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Original Research

Fear of pain potentiates nocebo hyperalgesia

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Pages 703-710 | Published online: 12 Oct 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Tessa Rooney, Louise Sharpe, Jemma Todd, Bethany Richmond & Ben Colagiuri. (2023) The relationship between expectancy, anxiety, and the nocebo effect: a systematic review and meta-analysis with recommendations for future research. Health Psychology Review 17:4, pages 550-577.
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K D Bharwani, A B Kersten, A L Stone, F Birklein, S Bruehl, M Dirckx, P D Drummond, J Gierthmühlen, A Goebel, L Knudsen & F J P M Huygen. (2021) Denying the Truth Does Not Change the Facts: A Systematic Analysis of Pseudoscientific Denial of Complex Regional Pain Syndrome. Journal of Pain Research 14, pages 3359-3376.
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Sara M Vambheim & Magne Arve Flaten. (2017) A systematic review of sex differences in the placebo and the nocebo effect. Journal of Pain Research 10, pages 1831-1839.
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Sara M Vambheim, Peter Solvoll Lyby, Per M Aslaksen, Magne Arve Flaten, Ole Åsli & Laila M Martinussen. (2017) The Fear of Pain Questionnaire-III and the Fear of Pain Questionnaire-Short Form: a confirmatory factor analysis. Journal of Pain Research 10, pages 1871-1878.
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Lars Björkman, Therese T. Sjursen, Knut Dalen, Gunvor B. Lygre, Trine Lise L. Berge, Johanna Svahn & Birgitte F. Lundekvam. (2017) Long term changes in health complaints after removal of amalgam restorations. Acta Odontologica Scandinavica 75:3, pages 208-219.
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Joseph S. Blythe, Mia A. Thomaidou, Kaya J. Peerdeman, Antoinette I.M. van Laarhoven, Myrthe M.E. van Schothorst, Dieuwke S. Veldhuijzen & Andrea W.M. Evers. (2023) Placebo effects on cutaneous pain and itch: a systematic review and meta-analysis of experimental results and methodology. Pain 164:6, pages 1181-1199.
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Angelika Kunkel & Ulrike Bingel. (2023) Placeboeffekte in der SchmerztherapiePlacebo effects in analgesia. Der Schmerz 37:1, pages 59-71.
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Branka Bagarić, Nataša Jokić-Begić & Claire Sangster Jokić. (2021) The Nocebo Effect: A Review of Contemporary Experimental Research. International Journal of Behavioral Medicine 29:3, pages 255-265.
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Suzanne G. Helfer, Ben Colagiuri, Kate Faasse, Kelly S. Clemens, Fawn Caplandies & Andrew L. Geers. (2022) The influence of message framing on nocebo headaches: Findings from a randomized laboratory design. Journal of Behavioral Medicine 45:3, pages 438-450.
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Gerardo La Monaca, Nicola Pranno, Susanna Annibali, Antonella Polimeni, Giorgio Pompa & Maria Paola Cristalli. (2021) Effects of ibuprofen administration timing on oral surgery pain: A randomized clinical trial. Oral Diseases 28:3, pages 796-804.
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Eleonora Maria Camerone, Simone Battista, Fabrizio Benedetti, Elisa Carlino, Lucia Grazia Sansone, Luca Buzzatti, Aldo Scafoglieri & Marco Testa. (2022) The Temporal Modulation of Nocebo Hyperalgesia in a Model of Sustained Pain. Frontiers in Psychiatry 13.
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K. Arrow, L. L. Burgoyne & A. M. Cyna. (2022) Implications of nocebo in anaesthesia care. Anaesthesia 77:S1, pages 11-20.
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Stefanie H. Meeuwis, Henriët van Middendorp, Dieuwke S. Veldhuijzen & Andrea W. M. Evers. (2021) Associations Between Interindividual Differences, Expectations and Placebo and Nocebo Effects in Itch. Frontiers in Psychology 12.
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Anders Deichmann Springborg, Caitlin Rae Wessel, Lars Peter Kloster Andersen & Mads Utke Werner. (2021) Methodology and applicability of the human contact burn injury model: A systematic review. PLOS ONE 16:7, pages e0254790.
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Hansen Li, Xing Zhang, Shilin Bi, Yang Cao & Guodong Zhang. (2021) Can Residential Greenspace Exposure Improve Pain Experience? A Comparison between Physical Visit and Image Viewing. Healthcare 9:7, pages 918.
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Hojjat Daniali & Magne Arve Flaten. (2021) What Psychological Factors Make Individuals Believe They Are Infected by Coronavirus 2019?. Frontiers in Psychology 12.
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Andrew L. Geers, Kate Faasse, Darwin A. Guevarra, Kelly S. Clemens, Suzanne G. Helfer & Ben Colagiuri. (2020) Affect and emotions in placebo and nocebo effects: What do we know so far?. Social and Personality Psychology Compass 15:1.
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Mia Athina Thomaidou, Dieuwke Swaantje Veldhuijzen, Ann Meulders & Andrea Walburga Maria Evers. (2021) An experimental investigation into the mediating role of pain-related fear in boosting nocebo hyperalgesia. Pain 162:1, pages 287-299.
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Hojjat Daniali & Magne Arve Flaten. (2020) Placebo Analgesia, Nocebo Hyperalgesia, and the Cardiovascular System: A Qualitative Systematic Review. Frontiers in Physiology 11.
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Ulrike Bingel. (2020) Placebo 2.0: the impact of expectations on analgesic treatment outcome. Pain 161:Supplement 1, pages S48-S56.
