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Neuropsychiatric Disease and Treatment Volume 14, 2018 - Issue
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Original Research

Comparative efficacy and safety of Crocus sativus L. for treating mild to moderate major depressive disorder in adults: a meta-analysis of randomized controlled trials

Xiangying Yang1 The First Branch, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
,
Xiaolu Chen1 The First Branch, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
,
Yixiao Fu2 Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
,
Qinghua Luo2 Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
,
Lian Du2 Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
,
Haitang Qiu2 Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
,
Tian Qiu2 Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
,
Li Zhang1 The First Branch, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China
&
Huaqing Meng2 Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1297-1305 | Published online: 21 May 2018

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Mojtaba Khaksarian, Masoud Behzadifar, Meysam Behzadifar, Maryam Alipour, Firouzeh Jahanpanah, Tania Simona Re, Fabio Firenzuoli, Riccardo Zerbetto & Nicola Luigi Bragazzi. (2019) The efficacy of Crocus sativus (Saffron) versus placebo and Fluoxetine in treating depression: a systematic review and meta-analysis. Psychology Research and Behavior Management 12, pages 297-305.
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Articles from other publishers (15)

Aijinxiu Ma, Fengmao Zou, Ruowen Zhang & Xu Zhao. (2022) The effects and underlying mechanisms of medicine and food homologous flowers on the prevention and treatment of related diseases. Journal of Food Biochemistry 46:12.
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Inés Moragrega & José Luis Ríos. (2021) Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials. Planta Medica 88:12, pages 1092-1110.
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M. Scuto, S. Modafferi, F. Rampulla, V. Zimbone, M. Tomasello, S. Spano’, M.L. Ontario, A. Palmeri, A. Trovato Salinaro, R. Siracusa, R. Di Paola, S. Cuzzocrea, E.J. Calabrese, U. Wenzel & V. Calabrese. (2022) Redox modulation of stress resilience by Crocus sativus L. for potential neuroprotective and anti-neuroinflammatory applications in brain disorders: From molecular basis to therapy. Mechanisms of Ageing and Development 205, pages 111686.
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Vali Musazadeh, Meysam Zarezadeh, Amir Hossein Faghfouri, Majid Keramati, Zohreh Ghoreishi & Alireza Farnam. (2022) Saffron, as an adjunct therapy, contributes to relieve depression symptoms: An umbrella meta-analysis. Pharmacological Research 175, pages 105963.
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Jean M. Bokelmann. 2022. Medicinal Herbs in Primary Care. Medicinal Herbs in Primary Care 545 567 .
Rahma Zouagui & Laila Sbabou. 2022. The Saffron Genome. The Saffron Genome 253 272 .
Dezső Csupor, Barbara Tóth, Javad Mottaghipisheh, Andrea Zangara & Emad A.S. Al-Dujaili. 2021. Nutraceuticals in Brain Health and Beyond. Nutraceuticals in Brain Health and Beyond 213 226 .
Vladimir Trkulja & Hrvoje Barić. 2021. Major Depressive Disorder. Major Depressive Disorder 375 427 .
Keith Singletary. (2020) Saffron. Nutrition Today 55:6, pages 294-303.
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Lili Dai, Lingyan Chen & Wenjing Wang. (2020) Safety and Efficacy of Saffron (Crocus sativus L.) for Treating Mild to Moderate Depression. Journal of Nervous & Mental Disease 208:4, pages 269-276.
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Amir Ghaderi, Omid Asbaghi, Željko Reiner, Fariba Kolahdooz, Elaheh Amirani, Hamed Mirzaei, Hamid Reza Banafshe, Parisa Maleki Dana & Zatollah Asemi. (2020) The effects of saffron (Crocus sativus L.) on mental health parameters and C-reactive protein: A meta-analysis of randomized clinical trials. Complementary Therapies in Medicine 48, pages 102250.
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Soghra Mehri, Bibi-Marjan Razavi & Hossein Hosseinzadeh. 2020. Saffron. Saffron 517 530 .
Mohammad Ahmadpanah, Fatemeh Ramezanshams, Ali Ghaleiha, Shahin Akhondzadeh, Dena Sadeghi Bahmani & Serge Brand. (2019) Crocus Sativus L. (saffron) versus sertraline on symptoms of depression among older people with major depressive disorders–a double-blind, randomized intervention study. Psychiatry Research 282, pages 112613.
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Elias Begas, Maria Bounitsi, Thomas Kilindris, Evangelos Kouvaras, Konstantinos Makaritsis, Demetrios Kouretas & Eftihia K. Asprodini. (2019) Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food and Chemical Toxicology 130, pages 32-43.
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Adrian L. Lopresti. (2019) It is time to investigate integrative approaches to enhance treatment outcomes for depression?. Medical Hypotheses 126, pages 82-94.
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