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Original Research

Berberine exerts an anticonvulsant effect and ameliorates memory impairment and oxidative stress in a pilocarpine-induced epilepsy model in the rat

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Pages 2139-2145 | Published online: 13 Nov 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Qin Zhou, Huanjun Luo, Xiaowei Wang, Peng Li, Haibo Kong & Baomei He. (2022) Downregulation of miR-210 Promoted Apoptosis of Hippocampal Neurons by Negatively Regulating the TLR4/NF-кB1 Signaling Pathway in a Rat Model of Status Epilepticus. Neuropsychiatric Disease and Treatment 18, pages 1763-1770.
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Zhiyou Cai, Chuanling Wang & Wenming Yang. (2016) Role of berberine in Alzheimer’s disease. Neuropsychiatric Disease and Treatment 12, pages 2509-2520.
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Articles from other publishers (24)

Amira E. El-Nahas, Heba M. Elbedaiwy, Inas M. Masoud, Rania G. Aly, Maged W. Helmy & Amal H. El-Kamel. (2023) Berberine-loaded zein/hyaluronic acid composite nanoparticles for efficient brain uptake to alleviate neuro-degeneration in the pilocarpine model of epilepsy. European Journal of Pharmaceutics and Biopharmaceutics 188, pages 182-200.
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Bayan Sailike, Zhannur Omarova, Janar Jenis, Altynay Adilbayev, Burkitkan Akbay, Sholpan Askarova, Wei-Lin Jin & Tursonjan Tokay. (2022) Neuroprotective and anti-epileptic potentials of genus Artemisia L.. Frontiers in Pharmacology 13.
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Priyanka Saklani, Heena Khan, Thakur Gurjeet Singh, Saurabh Gupta & Amarjot Kaur Grewal. (2022) Demethyleneberberine, a potential therapeutic agent in neurodegenerative disorders: a proposed mechanistic insight. Molecular Biology Reports 49:10, pages 10101-10113.
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Era Seth & Mani Chopra. (2022) Neuroprotective efficacy of berberine following developmental exposure to chlorpyrifos in F1 generation of Wistar rats: Apoptosis-autophagy interplay. Science of The Total Environment 834, pages 155292.
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Ziqian Cheng, Chenglan Kang, Songtian Che, Jingyun Su, Qihan Sun, Tongtong Ge, Yi Guo, Jiayin Lv, Zhihui Sun, Wei Yang, Bingjin Li, Xin Li & Ranji Cui. (2022) Berberine: A Promising Treatment for Neurodegenerative Diseases. Frontiers in Pharmacology 13.
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Qin Zhou, Qiong Wang, Baomei He, Haibo Kong, Huanjun Luo, Xiaowei Wang & Wenlan Wang. (2022) MicroRNA 322-5p reduced neuronal inflammation via the TLR4/TRAF6/NF-κB axis in a rat epilepsy model. Open Medicine 17:1, pages 907-914.
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Ke Du, Miao He, Dongyi Zhao, Yuting Wang, Chao Ma, Hongyue Liang, Wuyang Wang, Dongyu Min, Lei Xue & Feng Guo. (2022) Mechanism of cell death pathways in status epilepticus and related therapeutic agents. Biomedicine & Pharmacotherapy 149, pages 112875.
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Katarina Živančević, Katarina Baralić, Dragica Bozic, Evica Antonijević Miljaković, Aleksandra Buha Djordjevic, Marijana Ćurčić, Zorica Bulat, Biljana Antonijević, Petar Bulat & Danijela Đukić-Ćosić. (2022) Involvement of environmentally relevant toxic metal mixture in Alzheimer's disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening. Food and Chemical Toxicology 161, pages 112839.
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Jia-Wen Shou & Pang-Chui Shaw. (2022) Therapeutic Efficacies of Berberine against Neurological Disorders: An Update of Pharmacological Effects and Mechanisms. Cells 11:5, pages 796.
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Moazzama Akbar, Anam Shabbir, Kanwal Rehman, Muhammad Sajid Hamid Akash & Muhammad Ajmal Shah. (2021) Neuroprotective potential of berberine in modulating Alzheimer’s disease via multiple signaling pathways. Journal of Food Biochemistry 45:10.
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Rong He, Wei Han, Xiaojie Song, Li Cheng, Hengsheng Chen & Li Jiang. (2021) Knockdown of Lingo-1 by short hairpin RNA promotes cognitive function recovery in a status convulsion model. 3 Biotech 11:7.
