal/Intracerebroventricular enzyme replacement therapy for the mucopolysaccharidoses: efficacy, safety, and prospects. Expert Opinion on Orphan Drugs 6:7, pages 403-411.
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Gladstone C. McDowell$suffix/text()$suffix/text() & Joseph Winchell. (2018) Role of primary care physicians in intrathecal pain management: a narrative review of the literature. Postgraduate Medicine 130:4, pages 411-419.
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Jeremy A Adler & Neona M Lotz. (2017) Intrathecal pain management: a team-based approach. Journal of Pain Research 10, pages 2565-2575.
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G. Pizzichelli, B. Kehlet, Ø. Evju, B. A. Martin, M. E. Rognes, K. A. Mardal & E. Sinibaldi. (2017) Numerical study of intrathecal drug delivery to a permeable spinal cord: effect of catheter position and angle. Computer Methods in Biomechanics and Biomedical Engineering 20:15, pages 1599-1608.
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Muhammet Enes Gündüz, Finn Haak, Veerle Visser-Vandewalle & Georgios Matis. Dose escalation in intrathecal baclofen therapy based on disease etiology: Can an a priori target dose be established? A ten-year follow-up study. The Journal of Spinal Cord Medicine 0:0, pages 1-7.
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Prajwal P. Thakre, Sabhya Rana, Ethan S. Benevides & David D. Fuller. (2023) Targeting drug or gene delivery to the phrenic motoneuron pool. Journal of Neurophysiology 129:1, pages 144-158.
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Subhi Marwari, Cody Kowalski & Kirill A. Martemyanov. (2022) Exploring pharmacological inhibition of G q/11 as an analgesic strategy . British Journal of Pharmacology 179:23, pages 5196-5208.
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Magdalena Markowicz-Piasecka, Patrycja Darłak, Agata Markiewicz, Joanna Sikora, Santosh Kumar Adla, Sreelatha Bagina & Kristiina M. Huttunen. (2022) Current approaches to facilitate improved drug delivery to the central nervous system. European Journal of Pharmaceutics and Biopharmaceutics 181, pages 249-262.
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Sérgio Pinho, Anabela Ferreira, Duarte Calado, Madjer Hatia & Filipa Faria. (2022) Ultrasound-Guided Intrathecal Baclofen Pump Refilling Method for Management of Spasticity in a Complex Clinical Case. Cureus.
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Brittanie Partridge, Allison Eardley, Brianna E. Morales, Sabrina N. Campelo, Melvin F. Lorenzo, Jason N. Mehta, Yukitaka Kani, Josefa K. Garcia Mora, Etse-Oghena Y. Campbell, Christopher B. Arena, Simon Platt, Akiva Mintz, Richard L. Shinn, Christopher G. Rylander, Waldemar Debinski, Rafael V. Davalos & John H. Rossmeisl. (2022) Advancements in drug delivery methods for the treatment of brain disease. Frontiers in Veterinary Science 9.
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Amel Djoudi, Rodolfo Molina-Peña, Natalia Ferreira, Ilaria Ottonelli, Giovanni Tosi, Emmanuel Garcion & Frank Boury. (2022) Hyaluronic Acid Scaffolds for Loco-Regional Therapy in Nervous System Related Disorders. International Journal of Molecular Sciences 23:20, pages 12174.
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Akari Seiner, Goutham Kumar Reddy Burla, Dev Shrestha, Mayumi Bowen, Joshua D. Horvath & Bryn A. Martin. (2022) Investigation of Human Intrathecal Solute Transport Dynamics Using a Novel in vitro Cerebrospinal Fluid System Analog. Frontiers in Neuroimaging 1.
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Yamaan S Saadeh, Eleanor Smith, Juliana M Bilowus, Joseph R Linzey, Zoey Chopra & Paul Park. (2022) Intrathecal Medication From Pain Pump Caused Prolonged Alteration in Mental Status Following Decompression of Severe Spinal Stenosis. Cureus.
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Fred C. Lam, Fateme Salehi & Ekkehard M. Kasper. (2022) Integrating Nanotechnology in Neurosurgery, Neuroradiology, and Neuro-Oncology Practice—The Clinicians’ Perspective. Frontiers in Bioengineering and Biotechnology 10.
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Seoyeon Kim & Min Kyoung Kang. (2021) Morphine overinfusion of intrathecal drug administration system under magnetic resonance evaluation for the diagnosis of stroke: a case report. BMC Neurology 21:1.
