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Review

Yokukan-san: a review of the evidence for use of this Kampo herbal formula in dementia and psychiatric conditions

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Pages 1727-1742 | Published online: 12 Sep 2014

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Takashi Ozaki, Yuriko Katsumata & Asuna Arai. (2017) The use of psychotropic drugs for behavioral and psychological symptoms of dementia among residents in long-term care facilities in Japan. Aging & Mental Health 21:12, pages 1248-1255.
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Stanley N. Caroff, E. Cabrina Campbell & Benjamin Carroll. (2017) Pharmacological treatment of tardive dyskinesia: recent developments. Expert Review of Neurotherapeutics 17:9, pages 871-881.
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Maria Baczewska, Milena Królikowska, Martyna Mazur, Natalia Nowak, Jędrzej Szymański, Wojciech Krauze, Chau-Jern Cheng & Małgorzata Kujawińska. (2023) Influence of Yokukansan on the refractive index of neuroblastoma cells. Biomedical Optics Express 14:5, pages 1959.
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Tatsuya Nogami, Koh Iwasaki, Hideo Kimura, Toru Higashi, Makoto Arai, James P. Butler, Masahiko Fujii & Hidetada Sasaki. (2023) Traditional Chinese medicine Jia Wei Gui Pi Tang improves behavioural and psychological symptoms of dementia and favourable positive emotions in patients. Psychogeriatrics 23:3, pages 503-511.
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Sujin Kim, Yunkwon Nam, Soo Jung Shin, Ritu Prajapati, Seong Min Shin, Min-Jeong Kim, Hyeon soo Kim, Seol Hwa Leem, Tae-Jin Kim, Yong Ho Park, Jwa-Jin Kim, Jae Sue Choi & Minho Moon. (2022) Dual modulators of aggregation and dissociation of amyloid beta and tau: In vitro, in vivo, and in silico studies of Uncaria rhynchophylla and its bioactive components. Biomedicine & Pharmacotherapy 156, pages 113865.
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Cheng-Hao Huang, Wen-Ling Liao, Der-Yen Lee, I-Ching Chou, Ming-Yu Wang & Ching-Liang Hsieh. (2022) Effects of Yi-Gan-san on the psychiatric behavior of children and adolescents with Tourette's Syndrome: A randomized, double-blind, controlled preliminary study. Journal of Ethnopharmacology 290, pages 115098.
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Hongxiu Zhang, Xiansu Chi, Wenchao Pan, Shijun Wang, Zhe Zhang, Haijun Zhao, Yuan Wang, Zhichun Wu, Miaomiao Zhou, Shan Ma, Qitao Zhao & Ke Ma. (2020) Antidepressant mechanism of classical herbal formula lily bulb and Rehmannia decoction: insights from gene expression profile of medial prefrontal cortex of mice with stress‐induced depression‐like behavior. Genes, Brain and Behavior 19:5.
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Anand Kumar Chaudhari, Somenath Das, Bijendra Kumar Singh, Jitendra Prasad, Nawal Kishore Dubey & Abhishek Kumar Dwivedy. 2020. Botanical Leads for Drug Discovery. Botanical Leads for Drug Discovery 29 49 .
Takashi Ozaki, Yuriko Katsumata & Asuna Arai. (2018) Association between changes in the use of psychotropic drugs and behavioural and psychological symptoms of dementia over 1 year among long‐term care facility residents. Psychogeriatrics 19:2, pages 126-134.
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Seong Gak Jeon, Eun Ji Song, Dongje Lee, Junyong Park, Yunkwon Nam, Jin-il Kim & Minho Moon. (2019) Traditional Oriental Medicines and Alzheimer’s Disease. Aging and disease 10:2, pages 307.
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Nanami Sameshima Uto, Haruka Amitani, Yuta Atobe, Yoshihiro Sameshima, Mika Sakaki, Natasya Rokot, Koji Ataka, Marie Amitani & Akio Inui. (2018) Herbal Medicine Ninjin'yoeito in the Treatment of Sarcopenia and Frailty. Frontiers in Nutrition 5.
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Nobuhiro Sugano, Toru Aoyama, Tsutomu Sato, Mariko Kamiya, Shinya Amano, Naoto Yamamoto, Takuya Nagashima, Yoshihiro Ishikawa, Katsuhiko Masudo, Masataka Taguri, Takeharu Yamanaka, Yuji Yamamoto, Hiroshi Matsukawa, Ryuji Shiraisi, Takashi Oshima, Norio Yukawa, Yasushi Rino & Munetaka Masuda. (2017) Randomized phase II study of TJ-54 (Yokukansan) for postoperative delirium in gastrointestinal and lung malignancy patients. Molecular and Clinical Oncology 7:4, pages 569-573.
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Ji-chun Zhang, Wei Yao, Youge Qu, Mayumi Nakamura, Chao Dong, Chun Yang, Qian Ren, Min Ma, Mei Han, Yukihiko Shirayama, Akiko Hayashi-Takagi & Kenji Hashimoto. (2017) Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype. Scientific Reports 7:1.
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Jun Matsumoto-Miyazaki, Hiroaki Ushikoshi, Shusaku Miyata, Nagisa Miyazaki, Takahide Nawa, Hideshi Okada, Shinsuke Ojio, Shinji Ogura & Shinya Minatoguchi. (2017) Acupuncture and Traditional Herbal Medicine Therapy Prevent Deliriumin Patients with Cardiovascular Disease in Intensive Care Units. The American Journal of Chinese Medicine 45:02, pages 255-268.
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Yoshihiko Nakatani, Taku Amano, Hikaru Yamamoto, Norio Sakai, Minoru Tsuji & Hiroshi Takeda. (2017) Yokukansan enhances the proliferation of B65 neuroblastoma. Journal of Traditional and Complementary Medicine 7:1, pages 34-44.
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Vijayasree V. Giridharan, Rajarajan A. Thandavarayan, Tetsuya Konishi & J. Quedevo. 2017. Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation. Japanese Kampo Medicines for the Treatment of Common Diseases: Focus on Inflammation 75 88 .
Keisuke Kondo, Satoshi Nakamura, Takahiro Kaneko, Norio Horie & Tetsuo Shimoyama. (2016) Unintentional self-injury of the tongue in an aged patient with Alzheimer's disease and behavioral and psychological symptoms of dementia, successfully treated with Kampo medicine: A case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 28:6, pages 551-554.
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Haidan Yuan, Qianqian Ma, Li Ye & Guangchun Piao. (2016) The Traditional Medicine and Modern Medicine from Natural Products. Molecules 21:5, pages 559.
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Hiromi Soraoka, Kentaro Oniki, Kazuki Matsuda, Tatsumasa Ono, Kosuke Taharazako, Yoshihiro Uchiyashiki, Ryoko Kamihashi, Ayana Kita, Ayaka Takashima, Kazuko Nakagawa, Norio Yasui-Furukori, Daisuke Kadowaki, Keishi Miyata & Junji Saruwatari. (2016) The Effect of <i>Yokukansan</i>, a Traditional Herbal Preparation Used for the Behavioral and Psychological Symptoms of Dementia, on the Drug–Metabolizing Enzyme Activities in Healthy Male Volunteers. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 39:9, pages 1468-1474.
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Kenji Hashimoto. (2015) Role of EphA4 signaling in the pathogenesis of amyotrophic lateral sclerosis and therapeutic potential of traditional Chinese medicine rhynchophylline. Psychopharmacology 232:15, pages 2873-2875.
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