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Baoyue Zhang, Lizhen Wang, Xiuna Ji, Shanshan Zhang, Attila Sik, Kechun Liu & Meng Jin. (2020) Anti-Inflammation Associated Protective Mechanism of Berberine and its Derivatives on Attenuating Pentylenetetrazole-Induced Seizures in Zebrafish. Journal of Neuroimmune Pharmacology 15:2, pages 309-325.
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Mohsen Imenshahidi & Hossein Hosseinzadeh. 2020. Oxidative Stress and Dietary Antioxidants in Neurological Diseases. Oxidative Stress and Dietary Antioxidants in Neurological Diseases 199 216 .
Ning-Ning Yuan, Cui-Zan Cai, Ming-Yue Wu, Huan-Xing Su, Min Li & Jia-Hong Lu. (2019) Neuroprotective effects of berberine in animal models of Alzheimer’s disease: a systematic review of pre-clinical studies. BMC Complementary and Alternative Medicine 19:1.
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Hyun-Jong Jang, Ji-Eun Kim, Kyoung Jeong, Sung Lim, Seong Kim & Kyung-Ok Cho. (2019) The Neuroprotective Effect of Hericium erinaceus Extracts in Mouse Hippocampus after Pilocarpine-Induced Status Epilepticus. International Journal of Molecular Sciences 20:4, pages 859.
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Faheem Hyder Pottoo, Nahida Tabassum, Md. Noushad Javed, Shah Nigar, Rouqia Rasheed, Ayash Khan, Md. Abul Barkat, Md. Sabir Alam, Amir Maqbool, Mohammad Azam Ansari, George E. Barreto & Ghulam Md Ashraf. (2018) The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy. Molecular Neurobiology 56:2, pages 1233-1247.
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Yang-Min Zheng, Bo Chen, Jian-Dong Jiang & Jing-Pu Zhang. (2018) Syntaxin 1B Mediates Berberine’s Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model. Frontiers in Molecular Neuroscience 11.
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Alaa E. Ali, Heba M. Mahdy, Doaa M. Elsherbiny & Samar S. Azab. (2018) Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: Impact on oxidative, inflammatory and apoptotic machineries. Biochemical Pharmacology 156, pages 431-443.
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Xiaorui Lin & Nan Zhang. (2018) Berberine: Pathways to protect neurons. Phytotherapy Research 32:8, pages 1501-1510.
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Reza Sedaghat, Yosra Taab, Zahra Kiasalari, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad & Mehrdad Roghani. (2017) Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms. Biomedicine & Pharmacotherapy 87, pages 200-208.
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Juliana Sorraila de Oliveira, Fátima Husein Abdalla, Guilherme Lopes Dornelles, Stephen Adeniyi Adefegha, Taís Vidal Palma, Cristiane Signor, Jamile da Silva Bernardi, Jucimara Baldissarelli, Luana Suéling Lenz, Luana Pereira Magni, Maribel Antonello Rubin, Micheli Mainardi Pillat & Cinthia Melazzo de Andrade. (2016) Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer’s-like dementia: Involvement of acetylcholinesterase and cell death. NeuroToxicology 57, pages 241-250.
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Guldal Gulec Suyen, Naciye Isbil-Buyukcoskun, Nevzat Kahveci, Ece Sengun & Kasim Ozluk. (2016) Immediate and delayed treatment with gabapentin, carbamazepine and CNQX have almost similar impact on cognitive functions and behavior in the lithium-pilocarpine model in rats. Pharmacology Biochemistry and Behavior 148, pages 128-135.
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Masoumeh Seghatoleslam, Fatemeh Alipour, Reihaneh Shafieian, Zahra Hassanzadeh, Mohammad Amin Edalatmanesh, Hamid Reza Sadeghnia & Mahmoud Hosseini. (2016) The effects of Nigella sativa on neural damage after pentylenetetrazole induced seizures in rats. Journal of Traditional and Complementary Medicine 6:3, pages 262-268.
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Liming Yu, Qing Li, Bo Yu, Yang Yang, Zhenxiao Jin, Weixun Duan, Guolong Zhao, Mengen Zhai, Lijun Liu, Dinghua Yi, Min Chen & Shiqiang Yu. (2016) Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1. Oxidative Medicine and Cellular Longevity 2016, pages 1-16.
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