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Review

Neuroleptic malignant syndrome: an easily overlooked neurologic emergency

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Pages 161-175 | Published online: 16 Jan 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Anna Maria Szota, Izabela Radajewska & Aleksander Stanisław Araszkiewicz. (2022) Atypical Neuroleptic Malignant Syndrome: Case Reports and Diagnostic Challenges. Journal of Psychoactive Drugs 54:3, pages 284-293.
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Micheal Kiyingi, Felix Bongomin, Mark Kizito & Mark Kaddumukasa. (2020) Neuroleptic Malignant Syndrome: Early Diagnosis Saves Lives in Low-Resource Settings. International Medical Case Reports Journal 13, pages 359-362.
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Articles from other publishers (58)

A. Contreras Chicote, E. Díaz, J. García Dominguez & F. Grandas. (2023) Neuroleptic malignant syndrome induced by aripiprazole depot. Neurología (English Edition).
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Muhammad U Rohail, Ayub Khan, Rhani M Pflaum, Mitul Patel & Melissa A Moody. (2023) An Atypical Case of Neuroleptic Malignant Syndrome Associated With Ciprofloxacin and Quetiapine. Cureus.
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Maxwell Miller, Alisa Zezetko & Ritvij Satodiya. (2023) Development of Atypical Neuroleptic Malignant Syndrome After Treatment of Cocaine Intoxication: A Case Report and Literature Review. Cureus.
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Bee Zhen NgSapini Yacob. (2021) Neuroleptic Malignant Syndrome in a Patient with Lithium-induced Nephrogenic Diabetes Insipidus: A Case Report. Indian Journal of Psychological Medicine 45:1, pages 91-92.
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Yan Lin, Lin Ma, Nan Zhang, Ruihua Li & Wenjing Jiang. (2022) Neuroleptic malignant-like syndrome associated multiple system atrophy: report on three cases. BMC Neurology 22:1.
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Huachang Zhao, Sijia Lu, Xiaoyan Li, Panyun Huang, Hongming Wang & Fengmei Lu. (2022) Multidisciplinary collaboration in diagnosis and treatment of neuroleptic malignant syndrome complicated with pneumonia: report of three cases. Diagnostic Pathology 17:1.
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Ramadhan ORUCH, Mohammed A. HUNEIF, Ian F. PRYME, Ole B. FASMER & Anders LUND. (2022) Drug treatment of insomnia: impact of zopiclone. Gazzetta Medica Italiana Archivio per le Scienze Mediche 181:7-8.
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J. Hillaert & P. Sienaert. (2022) Het maligne neurolepticasyndroom kan zich presenteren zonder koorts. Tijdschrift voor Geneeskunde.
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Chee Keong Chang, Alvin Oliver Payus, Malehah Mohd Noh, Meryl Grace Lansing, Doreen Sumpat, Sooth Jiun Andrea Lu & Boon Teong Yew. (2022) Neuroleptic malignant syndrome secondary to olanzapine, a presentation with severe acute kidney injury requiring hemodialysis: a case report. Journal of Medical Case Reports 16:1.
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Can SEZER & Fatih Cemal TEKİN. (2022) Persistent High Fever After Metchloropramide Treatment; Neuroleptic Malignant Syndrome. Journal of Emergency Medicine Case Reports.
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Michael Horseman, Ladan Panahi, George Udeani, Andrew S Tenpas, Rene Verduzco Jr.Pooja H Patel, Daniela Z Bazan, Andrea Mora, Nephy Samuel, Anne-Cecile Mingle, Lisa R Leon, Joseph Varon & Salim Surani. (2022) Drug-Induced Hyperthermia Review. Cureus.
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A. Contreras Chicote, E. Díaz, J. García Dominguez & F. Grandas. (2022) Síndrome neuroléptico maligno por aripiprazol depot. Neurología.
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A. Savvidou, E. Jennions, S. Wikström, M. Olsson-Engman, K. Sofou & N. Darin. (2022) Drug-induced hyperthermia with rhabdomyolysis in CLN3 disease. European Journal of Paediatric Neurology 39, pages 74-78.
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Tanya Paul, Alvina Karam, Trissa Paul, Hanyou Loh & Gerardo F Ferrer. (2022) A Case Report on Neuroleptic Malignant Syndrome (NMS): How to Approach an Early Diagnosis. Cureus.
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Haruka Takenouchi, Takatoshi Anno, Yukiko Kimura, Fumiko Kawasaki, Ryo Shirai, Hideaki Kaneto, Katsumi Kurokawa & Koichi Tomoda. (2022) Case Report: A Patient With Neuroleptic Malignant Syndrome, Water Intoxication and Hyponatremia Associated With Severe Cerebral Edema and Coma. Frontiers in Endocrinology 13.
