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Neuropsychiatric Disease and Treatment Volume 10, 2014 - Issue
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Review

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia

Daniel J FosterDepartment of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, USA
,
Derrick L ChoiDepartment of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, USA
,
P Jeffrey ConnDepartment of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, USA
&
Jerri M RookDepartment of Pharmacology and Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN, USACorrespondence[email protected]
Pages 183-191 | Published online: 28 Jan 2014

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Ayesha Khan, Anne Corbett & Clive Ballard. (2017) Emerging amyloid and tau targeting treatments for Alzheimer’s disease. Expert Review of Neurotherapeutics 17:7, pages 697-711.
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Ayesha Khan, Anne Corbett & Clive Ballard. (2017) Emerging treatments for Alzheimer’s disease for non-amyloid and non-tau targets. Expert Review of Neurotherapeutics 17:7, pages 683-695.
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U. Damar, R. Gersner, J. T. Johnstone, S. Schachter & A. Rotenberg. (2016) Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research. Expert Review of Neurotherapeutics 16:6, pages 671-680.
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Martin Broadstock, Clive Ballard & Anne Corbett. (2014) Latest treatment options for Alzheimer’s disease, Parkinson’s disease dementia and dementia with Lewy bodies. Expert Opinion on Pharmacotherapy 15:13, pages 1797-1810.
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Articles from other publishers (22)

