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Neuropsychiatric Disease and Treatment Volume 10, 2014 - Issue
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Original Research

Tipepidine in children with attention deficit/hyperactivity disorder: a 4-week, open-label, preliminary study

Tsuyoshi Sasaki1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan;2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, JapanCorrespondence[email protected]
,
Kenji Hashimoto3 Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
,
Masumi Tachibana1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan
,
Tsutomu Kurata1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan
,
Keiko Okawada1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan
,
Maki Ishikawa1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan
,
Hiroshi Kimura2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Hideki Komatsu2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Masatomo Ishikawa2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Tadashi Hasegawa2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Akihiro Shiina1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan
,
Tasuku Hashimoto2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Nobuhisa Kanahara3 Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
,
Tetsuya Shiraishi2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
&
Masaomi Iyo1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan;2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan;3 Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
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Pages 147-151 | Published online: 24 Jan 2014

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Shun Hayashi, Hiroko Kawaguchi, Takao Watanabe, Izuru Miyawaki, Tatsuki Fukami & Miki Nakajima. (2023) Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver. Xenobiotica 53:4, pages 241-247.
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Ann C. Childress, Nathalie Beltran, Carl Supnet & Margaret D. Weiss. (2021) Reviewing the role of emerging therapies in the ADHD armamentarium. Expert Opinion on Emerging Drugs 26:1, pages 1-16.
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Marco Pozzi, Silvana Bertella, Erika Gatti, Gabriëlla G. A. M. Peeters, Carla Carnovale, Stefania Zambrano & Maria Nobile. (2020) Emerging drugs for the treatment of attention-deficit hyperactivity disorder (ADHD). Expert Opinion on Emerging Drugs 25:4, pages 395-407.
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Ann Childress & Chau Tran. (2016) Current Investigational Drugs for the Treatment of Attention-Deficit/Hyperactivity Disorder. Expert Opinion on Investigational Drugs 25:4, pages 463-474.
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Tsuyoshi Sasaki, Kenji Hashimoto, Masumi Tachibana, Tsutomu Kurata, Hiroshi Kimura, Hideki Komatsu, Masatomo Ishikawa, Tadashi Hasegawa, Akihiro Shiina, Tasuku Hashimoto, Nobuhisa Kanahara, Tetsuya Shiraishi & Masaomi Iyo. (2014) Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study. Neuropsychiatric Disease and Treatment 10, pages 719-722.
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Wei Zhao, Yane Yin, Fuxiang Qin, Xinyu Lin & Liming Zhang. (2021) Effects of early intake of amino acid on the neurodevelopmental outcomes in very low birth weight infants at correct age of 20 months and school age. Irish Journal of Medical Science (1971 -) 191:1, pages 283-288.
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Yulin Zhao, Isabel Gameiro-Ros, Ian W. Glaaser & Paul A. Slesinger. (2021) Advances in Targeting GIRK Channels in Disease. Trends in Pharmacological Sciences 42:3, pages 203-215.
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Chihiro Takase, Kentaro Shirai, Yu Matsumura, Tomohiro Watanabe, Akimitsu Watanabe, Ayaka Hirasawa-Inoue, Takeshi Mizuguchi, Naomichi Matsumoto, Kenji Sugai & Masaharu Hayashi. (2020) KCNT1-positive epilepsy of infancy with migrating focal seizures successfully treated with nonnarcotic antitussive drugs after treatment failure with quinidine: A case report. Brain and Development 42:8, pages 607-611.
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Georg C. Ziegler, Christoph Röser, Tobias Renner, Tim Hahn, Ann‐Christine Ehlis, Heike Weber, Astrid Dempfle, Susanne Walitza, Christian Jacob, Marcel Romanos, Andreas J. Fallgatter, Andreas Reif & Klaus‐Peter Lesch. (2019) KCNJ6 variants modulate reward‐related brain processes and impact executive functions in attention‐deficit/hyperactivity disorder . American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 183:5, pages 247-257.
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Sara Dehbozorghi, Sayna Bagheri, Kamyar Moradi, Kamyar Shokraee, Mohammad‐Reza Mohammadi & Shahin Akhondzadeh. (2019) Efficacy and safety of tipepidine as adjunctive therapy in children with attention‐deficit/hyperactivity disorder: Randomized, double‐blind, placebo‐controlled clinical trial. Psychiatry and Clinical Neurosciences 73:11, pages 690-696.
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Risa Miki, Ikutaro Honda, Ryota Hamasaki, Ryo Kawahara, Fumio Soeda, Tetsuya Shirasaki, Shogo Misumi & Kazuo Takahama. (2019) Effects of tipepidine on MK-801-induced cognitive impairment in mice. Brain Research 1710, pages 230-236.
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Wayland E. Noland, Matthew P. Huisenga, Ryan J. Herzig, John A. Rosenow, Hoyeon Kim, Neil J. Kroll, Andrei Nesmelov, Benjamin T. Johnson, Nathan S. Duncan, Jidapa Ratanayanon, Ruixian A. Yue, Kenny Xiong, Bee K. Ong, Diane T. Vo, Nathan D. Klein, Simon B. Lang, Jacob K. Riley, Steven P. Daniels & Kenneth J. Tritch. (2018) A Diels–Alder/Ene Cascade Leading to 5‐(Pyrrolidin‐3‐yl)thieno[3,2‐ e ]isoindoles from Ketone‐derived 2‐Vinylthiophenes and N ‐Phenylmaleimide . Journal of Heterocyclic Chemistry 55:12, pages 2698-2714.
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Michael A. Mooney, Shannon K. McWeeney, Stephen V. Faraone, Anke Hinney, Johannes Hebebrand, Joel T. Nigg & Beth Wilmot. (2016) Pathway analysis in attention deficit hyperactivity disorder: An ensemble approach. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 171:6, pages 815-826.
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Fumio Soeda, Yoshiko Fujieda, Mizue Kinoshita, Tetsuya Shirasaki & Kazuo Takahama. (2016) Centrally acting non-narcotic antitussives prevent hyperactivity in mice: Involvement of GIRK channels. Pharmacology Biochemistry and Behavior 144, pages 26-32.
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Kenji Hashimoto & Tsuyoshi Sasaki. (2014) Old drug tipepidine as new hope for children with ADHD. Australian & New Zealand Journal of Psychiatry 49:2, pages 181-182.
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Jody Mayfield, Yuri A. Blednov & R. Adron Harris. 2015. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels 279 313 .
Ian W. Glaaser & Paul A. Slesinger. 2015. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels 117 160 .

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