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Neuropsychiatric Disease and Treatment Volume 14, 2018 - Issue
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Review

Valium without dependence? Individual GABAA receptor subtype contribution toward benzodiazepine addiction, tolerance, and therapeutic effects

Tianze Cheng1 Pitzer College, Claremont, CA, USACorrespondence[email protected]
,
Dominique Marie Wallace2 Portland State University, Portland, OR, USA
,
Benjamin Ponteri1 Pitzer College, Claremont, CA, USA
&
Mahir Tuli3 University of British Columbia, Vancouver, BC, Canada
Pages 1351-1361 | Published online: 23 May 2018

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Thomas Hillemacher & Helge Frieling. (2019) Pharmacotherapeutic options for co-morbid depression and alcohol dependence. Expert Opinion on Pharmacotherapy 20:5, pages 547-569.
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Mark K. Greenwald, Tabitha E. H. Moses, Leslie H. Lundahl & Timothy A. Roehrs. (2023) Anhedonia modulates benzodiazepine and opioid demand among persons in treatment for opioid use disorder. Frontiers in Psychiatry 14.
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Andreas Capiau, Liesbeth Huys, Eveline van Poelgeest, Nathalie van der Velde, Mirko Petrovic & Annemie Somers. (2022) Therapeutic dilemmas with benzodiazepines and Z-drugs: insomnia and anxiety disorders versus increased fall risk: a clinical review. European Geriatric Medicine.
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Rachel Gurrell, Philip Iredale, Alexis Evrard, Venceslas Duveau, Céline Ruggiero & Corinne Roucard. (2022) Pronounced antiseizure activity of the subtype‐selective GABA A positive allosteric modulator darigabat in a mouse model of drug‐resistant focal epilepsy . CNS Neuroscience & Therapeutics 28:11, pages 1875-1882.
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Hélder Fernandes, Vânia Batalha, Ellen Braksator, Simon Hebeisen, Maria João Bonifácio, Maria Augusta Vieira-Coelho & Patrício Soares-da-Silva. (2022) Voltage-clamp evidence of GABAA receptor subunit-specific effects: pharmacodynamic fingerprint of chlornordiazepam, the major active metabolite of mexazolam, as compared to alprazolam, bromazepam, and zolpidem. Pharmacological Reports 74:5, pages 956-968.
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Jeffrey M. Witkin, Arnold Lippa, Jodi L. Smith, James M. Cook & Rok Cerne. (2022) Can GABAkines quiet the noise? The GABAA receptor neurobiology and pharmacology of tinnitus. Biochemical Pharmacology 201, pages 115067.
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Christina M. Boada, Scott N. Grossman, Caitlin L. Grzeskowiak, Sonya Dumanis & Jacqueline A. French. (2021) Proceedings of the 2020 Epilepsy Foundation Pipeline Conference: Emerging Drugs and Devices. Epilepsy & Behavior 125, pages 108364.
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Mélinée Chapoutot, Laure Peter-Derex, Hélène Bastuji, Wendy Leslie, Benjamin Schoendorff, Raphael Heinzer, Francesca Siclari, Alain Nicolas, Patrick Lemoine, Susan Higgins, Alexia Bourgeois, Guillaume T. Vallet, Royce Anders, Marc Ounnoughene, Jessica Spencer, Francesca Meloni & Benjamin Putois. (2021) Cognitive Behavioral Therapy and Acceptance and Commitment Therapy for the Discontinuation of Long-Term Benzodiazepine Use in Insomnia and Anxiety Disorders. International Journal of Environmental Research and Public Health 18:19, pages 10222.
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Devina Sharma, Aparna Banerjee Dixit, Soumil Dey, Manjari Tripathi, Ramesh Doddamani, M.C. Sharma, Sanjeev Lalwani, Hitesh Kumar Gurjar, P. Sarat Chandra & Jyotirmoy Banerjee. (2021) Increased levels of α4-containing GABAA receptors in focal cortical dysplasia: A possible cause of benzodiazepine resistance. Neurochemistry International 148, pages 105084.
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Ilandarage Menu Neelaka Molagoda, Mirissa Hewage Dumindu Kavinda, Hyung Won Ryu, Yung Hyun Choi, Jin-Woo Jeong, Sanghyuck Kang & Gi-Young Kim. (2021) Gamma-Aminobutyric Acid (GABA) Inhibits α-Melanocyte-Stimulating Hormone-Induced Melanogenesis through GABAA and GABAB Receptors. International Journal of Molecular Sciences 22:15, pages 8257.
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Iman Imtiyaz Ahmed Juvale & Ahmad Tarmizi Che Has. (2020) Possible interplay between the theories of pharmacoresistant epilepsy. European Journal of Neuroscience 53:6, pages 1998-2026.
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Strahinja Stevanovic, Djordje S. Marjanović, Sasa M. Trailović, Nemanja Zdravković, Andrej Perdih & Katarina Nikolic. (2021) Potential modulating effect of the Ascaris suum nicotinic acetylcholine receptor (nAChR) by compounds GSK575594A, diazepam and flumazenil discovered by structure-based virtual screening approach. Molecular and Biochemical Parasitology 242, pages 111350.
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David Castellano, Ryan David Shepard & Wei Lu. (2021) Looking for Novelty in an “Old” Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology. Frontiers in Neuroscience 14.
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Huabin Lei, Wei Wang, Yinan Cao, Yaru Ma & Xusheng Xue. (2021) Efficacy and safety evaluation of bright light therapy in patients with post-stroke insomnia. Medicine 100:50, pages e27937.
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Latifeh Navidpour, Shabnam Shabani, Alireza Heidari, Manouchehr Bashiri, Azadeh Ebrahim-Habibi, Soraya Shahhosseini, Hamed Shafaroodi, Sayyed Abbas Tabatabai & Mahsa Toolabi. (2021) 5-[Aryloxypyridyl (or nitrophenyl)]-4H-1,2,4-triazoles as novel flexible benzodiazepine analogues: Synthesis, receptor binding affinity and lipophilicity-dependent anti-seizure onset of action. Bioorganic Chemistry 106, pages 104504.
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Angela Federico, Fabio Lugoboni, Elisa Mantovani, Alice Martini, Laura Morbioli, Rebecca Casari, Marco Faccini & Stefano Tamburin. (2020) Detoxification Improves Multidomain Cognitive Dysfunction in High-Dose Benzodiazepine Abusers. Frontiers in Neuroscience 14.
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Samuele Maramai, Mohamed Benchekroun, Simon E. WardJohn R. Atack. (2019) Subtype Selective γ-Aminobutyric Acid Type A Receptor (GABA A R) Modulators Acting at the Benzodiazepine Binding Site: An Update . Journal of Medicinal Chemistry 63:7, pages 3425-3446.
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Jocelien D. A. Olivier & Berend Olivier. 2020. Anxiety Disorders. Anxiety Disorders 121 140 .
Simone B. Sartori & Nicolas Singewald. (2019) Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders. Pharmacology & Therapeutics 204, pages 107402.
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Denise Gleeson. (2019) Benzodiazepines: Dependence and addiction in general practice. InnovAiT: Education and inspiration for general practice 12:11, pages 656-663.
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Marco Faccini, Stefano Tamburin, Rebecca Casari, Laura Morbioli & Fabio Lugoboni. (2019) High-dose lormetazepam dependence: strange case of Dr. Jekyll and Mr. Hyde. Internal and Emergency Medicine 14:8, pages 1271-1278.
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