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Chang Sun, Yu-Tong Wang, Yu-Jie Dai, Zhi-Hui Liu, Jing Yang, Zhu-Qiang Cheng, Dao-Song Dong, Cheng-Fu Wang, Guo-Li Zhao, Gui-Jun Lu, Tao Song, Yi Jin, Alan D. Kaye, Farnad Imani, Kambiz Sadegi, Li-Li Sun & Yong-Hai Sun. (2021) Programmable Pump for Intrathecal Morphine Delivery to Cisterna Magna: Clinical Implications in Novel Management of Refractory Pain Above Middle Thoracic Vertebrae Level Utilizing a Prospective Trial Protocol and Review. Anesthesiology and Pain Medicine 11:3.
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J Procházka, A Hejčl & L Procházková. (2021) Our article after ten years: Intrathecal midazolam as supplementary analgesia for chronic lumbar pain - 15 years'experience. Anesteziologie a intenzivní medicína 32:2, pages 94-98.
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В.В. Алексеевец, С.А. Лихачев, Н.А. Наумовская & В.П. Боярчик. (2021) Chronic Intrathecal Administration of Analgesics (Literature Review, Clinical Example). Неврология и нейрохирургия. Восточная Европа:4, pages 597-605.
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Jack Price. (2020) Cell therapy approaches to autism: a review of clinical trial data. Molecular Autism 11:1.
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Maximilian Bschorer, Mauricio Martinez-Moreno, Marc Tietke & Oliver Heese. (2020) The Management of Unresectable Intrathecal Catheter-Tip-Associated Granuloma Using Morphine Therapy Cessation and Spinal Cord Stimulation. Cureus.
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Eleonora Ficiarà, Shoeb Anwar Ansari, Monica Argenziano, Luigi Cangemi, Chiara Monge, Roberta Cavalli & Federico D’Agata. (2020) Beyond Oncological Hyperthermia: Physically Drivable Magnetic Nanobubbles as Novel Multipurpose Theranostic Carriers in the Central Nervous System. Molecules 25:9, pages 2104.
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Barbara A. Perez, Alison Shutterly, Ying Kai Chan, Barry J. Byrne & Manuela Corti. (2020) Management of Neuroinflammatory Responses to AAV-Mediated Gene Therapies for Neurodegenerative Diseases. Brain Sciences 10:2, pages 119.
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Gilles Allano, Brigitte George, Christian Minello, Alexis Burnod, Caroline Maindet & Antoine Lemaire. (2019) Strategies for interventional therapies in cancer-related pain—a crossroad in cancer pain management. Supportive Care in Cancer 27:8, pages 3133-3145.
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Fernanda P. Pons-Faudoa, Andrea Ballerini, Jason Sakamoto & Alessandro Grattoni. (2019) Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases. Biomedical Microdevices 21:2.
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Corey W. Hunter & Dipan Patel. 2019. Deer's Treatment of Pain. Deer's Treatment of Pain 699 706 .
Jianning Shao, Leonardo Frizon, Andre G. Machado, Keith McKee, Francois Bethoux, Jennifer Hartman & Sean J. Nagel. (2018) Occlusion of the Ascenda Catheter in a Patient with Pump Twiddler’s Sydrome: A Case Report. Anesthesiology and Pain Medicine 8:2.
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Bård Lundeland, Lars Janerås & Gunnvald Kvarstein. (2017) Severe side effects from intrathecal morphine for chronic pain after repeated failed spinal operations. Scandinavian Journal of Pain 17:1, pages 150-151.
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Kehua Zhou, Sen Sheng & Gary G. Wang. (2017) Management of patients with pain and severe side effects while on intrathecal morphine therapy: A case study. Scandinavian Journal of Pain 17:1, pages 37-40.
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Alexis M. Ziemba & Ryan J. Gilbert. (2017) Biomaterials for Local, Controlled Drug Delivery to the Injured Spinal Cord. Frontiers in Pharmacology 8.
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Jonathan M. Hagedorn & George Atallah. (2017) Intrathecal management of complex regional pain syndrome: A case report and literature. Scandinavian Journal of Pain 14:1, pages 110-112.
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Joseph F. Nabhan, Kristy M. Wood, Varada P. Rao, Jeffrey Morin, Surya Bhamidipaty, Timothy P. LaBranche, Renea L. Gooch, Fazli Bozal, Christine E. Bulawa & Braydon C. Guild. (2016) Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia. Scientific Reports 6:1.
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