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Susann Dahl Pettersen, Per M. Aslaksen & Svein Arne Pettersen. (2020) Pain Processing in Elite and High-Level Athletes Compared to Non-athletes. Frontiers in Psychology 11.
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Mia Athina Thomaidou, Dieuwke Swaantje Veldhuijzen, Kaya Joanne Peerdeman, Naomi Zoë Sifra Wiebing, Joseph Sullivan Blythe & Andrea Walbruga Maria Evers. (2020) Learning mechanisms in nocebo hyperalgesia: the role of conditioning and extinction processes. Pain 161:7, pages 1597-1608.
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Elżbieta A Bajcar, Karolina Wiercioch-Kuzianik, Wacław M Adamczyk & Przemysław Bąbel. (2020) To Experience or to Be Informed? Classical Conditioning Induces Nocebo Hyperalgesia even when Placebo Analgesia Is Verbally Suggested—Results of a Preliminary Study. Pain Medicine 21:3, pages 548-560.
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Alexandra Kern, Christoph Kramm, Claudia M. Witt & Jürgen Barth. (2020) The influence of personality traits on the placebo/nocebo response. Journal of Psychosomatic Research 128, pages 109866.
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Ulrike Bingel. 2020. The Senses: A Comprehensive Reference. The Senses: A Comprehensive Reference 801 807 .
Nelda Itzep & Vivien Sheehan. 2020. Hematology in the Adolescent Female. Hematology in the Adolescent Female 217 225 .
Andrew L Geers, Shane Close, Fawn C Caplandies & Lene Vase. (2019) A Positive Mood Induction for Reducing the Formation of Nocebo Effects from Side Effect Information. Annals of Behavioral Medicine 53:11, pages 999-1008.
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Andrew L. GeersShane CloseFawn C. CaplandiesCharles L. VogelAshley B. MurrayYopina PertiwiIan M. HandleyLene Vase. (2019) Testing a positive-affect induction to reduce verbally induced nocebo hyperalgesia in an experimental pain paradigm. Pain 160:10, pages 2290-2297.
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Hojjat Daniali & Magne Arve Flaten. (2019) A Qualitative Systematic Review of Effects of Provider Characteristics and Nonverbal Behavior on Pain, and Placebo and Nocebo Effects. Frontiers in Psychiatry 10.
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Sigrid Elsenbruch, Till Roderigo, Paul Enck & Sven Benson. (2019) Can a Brief Relaxation Exercise Modulate Placebo or Nocebo Effects in a Visceral Pain Model?. Frontiers in Psychiatry 10.
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Gyongyi Kokonyei, Attila Galambos, Andrea Edit Edes, Natalia Kocsel, Edina Szabo, Dorottya Pap, Lajos R. Kozak, Gyorgy Bagdy & Gabriella Juhasz. (2018) Anticipation and violated expectation of pain are influenced by trait rumination: An fMRI study. Cognitive, Affective, & Behavioral Neuroscience 19:1, pages 56-72.
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Karolina Wartolowska. (2019) The nocebo effect as a source of bias in the assessment of treatment effects. F1000Research 8, pages 5.
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Elżbieta A. Bajcar & Przemysław Bąbel. (2018) How Does Observational Learning Produce Placebo Effects? A Model Integrating Research Findings. Frontiers in Psychology 9.
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Ben Colagiuri & Veronica F. Quinn. (2018) Autonomic Arousal as a Mechanism of the Persistence of Nocebo Hyperalgesia. The Journal of Pain 19:5, pages 476-486.
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June T. Forsberg, Johannes Gjerstad, Magne Arve Flaten & Per M. Aslaksen. (2017) Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia. Pain 159:1, pages 168-174.
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Sigrid Elsenbruch & Franziska Labrenz. 2018. Neurobiology of the Placebo Effect Part I. Neurobiology of the Placebo Effect Part I 285 306 .
Maxie Blasini, Nicole Corsi & Luana Colloca. 2018. Handbook of Pain and Palliative Care. Handbook of Pain and Palliative Care 317 336 .
Anne-Kathrin Bräscher, Dieter Kleinböhl, Rupert Hölzl & Susanne Becker. (2017) Differential Classical Conditioning of the Nocebo Effect: Increasing Heat-Pain Perception without Verbal Suggestions. Frontiers in Psychology 8.
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Till Roderigo, Sven Benson, Margarita Schöls, Madeleine Hetkamp, Manfred Schedlowski, Paul Enck & Sigrid Elsenbruch. (2017) Effects of acute psychological stress on placebo and nocebo responses in a clinically relevant model of visceroception. Pain 158:8, pages 1489-1498.
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C. Richard Chapman & Charles J. Vierck. (2017) The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms. The Journal of Pain 18:4, pages 359.e1-359.e38.
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Nicole Corsi & Luana Colloca. (2017) Placebo and Nocebo Effects: The Advantage of Measuring Expectations and Psychological Factors. Frontiers in Psychology 8.
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Maxie Blasini, Nicole Corsi, Regine Klinger & Luana Colloca. (2017) Nocebo and pain: an overview of the psychoneurobiological mechanisms. PAIN Reports 2:2, pages e585.
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Per M. Aslaksen, Ole Åsli, Morten Øvervoll & Espen Bjørkedal. (2016) Nocebo hyperalgesia and the startle response. Neuroscience 339, pages 599-607.
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Sergiu Albu & Mary W. Meagher. (2016) Expectation of nocebo hyperalgesia affects EEG alpha-activity. International Journal of Psychophysiology 109, pages 147-152.
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Xiulu Ruan. (2016) Balancing placebo and nocebo effects during electromyography in children. Muscle & Nerve 54:4, pages 811-811.
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