229
Views
36
CrossRef citations to date
0
Altmetric
Review

Novel class of medications, orexin receptor antagonists, in the treatment of insomnia – critical appraisal of suvorexant

&
Pages 239-247 | Published online: 14 Jul 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Kirsten C Morley, Christina J Perry, Joshua Watt, Tristan Hurzeler, Lorenzo Leggio, Andrew J Lawrence & Paul Haber. (2021) New approved and emerging pharmacological approaches to alcohol use disorder: a review of clinical studies. Expert Opinion on Pharmacotherapy 22:10, pages 1291-1303.
Read now

Articles from other publishers (35)

Shoki Okuda, Zaina P. Qureshi, Yukiko Yanagida, Chie Ito, Yuji Homma & Shigeru Tokita. (2023) Factors Associated with Prescriptions for an Orexin Receptor Antagonist Among Japanese Patients with Insomnia: Analysis of a Nationwide Japanese Claims Database. Drugs - Real World Outcomes 10:2, pages 271-281.
Crossref
Kazumaro Okino, Hirohisa Suzuki, Hiroi Tomioka, Kenji Sanada, Keita Kawai, Akira Iwanami & Atsuko Inamoto. (2023) Efficacy and safety of lemborexant as an alternative drug for patients with insomnia taking gamma‐aminobutyric acid–benzodiazepine receptor agonists or suvorexant. Human Psychopharmacology: Clinical and Experimental 38:3.
Crossref
Ryozo Yoshioka, Seiichiro Yamamoto & Eiji Nakatani. (2023) Effectiveness of suvorexant versus benzodiazepine receptor agonist sleep drugs in reducing the risk of hip fracture: Findings from a regional population-based cohort study. PLOS ONE 18:4, pages e0284726.
Crossref
Shoki Okuda, Zaina P. Qureshi, Yukiko Yanagida, Chie Ito, Yuji Homma & Shigeru Tokita. (2023) Hypnotic prescription trends and patterns for the treatment of insomnia in Japan: analysis of a nationwide Japanese claims database. BMC Psychiatry 23:1.
Crossref
Andrew H. Han, Caroline R. Burroughs, Evan P. Falgoust, Jamal Hasoon, Grace Hunt, Juyeon Kakazu, Tim Lee, Adam M. Kaye, Alan D. Kaye & Latha Ganti. (2023) Suvorexant, a Novel Dual Orexin Receptor Antagonist, for the Management of Insomnia. Health Psychology Research 10:5.
Crossref
Liwei Qin, Yanyan Luo, Hongjuan Chang, Hongxing Zhang, Zhiling Zhu, Yishen Du, Kaili Liu & Huimin Wu. (2023) The association between serum orexin-A levels and sleep quality in pregnant women. Sleep Medicine 101, pages 93-98.
Crossref
William W. Stoops, Justin C. Strickland, Kevin W. Hatton, Lon R. Hays, Abner O. Rayapati, Joshua A. Lile & Craig R. Rush. (2022) Suvorexant maintenance enhances the reinforcing but not subjective and physiological effects of intravenous cocaine in humans. Pharmacology Biochemistry and Behavior 220, pages 173466.
Crossref
Kazumaro Okino, Hirohisa Suzuki, Seiji Kondo, Hiroi Tomioka, Takahiro Tokumasu, Hiroki Yamada, Akira Iwanami & Atsuko Inamoto. (2022) Effectiveness of change from suvorexant to lemborexant drug in the treatment of sleep disorders. Psychogeriatrics 22:5, pages 595-604.
Crossref
Shintaro Shibata, Yasunori Oda, Nozomi Ohki, Yuki Ikemizu, Ryunosuke Hayatsu, Yuki Hirose & Masaomi Iyo. (2022) Narcolepsy-like symptoms triggered by lemborexant in the context of hyperactive delirium in a patient with bipolar depression: a case report. Journal of Clinical Sleep Medicine 18:5, pages 1459-1462.
Crossref
American Psychiatric Association. 2022. Diagnostic and Statistical Manual of Mental Disorders. Diagnostic and Statistical Manual of Mental Disorders.
Subhiksha Subramanian & Mirunalini Ravichandran. (2021) Orexin receptors: Targets and applications. Fundamental & Clinical Pharmacology 36:1, pages 72-80.
Crossref
Yun-Jo Lo, Viraj Krishna Mishra, Hung-Yao Lo, Navneet Kumar Dubey & Wen-Cheng Lo. (2022) Clinical Spectrum and Trajectory of Innovative Therapeutic Interventions for Insomnia: A Perspective. Aging and disease, pages 0.
Crossref
Jacqueline B. Mehr, Deborah Mitchison, Hannah E. Bowrey & Morgan H. James. (2021) Sleep dysregulation in binge eating disorder and “food addiction”: the orexin (hypocretin) system as a potential neurobiological link. Neuropsychopharmacology 46:12, pages 2051-2061.
Crossref
