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Review

Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine

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Pages 31-47 | Published online: 12 Jul 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Hemant Kumar, Suraj Kumar Mandal, Prerana Gogoi & Shankar Prasad Kanaujia. (2022) Structural and functional role of invariant water molecules in matrix metalloproteinases: a data-mining approach. Journal of Biomolecular Structure and Dynamics 40:20, pages 10074-10085.
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Tuomo Karila, Taina Tervahartiala, Beniamin Cohen & Timo Sorsa. (2022) The collagenases: are they tractable targets for preventing cartilage destruction in osteoarthritis?. Expert Opinion on Therapeutic Targets 26:2, pages 93-105.
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Tyler Duellman, Andrea Doll, Xi Chen, Rie Wakamiya & Jay Yang. (2017) dCas9-mediated transcriptional activation of tissue inhibitor of metalloproteinases. Metalloproteinases in Medicine 4, pages 63-73.
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Grazia Luisi, Guido Angelini, Carla Gasbarri, Antonio Laghezza, Mariangela Agamennone, Fulvio Loiodice, Claudiu T. Supuran, Cristina Campestre & Paolo Tortorella. (2017) Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrases by chiral N-(biarylsulfonyl)-phosphonic acids. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 1260-1264.
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Patrick Henriet, Khin Su Mon & Etienne Marbaix. (2016) Are matrix metalloproteinases and their inhibitors reliable diagnosis biomarkers and attractive therapeutic targets in endometriosis?. Metalloproteinases in Medicine 3, pages 81-92.
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Articles from other publishers (22)

