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Neuropsychiatric Disease and Treatment Volume 14, 2018 - Issue
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Original Research

Dexmedetomidine attenuates the propofol-induced long-term neurotoxicity in the developing brain of rats by enhancing the PI3K/Akt signaling pathway

Yong Xiao1 Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China, [email protected]
,
Lifang Zhou2 Department of Anesthesiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China
,
Youbing Tu1 Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China, [email protected]
,
Yuantao Li3 Department of Anesthesiology, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, People’s Republic of China
,
Yubing Liang4 Department of Anesthesiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, People’s Republic of China
,
Xu Zhang1 Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China, [email protected]
,
Jing Lv1 Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China, [email protected]
,
Yu Zhong1 Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China, [email protected]
&
Yubo Xie1 Department of Anesthesiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, People’s Republic of China, [email protected]Correspondence[email protected]
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Pages 2191-2206 | Published online: 28 Aug 2018

Citations (11)

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Ega Qeva, Camilla Sollazzo & Federico Bilotta. (2022) Insulin signaling in the central nervous system, a possible pathophysiological mechanism of anesthesia-induced delayed neurocognitive recovery/postoperative neurocognitive disorder: a narrative review. Expert Review of Neurotherapeutics 22:10, pages 839-847.
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Youbing Tu, Yubing Liang, Yong Xiao, Jing Lv, Ruicong Guan, Fei Xiao, Yubo Xie & Qiang Xiao. (2019) Dexmedetomidine attenuates the neurotoxicity of propofol toward primary hippocampal neurons in vitro via Erk1/2/CREB/BDNF signaling pathways. Drug Design, Development and Therapy 13, pages 695-706.
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Articles from other publishers (9)

Jing Zhang & Yu Li. (2023) Propofol-Induced Developmental Neurotoxicity: From Mechanisms to Therapeutic Strategies. ACS Chemical Neuroscience 14:6, pages 1017-1032.
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Jing Chen, Fei Xiao, Lifei Chen, Zhan Zhou, Yi Wei, Yu Zhong, Li Li & Yubo Xie. (2023) Role of ferroptosis in hypoxic preconditioning to reduce propofol neurotoxicity. Frontiers in Pharmacology 14.
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Zong Chen, Yong Ding, Ying Zeng, Xue-Ping Zhang & Jian-Yan Chen. (2022) Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway. BMC Pharmacology and Toxicology 23:1.
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Nerea Jimenez-Tellez, Fahad Iqbal, Marcus Pehar, Alberto Casas-Ortiz, Tiffany Rice & Naweed I. Syed. (2021) Dexmedetomidine does not compromise neuronal viability, synaptic connectivity, learning and memory in a rodent model. Scientific Reports 11:1.
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Yangliang Yang, Jing Yi, Mengzhi Pan, Baoji Hu & Hongwei Duan. (2021) Edaravone alleviated propofol‐induced neural injury in developing rats by BDNF/TrkB pathway. Journal of Cellular and Molecular Medicine 25:11, pages 4974-4987.
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Hao Fang, Zhen Yang & Liu Yang. (2021) Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway. NeuroReport 32:7, pages 577-582.
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Wenchong Sun, Jian Wang, Dasheng Cai & Ling Pei. (2020) Neuroprotection of the Developing Brain by Dexmedetomidine Is Mediated by Attenuating Single Propofol-induced Hippocampal Apoptosis and Synaptic Plasticity Deficits. Experimental Neurobiology 29:5, pages 356-375.
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Na Xing, Fei Xing, Yanna Li, Pingle Li, Jianwen Zhang, Dongmei Wang, Wei Zhang & Jianjun Yang. (2020) Dexmedetomidine improves propofol-induced neuronal injury in rat hippocampus with the involvement of miR-34a and the PI3K/Akt signaling pathway. Life Sciences 247, pages 117359.
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Toru Goyagi. (2019) Dexmedetomidine reduced sevoflurane‐induced neurodegeneration and long‐term memory deficits in neonatal rats. International Journal of Developmental Neuroscience 75:1, pages 19-26.
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