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Neuropsychiatric Disease and Treatment Volume 12, 2016 - Issue
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Original Research

Baicalein improves behavioral dysfunction induced by Alzheimer’s disease in rats

Li ZhouDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
,
Sha TanDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
,
Yi-long ShanDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
,
Yu-ge WangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
,
Wei CaiDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
,
Xue-hong HuangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
,
Xi-yuan LiaoDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
,
Hai-yan LiDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
,
Lei ZhangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
,
Bing-jun ZhangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of China
&
Zheng-qi LuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 3145-3152 | Published online: 09 Dec 2016

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Yasmin S. Abulfadl, Nabila .N. El-Maraghy, Amany Ali. Eissa Ahmed, Shahira Nofal & Osama A. Badary. (2018) Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes. Neurological Research 40:4, pages 324-333.
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Articles from other publishers (19)

Ratnakar Jadhav & Yogesh A. Kulkarni. (2023) The Combination of Baicalein and Memantine Reduces Oxidative Stress and Protects against β-amyloid-Induced Alzheimer’s Disease in Rat Model. Antioxidants 12:3, pages 707.
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Ratnakar Jadhav & Yogesh A. Kulkarni. (2023) Effects of baicalein with memantine on aluminium chloride-induced neurotoxicity in Wistar rats. Frontiers in Pharmacology 14.
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Sun Meng-zhen, Li Ju, Zhang Lan-chun, Ding Cai-feng, Yang Shu-da, Yu Hao-fei & Hu Wei-yan. (2022) Potential therapeutic use of plant flavonoids in AD and PD. Heliyon 8:11, pages e11440.
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Ali Ahmadi, Zoha Mortazavi, Soghra Mehri & Hossein Hosseinzadeh. (2022) Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review. Naunyn-Schmiedeberg's Archives of Pharmacology 395:11, pages 1297-1329.
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Biswajit Chakraborty, Nobendu Mukerjee, Swastika Maitra, Mehrukh Zehravi, Dattatreya Mukherjee, Arabinda Ghosh, Ehab El Sayed Massoud & Md. Habibur Rahman. (2022) Therapeutic Potential of Different Natural Products for the Treatment of Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity 2022, pages 1-18.
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Yijing Liao, Xing Hu, Junhui Pan & Guowen Zhang. (2022) Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation. Foods 11:2, pages 168.
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Umesh Chandra Dash, Sandeep Kumar Swain, Satish Kanhar, Purusottam Banjare, Partha Pratim Roy, Jagneshwar Dandapat & Atish Kumar Sahoo. (2022) The modulatory role of prime identified compounds in Geophila repens in mitigating scopolamine-induced neurotoxicity in experimental rats of Alzheimer's disease via attenuation of cholinesterase, β-secretase, MAPt levels and inhibition of oxidative stress imparts inflammation. Journal of Ethnopharmacology 282, pages 114637.
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Raafat A. Abdel-Aal, Ola A. Hussein, Reham G. Elsaady & Lobna A. Abdelzaher. (2022) Naproxen as a potential candidate for promoting rivastigmine anti-Alzheimer activity against aluminum chloride-prompted Alzheimer's-like disease in rats; neurogenesis and apoptosis modulation as a possible underlying mechanism. European Journal of Pharmacology 915, pages 174695.
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Ion Brinza, Iriny M. Ayoub, Omayma A. Eldahshan & Lucian Hritcu. (2021) Baicalein 5,6-Dimethyl Ether Prevents Memory Deficits in the Scopolamine Zebrafish Model by Regulating Cholinergic and Antioxidant Systems. Plants 10:6, pages 1245.
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Tayebeh Noori, Ahmad Reza Dehpour, Antoni Sureda, Eduardo Sobarzo-Sanchez & Samira Shirooie. (2021) Role of natural products for the treatment of Alzheimer's disease. European Journal of Pharmacology 898, pages 173974.
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Shweta Kishor Sonawane, Vladimir N. Uversky & Subashchandrabose Chinnathambi. (2021) Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation. Cell Communication and Signaling 19:1.
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Zhiling Fang, Yuqing Tang, Jiaming Ying, Chunlan Tang & Qinwen Wang. (2020) Traditional Chinese medicine for anti-Alzheimer’s disease: berberine and evodiamine from Evodia rutaecarpa. Chinese Medicine 15:1.
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Jin Han, Yeongseon Ji, Kumju Youn, GyuTae Lim, Jinhyuk Lee, Dong Hyun Kim & Mira Jun. (2019) Baicalein as a Potential Inhibitor against BACE1 and AChE: Mechanistic Comprehension through In Vitro and Computational Approaches. Nutrients 11:11, pages 2694.
Crossref
Qin Li, Qiu-Qi Li, Ji-Ning Jia, Qian-Yi Sun, Hong-Hao Zhou, Wei-Lin Jin & Xiao-Yuan Mao. (2019) Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis. Frontiers in Pharmacology 10.
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Laraib Liaquat, Sadia Sadir, Zehra Batool, Saiqa Tabassum, Sidrah Shahzad, Asia Afzal & Saida Haider. (2019) Acute aluminum chloride toxicity revisited: Study on DNA damage and histopathological, biochemical and neurochemical alterations in rat brain. Life Sciences 217, pages 202-211.
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Neha Falls, Deepika Singh, Firoz Anwar, Amita Verma & Vikas Kumar. (2018) Amelioration of neurodegeneration and cognitive impairment by Lemon oil in experimental model of Stressed mice. Biomedicine & Pharmacotherapy 106, pages 575-583.
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Ana Ferreira, Adriana O. Santos, Amílcar Falcão & Gilberto Alves. (2018) In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance: Focus on antiepileptic drugs. Food and Chemical Toxicology 111, pages 84-93.
Crossref
Kandhasamy Sowndhararajan, Ponnuvel Deepa, Minju Kim, Se Jin Park & Songmun Kim. (2017) Baicalein as a potent neuroprotective agent: A review. Biomedicine & Pharmacotherapy 95, pages 1021-1032.
Crossref
Yanwei Li, Jinying Zhao & Christian Hölscher. (2017) Therapeutic Potential of Baicalein in Alzheimer’s Disease and Parkinson’s Disease. CNS Drugs 31:8, pages 639-652.
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