Rongmei Xu, Min Wan, Xuemeng Shi, Shumin Ma, Lina Zhang, Ping Yi & Rongying Zhang. (2023) A Rab10–ACAP1–Arf6 GTPases cascade modulates M4 muscarinic acetylcholine receptor trafficking and signaling. Cellular and Molecular Life Sciences 80:4.
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Bhabotosh Barman, Akanksha Kushwaha & Mahendra Kumar Thakur. (2022) Muscarinic Acetylcholine Receptors-Mediated Activation of PKC Restores the Hippocampal Immediate Early Gene Expression and CREB Phosphorylation in Scopolamine-Induced Amnesic Mice. Molecular Neurobiology 59:9, pages 5722-5733.
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Victoria L. Fisher, Liara S. Ortiz & Albert R. PowersIIIIII. (2022) A computational lens on menopause-associated psychosis. Frontiers in Psychiatry 13.
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Jakub Cikowski, Calista Holt, Bright Arthur, Mackenzie Smith, Sonia Gonzalez, Craig W. Lindsley, Colleen M. Niswender & Rocco G. Gogliotti. (2022) Optimized Administration of the M 4 PAM VU0467154 Demonstrates Broad Efficacy, but Limited Effective Concentrations in Mecp2 +/ – Mice . ACS Chemical Neuroscience 13:13, pages 1891-1901.
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Orkid Coskuner-Weber, Ozan Mirzanli & Vladimir N. Uversky. (2022) Intrinsically disordered proteins and proteins with intrinsically disordered regions in neurodegenerative diseases. Biophysical Reviews 14:3, pages 679-707.
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Chad R. Johnson, Brian D. Kangas, Emily M. Jutkiewicz, Jack Bergman & Andrew Coop. (2022) Drug Design Targeting the Muscarinic Receptors and the Implications in Central Nervous System Disorders. Biomedicines 10:2, pages 398.
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Patrik Oleksak, Michal Novotny, Jiri Patocka, Eugenie Nepovimova, Jakub Hort, Jan Pavlik, Blanka Klimova, Martin Valis & Kamil Kuca. (2021) Neuropharmacology of Cevimeline and Muscarinic Drugs—Focus on Cognition and Neurodegeneration. International Journal of Molecular Sciences 22:16, pages 8908.
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Mohiminul Adib, Rashedul Islam, Monira Ahsan, Arifur Rahman, Mahmud Hossain, Md Mustafizur Rahman, Sultan M. Alshehri, Mohsin Kazi & Md Abdul Mazid. (2021) Cholinesterase inhibitory activity of tinosporide and 8-hydroxytinosporide isolated from Tinospora cordifolia: In vitro and in silico studies targeting management of Alzheimer’s disease. Saudi Journal of Biological Sciences 28:7, pages 3893-3900.
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Cassandra J. Hatzipantelis, Monica Langiu, Teresa H. Vandekolk, Tracie L. Pierce, Jess Nithianantharajah, Gregory D. Stewart & Christopher J. Langmead. (2020) Translation-Focused Approaches to GPCR Drug Discovery for Cognitive Impairments Associated with Schizophrenia. ACS Pharmacology & Translational Science 3:6, pages 1042-1062.
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Arpita Konar, Richa Gupta, Rajendra K. Shukla, Bryan Maloney, Vinay K. Khanna, Renu Wadhwa, Debomoy K. Lahiri & Mahendra K. Thakur. (2019) M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera. Scientific Reports 9:1.
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Catherine A. Thorn, Joshua Moon, Clinton A. Bourbonais, John Harms, Jeremy R. Edgerton, Eda Stark, Stefanus J. Steyn, Christopher R. Butter, John T. Lazzaro, Rebecca E. O’Connor & Michael Popiolek. (2018) Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline. ACS Chemical Neuroscience 10:3, pages 1753-1764.
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Santiago G. Lago & Sabine Bahn. (2018) Clinical Trials and Therapeutic Rationale for Drug Repurposing in Schizophrenia. ACS Chemical Neuroscience 10:1, pages 58-78.
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Arpita Konar, Ashish Kumar, Bryan Maloney, Debomoy K. Lahiri & Mahendra K. Thakur. (2018) A serine protease KLK8 emerges as a regulator of regulators in memory: Microtubule protein dependent neuronal morphology and PKA-CREB signaling. Scientific Reports 8:1.
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Anna Popelíková, Štěpán Bahník, Veronika Lobellová, Jan Svoboda & Aleš Stuchlík. (2018) Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat. Psychopharmacology 235:7, pages 2013-2025.
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Fabio Del Bello, Alessandro Bonifazi, Gianfabio Giorgioni, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura, Riccardo Petrelli, Alessandro Piergentili, Stefano Fontana, Valerio Mammoli, Hideaki Yano, Rosanna Matucci, Giulio Vistoli & Wilma Quaglia. (2018) 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D 4 Receptor . Journal of Medicinal Chemistry 61:8, pages 3712-3725.
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Qingwei Ruan, Zhuowei Yu, Weibin Zhang, Jian Ruan, Chunhui Liu & Ruxin Zhang. (2018) Cholinergic Hypofunction in Presbycusis-Related Tinnitus With Cognitive Function Impairment: Emerging Hypotheses. Frontiers in Aging Neuroscience 10.
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Jan Svoboda, Anna Popelikova & Ales Stuchlik. (2017) Drugs Interfering with Muscarinic Acetylcholine Receptors and Their Effects on Place Navigation. Frontiers in Psychiatry 8.
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Jennifer E. Davoren, Michelle Garnsey, Betty Pettersen, Michael A. Brodney, Jeremy R. Edgerton, Jean-Philippe Fortin, Sarah Grimwood, Anthony R. Harris, Stephen Jenkinson, Terry Kenakin, John T. Lazzaro, Che-Wah Lee, Susan M. Lotarski, Lisa Nottebaum, Steven V. O’Neil, Michael Popiolek, Simeon Ramsey, Stefanus J. Steyn, Catherine A. Thorn, Lei Zhang & Damien Webb. (2017) Design and Synthesis of γ- and δ-Lactam M 1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M 1 -Selective PAM with Weak Agonist Activity . Journal of Medicinal Chemistry 60:15, pages 6649-6663.
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Michael Popiolek, David P. Nguyen, Veronica Reinhart, Jeremy R. Edgerton, John Harms, Susan M. Lotarski, Stefanus J. Steyn, Jennifer E. Davoren & Sarah Grimwood. (2016) Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M 1 Receptor Activation . Biochemistry 55:51, pages 7073-7085.
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Jennifer E. Davoren, Che-Wah Lee, Michelle Garnsey, Michael A. Brodney, Jason Cordes, Keith Dlugolenski, Jeremy R. Edgerton, Anthony R. Harris, Christopher J. Helal, Stephen Jenkinson, Gregory W. Kauffman, Terrence P. Kenakin, John T. Lazzaro, Susan M. Lotarski, Yuxia Mao, Deane M. Nason, Carrie Northcott, Lisa Nottebaum, Steven V. O’Neil, Betty Pettersen, Michael Popiolek, Veronica Reinhart, Romelia Salomon-Ferrer, Stefanus J. Steyn, Damien Webb, Lei Zhang & Sarah Grimwood. (2016) Discovery of the Potent and Selective M1 PAM-Agonist N -[(3 R ,4 S )-3-Hydroxytetrahydro-2 H -pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects . Journal of Medicinal Chemistry 59:13, pages 6313-6328.
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Megan Elizabeth Rich & Heather Kingsley Caldwell. (2015) A Role for Oxytocin in the Etiology and Treatment of Schizophrenia. Frontiers in Endocrinology 6.
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Cindy Lustig & Martin Sarter. 2016. Translational Neuropsychopharmacology. Translational Neuropsychopharmacology 327 362 .

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