Ioakeim Giagtzidis, Christos Karkos, Nikos P.E. Kadoglou, Aris Spathis & Konstantinos Papazoglou. (2023) Serum Levels of Matrix Metalloproteinases in Patients Undergoing Endovascular Intervention for Peripheral Arterial Disease. Annals of Vascular Surgery 94, pages 154-164.
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A. V. Shevchenko, V. F. Prokofiev, V. I. Konenkov, V. V. Chernykh, O. V. Ermakova & A. N. Trunov. (2023) Complex studies on gene polymorphisms of MMP2, MMP3, MMP9 matrix metalloproteinases and TIMP1, TIMP2 tissue inhibitors of metalloproteinases in the patients with primary open-angle glaucoma. Medical Immunology (Russia) 25:2, pages 331-338.
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Tewodros Shibabaw, Banchamlak Teferi & Birhanu Ayelign. (2023) The role of Th-17 cells and IL-17 in the metastatic spread of breast cancer: As a means of prognosis and therapeutic target. Frontiers in Immunology 14.
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Florentina Daraban Bocaneti, Gennaro Altamura, Annunziata Corteggio, Oana Irina Tanase, Mihaela Anca Dascalu, Sorin Aurelian Pasca, Ozana Hritcu, Mihai Mares & Giuseppe Borzacchiello. (2023) Expression of collagenases (matrix metalloproteinase-1, -8, -13) and tissue inhibitor of metalloproteinase-3 (TIMP-3) in naturally occurring bovine cutaneous fibropapillomas. Frontiers in Veterinary Science 9.
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Hao Li, Karin Staxäng, Monika Hodik, Karl-Gunnar Melkersson, Mathias Rask-Andersen & Helge Rask-Andersen. (2022) Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Crocodylus rhombifer and Osteolaemus tetraspis) Can We Learn From the Crocodile How to Restore Our Hearing?. Frontiers in Cell and Developmental Biology 10.
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Hezi Hayun, Valeria Arkadash, Amiram Sananes, Eyal Arbely, David Stepensky & Niv Papo. (2022) Bioorthogonal PEGylation Prolongs the Elimination Half-Life of N-TIMP2 While Retaining MMP Inhibition. Bioconjugate Chemistry 33:5, pages 795-806.
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Sumaer Kamboj, Chase Harms, Derek Wright, Anthony Nash, Lokender Kumar, Judith Klein-Seetharaman & Susanta K. Sarkar. (2022) Identification of allosteric fingerprints of alpha-synuclein aggregates in matrix metalloprotease-1 and substrate-specific virtual screening with single molecule insights. Scientific Reports 12:1.
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Edwin Leong, Michael Bezuhly & Jean S. Marshall. (2021) Distinct Metalloproteinase Expression and Functions in Systemic Sclerosis and Fibrosis: What We Know and the Potential for Intervention. Frontiers in Physiology 12.
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Ellen M. Adams, Simone Pezzotti, Jonas Ahlers, Maximilian Rüttermann, Maxim Levin, Adi Goldenzweig, Yoav Peleg, Sarel J. Fleishman, Irit Sagi & Martina Havenith. (2021) Local Mutations Can Serve as a Game Changer for Global Protein Solvent Interaction. JACS Au 1:7, pages 1076-1085.
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O. O. Shakhmatova, A. L. Komarov, V. V. Korobkova, E. B. Yarovaya, M. V. Andreevskaya, A. G. Shuleshova & E. P. Panchenko. (2020) Upper gastrointestinal bleeding in patients with stable coronary artery disease (registry of antithrombotic therapy “REGATТA” results). Terapevticheskii arkhiv 92:9, pages 30-38.
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Weiqi Xia & Chunqi Hu. (2020) Progress in Research on Tumor Metastasis Inhibitors. Current Medicinal Chemistry 27:34, pages 5758-5772.
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Pauline Zipfel, Christophe Rochais, Kévin Baranger, Santiago Rivera & Patrick Dallemagne. (2020) Matrix Metalloproteinases as New Targets in Alzheimer’s Disease: Opportunities and Challenges. Journal of Medicinal Chemistry 63:19, pages 10705-10725.
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Ross D. Vasquez & Stephen Lirio. (2020) Content Analysis, Cytotoxic, and Anti-metastasis Potential of Bioactive Polysaccharides from Green Alga Codium intricatum Okamura. Current Bioactive Compounds 16:3, pages 320-328.
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Vishnu Mohan, Alakesh Das & Irit Sagi. (2020) Emerging roles of ECM remodeling processes in cancer. Seminars in Cancer Biology 62, pages 192-200.
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Subha Mondal, Nilanjan Adhikari, Suvankar Banerjee, Sk Abdul Amin & Tarun Jha. (2020) Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview. European Journal of Medicinal Chemistry 194, pages 112260.
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Kang Li, Franklin R. Tay & Cynthia Kar Yung Yiu. (2020) The past, present and future perspectives of matrix metalloproteinase inhibitors. Pharmacology & Therapeutics 207, pages 107465.
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Mohammed Salah Ayoup, Manar Ahmed Fouad, Hamida Abdel-Hamid, El Sayed Ramadan, Marwa M. Abu-Serie, Ahmed Noby & Mohamed Teleb. (2020) Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis. European Journal of Medicinal Chemistry 186, pages 111875.
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Fathima Fazrina Farook, Mohamed Nuzaim M. Nizam & Abdulsalam Alshammari. (2019) An Update on the Mechanisms of Phenytoin Induced Gingival Overgrowth. The Open Dentistry Journal 13:1, pages 430-435.
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Nir Hananya, Ofir Press, Alakesh Das, Anna Scomparin, Ronit Satchi‐Fainaro, Irit Sagi & Doron Shabat. (2019) Persistent Chemiluminescent Glow of Phenoxy‐dioxetane Luminophore Enables Unique CRET‐Based Detection of Proteases. Chemistry – A European Journal 25:64, pages 14679-14687.
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Nikolaos A. Afratis, Moises Selman, Annie Pardo & Irit Sagi. (2018) Emerging insights into the role of matrix metalloproteases as therapeutic targets in fibrosis. Matrix Biology 68-69, pages 167-179.
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Sabrina Amar, Lyndsay Smith & Gregg B. Fields. (2017) Matrix metalloproteinase collagenolysis in health and disease. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:11, pages 1940-1951.
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Charlton Lam, Melissa Jamerson, Guy Cabral, Ana Maris Carlesso & Francine Marciano-Cabral. (2017) Expression of matrix metalloproteinases in Naegleria fowleri and their role in invasion of the central nervous system. Microbiology 163:10, pages 1436-1444.
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