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Hannah M. Ficarino, Michael Z. Caposole, S. Noelle Davis, Mackenzie N. Krebsbach, Emily F. McGowin, Kaitlin M. Alexander, Christopher M. Kinnard & Jon D. Simmons. (2020) Neuroleptic Malignant Syndrome: A Potential Etiology of Multisystem Organ Failure in a Burn Patient. The American Surgeon 88:3, pages 519-520.
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Ryou Izumiya, Yasuhiko Fujita & Teruyoshi Amagai. (2022) A case of influenza-associated invasive aspergillosis with cerebral hemorrhage due to infectious vasculopathy. Radiology Case Reports 17:2, pages 326-331.
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Sandeep Grover, Siddharth Sarkar & Ajit Avasthi. (2022) Clinical practice guidelines for management of medical emergencies associated with psychotropic medications. Indian Journal of Psychiatry 64:8, pages 236.
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Janice L. Forster. 2022. Management of Prader-Willi Syndrome. Management of Prader-Willi Syndrome 427 465 .
Soumaya Touzani, Mohammed Hamdouni, Nawfal Houari, Youssef Yaakoubi Khbiza, Abderrahim Elbouazzaoui, Brahim Boukatta & Nabil Kanjaa. (2021) Neuroleptic malignant syndrome cases in a Moroccan intensive care unit: a retrospective analysis and literature review. Journal of Neurocritical Care 14:2, pages 88-97.
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Stefano Berloffa, Claudia Dosi, Benedetta Tascini, Beatrice Fossati, Ilaria Lupetti & Gabriele Masi. (2021) Neuroleptic Malignant Syndrome in Children with Autism Spectrum Disorder (ASD): A Case Report and Brief Review of Recent Literature. Children 8:12, pages 1201.
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Ramadhan ORUCH, Ian F. PRYME, Ole B. FASMER & Anders LUND. (2021) Ketamine: use in psychiatry, its pharmacology and treatment following intoxication. Minerva Psychiatry 62:3.
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Guangcai Yu, Siqi Cui, Tianzi Jian, Cece Sun, Longke Shi, Yaqian Li, Baotian Kan & Xiangdong Jian. (2021) Gluteal muscle damage and rhabdomyolysis after olanzapine poisoning: a case report. Journal of International Medical Research 49:10, pages 030006052110477.
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Daniel Guinart, Fuminari Misawa, Jose M. Rubio, Justin Pereira, Renato Filippis, Chiara Gastaldon, John M. Kane & Christoph U. Correll. (2021) A systematic review and pooled, patient‐level analysis of predictors of mortality in neuroleptic malignant syndrome. Acta Psychiatrica Scandinavica 144:4, pages 329-341.
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Bernadette Wimmer, Dagmar Steffling, Zacharias Kohl & Felix Schlachetzki. (2021) Notfälle bei Bewegungsstörungen. Der Notarzt 37:05, pages 258-260.
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Kosuke Nakashima, Jun Maki, Keita Takahashi, Kazuhiro Shirozu, Yuji Shono, Kentaro Tokuda, Tomohiko Akahoshi & Ken Yamaura. (2021) A case of malignant catatonia successfully diagnosed and treated with intravenous lorazepamロラゼパム静注が診断と治療に有効だった悪性カタトニアの1症例. Journal of the Japanese Society of Intensive Care Medicine 28:5, pages 450-453.
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So-Yeon Yun, Hyun Ji Kim, Hyo Jin Park, Seong Kyu Yang, Byeongcheon Lee, Moon-Ku Han & Han-Gil Jeong. (2021) Neuroleptic Malignant Syndrome Applied with Targeted Temperature Management. Journal of the Korean Neurological Association 39:3, pages 192-196.
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Lara Prisco, Aarti Sarwal, Mario Ganau & Francesca Rubulotta. (2021) Toxicology of Psychoactive Substances. Critical Care Clinics 37:3, pages 517-541.
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Saral Desai, Tinu Hirachan, Anca Toma & Adela Gerolemou. (2021) Malignant Catatonia Versus Neuroleptic Malignant Syndrome. Cureus.
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Ka Loong Kelvin Au, Shannon Chiu & Irene A Malaty. (2021) Rhabdomyolysis secondary to severe tic fits. BMJ Case Reports 14:3, pages e239874.
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Ho-Man Yeung, Sarah Schmitz, Nino Kvantaliani & Christina Martin. (2021) Development of Neuroleptic Malignant Syndrome in a Patient with Lewy Body Dementia after Intramuscular Administration of Paliperidone. Case Reports in Neurological Medicine 2021, pages 1-4.
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Anna Maria Szota, Izabela Radajewska, Przemysław Grudzka & Aleksander Araszkiewicz. (2020) Lamotrigine, quetiapine and aripiprazole-induced neuroleptic malignant syndrome in a patient with renal failure caused by lithium: a case report. BMC Psychiatry 20:1.
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