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Neuropsychiatric Disease and Treatment Volume 10, 2014 - Issue
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Letter

Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study

Tsuyoshi Sasaki1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan;2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, JapanCorrespondence[email protected]
,
Kenji Hashimoto3 Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
,
Masumi Tachibana1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan
,
Tsutomu Kurata1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan
,
Hiroshi Kimura2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Hideki Komatsu2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Masatomo Ishikawa2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Tadashi Hasegawa2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Akihiro Shiina1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan
,
Tasuku Hashimoto2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
,
Nobuhisa Kanahara4 Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
,
Tetsuya Shiraishi2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan
&
Masaomi Iyo1 Department of Child Psychiatry, Chiba University Hospital, Chiba, Japan;2 Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan;3 Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan;4 Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Inohana, Chiba, Japan
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Pages 719-722 | Published online: 05 May 2014

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Shun Hayashi, Hiroko Kawaguchi, Takao Watanabe, Izuru Miyawaki, Tatsuki Fukami & Miki Nakajima. (2023) Estimation of contribution of CYP2D6 to tipepidine metabolism in humans and prolongation of the half-life of tipepidine by combination use with a CYP2D6 inhibitor in chimeric mice with humanised liver. Xenobiotica 53:4, pages 241-247.
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Danko Jeremic, Irene Sanchez-Rodriguez, Lydia Jimenez-Diaz & Juan D. Navarro-Lopez. (2021) Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system. Pharmacology & Therapeutics 223, pages 107808.
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Saba Hoobehfekr, Hossein Sanjari Moghaddam, Mohammadreza Shalbafan, Maryam Ghazizadeh Hashemi, Mohammad Mehdi Pirmoradi, Amirhossein Sakenian, Amirhossein Poopak, Shayan Kashefinejad, Masoomeh Yarahmadi & Shahin Akhondzadeh. (2020) Efficacy and safety of tipepidine as adjunctive therapy in major depressive disorder: A randomized, double‐blind, placebo‐controlled clinical trial. Psychiatry and Clinical Neurosciences 75:2, pages 57-62.
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Sara Dehbozorghi, Sayna Bagheri, Kamyar Moradi, Kamyar Shokraee, Mohammad‐Reza Mohammadi & Shahin Akhondzadeh. (2019) Efficacy and safety of tipepidine as adjunctive therapy in children with attention‐deficit/hyperactivity disorder: Randomized, double‐blind, placebo‐controlled clinical trial. Psychiatry and Clinical Neurosciences 73:11, pages 690-696.
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Risa Miki, Ikutaro Honda, Ryota Hamasaki, Ryo Kawahara, Fumio Soeda, Tetsuya Shirasaki, Shogo Misumi & Kazuo Takahama. (2019) Effects of tipepidine on MK-801-induced cognitive impairment in mice. Brain Research 1710, pages 230-236.
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Wayland E. Noland, Matthew P. Huisenga, Ryan J. Herzig, John A. Rosenow, Hoyeon Kim, Neil J. Kroll, Andrei Nesmelov, Benjamin T. Johnson, Nathan S. Duncan, Jidapa Ratanayanon, Ruixian A. Yue, Kenny Xiong, Bee K. Ong, Diane T. Vo, Nathan D. Klein, Simon B. Lang, Jacob K. Riley, Steven P. Daniels & Kenneth J. Tritch. (2018) A Diels–Alder/Ene Cascade Leading to 5‐(Pyrrolidin‐3‐yl)thieno[3,2‐ e ]isoindoles from Ketone‐derived 2‐Vinylthiophenes and N ‐Phenylmaleimide . Journal of Heterocyclic Chemistry 55:12, pages 2698-2714.
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Ikutaro Honda, Kimi Araki, Sokichi Honda, Fumio Soeda, Min-Chul Shin, Shogo Misumi, Ken-ichi Yamamura & Kazuo Takahama. (2018) Deletion of GIRK2 subunit containing GIRK channels of neurons expressing dopamine transporter decrease immobility time on forced swimming in mice. Neuroscience Letters 665, pages 140-146.
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Ruben Vardanyan. 2017. Piperidine-Based Drug Discovery. Piperidine-Based Drug Discovery 127 146 .
Kazuaki Kawaura, Yukino Ogata, Sokichi Honda, Fumio Soeda, Tetsuya Shirasaki & Kazuo Takahama. (2016) Tipepidine, a non-narcotic antitussive, exerts an antidepressant-like effect in the forced swimming test in adrenocorticotropic hormone-treated rats. Behavioural Brain Research 302, pages 269-278.
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Yukihiko Shirayama, Masatoshi Suzuki, Michio Takahashi, Koichi Sato & Kenji Hashimoto. (2015) Effects of add-on tipepidine on treatment-resistant depression: an open-label pilot trial. Acta Neuropsychiatrica 28:1, pages 51-54.
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Jody Mayfield, Yuri A. Blednov & R. Adron Harris. 2015. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels 279 313 .
Ian W. Glaaser & Paul A. Slesinger. 2015. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels. Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels 117 160 .

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