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Neuropsychiatric Disease and Treatment Volume 15, 2019 - Issue
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Review

An update on the anxiolytic and neuroprotective properties of etifoxine: from brain GABA modulation to a whole-body mode of action

Philippe Nuss1 Department of Adult Psychiatry and Medical Psychology, Sorbonne University, Saint-Antoine Hospital, Paris, France;2 Inserm UMR_S938, Saint-Antoine Research Centre, Sorbonne University, Paris, FranceCorrespondence[email protected]
,
Florian Ferreri1 Department of Adult Psychiatry and Medical Psychology, Sorbonne University, Saint-Antoine Hospital, Paris, France
&
Michel Bourin3 Department of Neurobiology of Anxiety and Depression, Faculty of Medicine, Nantes University, Nantes, France
Pages 1781-1795 | Published online: 03 Jul 2019

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Genoveva Uzunova, Stefano Pallanti & Eric Hollander. (2021) Presentation and management of anxiety in individuals with acute symptomatic or asymptomatic COVID-19 infection, and in the post-COVID-19 recovery phase. International Journal of Psychiatry in Clinical Practice 25:2, pages 115-131.
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Articles from other publishers (15)

Elisa Angeloni, Lorenzo Germelli, Laura Marchetti, Eleonora Da Pozzo, Chiara Tremolanti, Christian H. Wetzel, Emma Baglini, Sabrina Taliani, Federico Da Settimo, Claudia Martini & Barbara Costa. (2023) The human microglial surveillant phenotype is preserved by de novo neurosteroidogenesis through the control of cholesterol homeostasis: Crucial role of 18 kDa Translocator Protein. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1869:6, pages 166751.
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Donghyeon Lee & Ryo Shintani. (2023) Palladium-catalyzed synthesis of 4-sila-4 H -benzo[ d ][1,3]oxazines by intramolecular Hiyama coupling . Chemical Science 14:15, pages 4114-4119.
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A. V. Vasileva. (2023) Post-traumatic stress disorder – from traumatic neurosis to ICD-11: features of diagnosis and selection of therapy. Meditsinskiy sovet = Medical Council:3, pages 94-108.
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Akbar Hajizadeh Moghaddam, Mohammad Amin Mashayekhpour & Mohaddeseh Abouhosseini Tabari. (2022) Anxiolytic-like effects of citral in the mouse elevated plus maze: involvement of GABAergic and serotonergic transmissions. Naunyn-Schmiedeberg's Archives of Pharmacology 396:2, pages 301-309.
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D.S. Petelin, S.P. Bairamova, R.V. Akhapkin, N.V. Kudryashov, O.Yu. Sorokina, S.A. Semin & B.A. Volel. (2023) A role of neurosteroids in the pathogenesis of psychiatric disorders. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 123:4, pages 31.
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K. Genaro, R.F. Yoshimura, B.P. Doan, T.B. Johnstone, D.J. Hogenkamp & K.W. Gee. (2022) Allosteric modulators of the δ GABAA receptor subtype demonstrate a therapeutic effect in morphine-antinociceptive tolerance and withdrawal in mice. Neuropharmacology 219, pages 109221.
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Heng Shao, Quan Gan, Zhuangfei Chen, Shasha Zhu & Yanqing Zhu. (2022) Analysis of the Underlying Mechanism of the Jiu Wei Zhen Xin Formula for Treating Generalized Anxiety Disorder Based on Network Pharmacology of Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-12.
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Petra Bloms-Funke, Michael Schumacher, Song Liu, Diya Su, Jing Li, Philippe Liere, Rainer Rupprecht, Caroline Nothdurfter, Gregor Bahrenberg, Thomas Christoph, Christopher Habermann, Christa Kneip, Wolfgang Schröder, Thomas M. Tzschentke & Derek Saunders. (2022) A novel dual mode-of-action anti-hyperalgesic compound in rats which is neuroprotective and promotes neuroregeneration. European Journal of Pharmacology 923, pages 174935.
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Joshua Wang & Kate Beecher. (2021) TSPO: an emerging role in appetite for a therapeutically promising biomarker. Open Biology 11:8.
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Esmé Jansen van Vuren, Stephan F. Steyn, Christiaan B. Brink, Marisa Möller, Francois P. Viljoen & Brian H. Harvey. (2021) The neuropsychiatric manifestations of COVID-19: Interactions with psychiatric illness and pharmacological treatment. Biomedicine & Pharmacotherapy 135, pages 111200.
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Lisa-Marie Bahr, Franziska Maurer, Johannes Weigl, Kevin Weber, Doris Melchner, Anett Dörfelt, Theresa F. Wechsler, Olivia Bauer, Jörg Reinders, Vladimir M. Milenkovic, Christian H. Wetzel, Thomas C. Wetter, Rainer Rupprecht, Andreas Mühlberger & Caroline Nothdurfter. (2021) Dissociation of endocrine responses to the Trier Social Stress Test in Virtual Reality (VR-TSST) by the benzodiazepine alprazolam and the translocator protein 18 kDa (TSPO) ligand etifoxine. Psychoneuroendocrinology 124, pages 105100.
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Michel Bourin. 2021. Psychiatry and Neuroscience Update. Psychiatry and Neuroscience Update 647 660 .
Hui Zhang, Li Ma, Wen-zhi Guo, Lin-bo Jiao, Hong-yu Zhao, Ya-qun Ma & Xue-mei Hao. (2020) TSPO ligand etifoxine attenuates LPS-induced cognitive dysfunction in mice. Brain Research Bulletin 165, pages 178-184.
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Benjamín Vicente, Sandra Saldivia, Naín Hormazabal, Claudio Bustos & Patricia Rubí. (2020) Etifoxine is non-inferior than clonazepam for reduction of anxiety symptoms in the treatment of anxiety disorders: a randomized, double blind, non-inferiority trial. Psychopharmacology 237:11, pages 3357-3367.
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Simone B. Sartori & Nicolas Singewald. (2019) Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders. Pharmacology & Therapeutics 204, pages 107402.
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