Kazumaro Okino, Hiroki Yamada, Hiroi Tomioka, Shinji Nozaki, Akira Iwanami & Atsuko Inamoto. (2021) Use of Suvorexant and Antipsychotics in the Treatment of Delirium After Infectious Diseases. Journal of Clinical Psychopharmacology 41:5, pages 589-593.
Crossref
Vallari Kothari, Zulma Cardona, Naricha Chirakalwasan, Thunyarat Anothaisintawee & Sirimon Reutrakul. (2021) Sleep interventions and glucose metabolism: systematic review and meta-analysis. Sleep Medicine 78, pages 24-35.
Crossref
Thomas C Neylan, Anne Richards, Thomas J Metzler, Leslie M Ruoff, Jonathan Varbel, Aoife O’Donovan, Melinda Sivasubramanian, Terri Motraghi, Jennifer Hlavin, Steven L Batki, Sabra S Inslicht, Kristin Samuelson, Stephen R Morairty & Thomas S Kilduff. (2020) Acute cognitive effects of the hypocretin receptor antagonist almorexant relative to zolpidem and placebo: a randomized clinical trial. Sleep 43:10.
Crossref
Carrie E Mahoney, Takatoshi Mochizuki & Thomas E Scammell. (2020) Dual orexin receptor antagonists increase sleep and cataplexy in wild type mice. Sleep 43:6.
Crossref
Ying Han, Kai Yuan, Yongbo Zheng & Lin Lu. (2019) Orexin Receptor Antagonists as Emerging Treatments for Psychiatric Disorders. Neuroscience Bulletin 36:4, pages 432-448.
Crossref
Dongmei He, Binghu Jiang, Zhiwei Guo, Qiwen Mu & Morgan A Mcclure. (2020) Biphasic feature of placebo response in primary insomnia: pooled analysis of data from randomized controlled clinical trials of orexin receptor antagonists. Sleep 43:3.
Crossref
Mingda Yang, Hui Ma, Meng Jia, Yijing Li, Degen Miao, Cailian Cui & Liuzhen Wu. (2020) The role of the nucleus accumbens OXR1 in cocaine-induced locomotor sensitization. Behavioural Brain Research 379, pages 112365.
Crossref
Elda Arrigoni, Melissa J.S. Chee & Patrick M. Fuller. (2019) To eat or to sleep: That is a lateral hypothalamic question. Neuropharmacology 154, pages 34-49.
Crossref
Kazuomi Kario, Koichiro Yamasaki, Kazuro Yagi, Masatoshi Tsukamoto, Shoji Yamazaki, Yukie Okawara, Naoko Tomitani & Hiroshi Kanegae. (2019) Effect of suvorexant on nighttime blood pressure in hypertensive patients with insomnia: The SUPER‐1 study. The Journal of Clinical Hypertension 21:7, pages 896-903.
Crossref
W. Joseph Herring, Thomas Roth, Andrew D. Krystal & David Michelson. (2018) Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications. Journal of Sleep Research 28:2.
Crossref
J. F. Pagel, Seithikurippu R. Pandi-Perumal & Jaime M. Monti. (2018) Treating insomnia with medications. Sleep Science and Practice 2:1.
Crossref
Jacob Vigil, Sarah Stith, Jegason Diviant, Franco Brockelman, Keenan Keeling & Branden Hall. (2018) Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions. Medicines 5:3, pages 75.
Crossref
Graeme Milligan. (2018) G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35. British Journal of Pharmacology 175:13, pages 2543-2553.
Crossref
Suzana Monteiro, Barbara Monteiro, Flavia Paes, Antônio Egídio Nardi, Nuno Rocha, Eric Murillo-Rodriguez & Sergio Machado. (2018) Neurobiological Role of Hypocretin in Regulation of Psychiatric Disorders. Sleep and Vigilance 2:1, pages 33-38.
Crossref
Masakazu Hatano, Hiroyuki Kamei, Risa Inagaki, Haruna Matsuzaki, Manako Hanya, Shigeki Yamada & Nakao Iwata. (2018) Assessment of Switching to Suvorexant versus the Use of Add-on Suvorexant in Combination with Benzodiazepine Receptor Agonists in Insomnia Patients: A Retrospective Study. Clinical Psychopharmacology and Neuroscience 16:2, pages 184-189.
Crossref
S. Mukerjee & E. Lazartigues. (2018) Sympathetic nerve activity and neuro-inflammation: Who is in the driver's seat?. Acta Physiologica 222:2, pages e13011.
Crossref
Stéphanie Dayot, Daniela Speisky, Anne Couvelard, Pierre Bourgoin, Valérie Gratio, Jérôme Cros, Vinciane Rebours, Alain Sauvanet, Pierre Bedossa, Valérie Paradis, Philippe Ruszniewski, Alain Couvineau & Thierry Voisin. (2018) In vitro , in vivo and ex vivo demonstration of the antitumoral role of hypocretin-1/orexin-A and almorexant in pancreatic ductal adenocarcinoma . Oncotarget 9:6, pages 6952-6967.
Crossref
Jaime M. Monti, Pablo Torterolo, David Warren Spence & Seithikurippu R. Pandi-Perumal. (2017) Selective Serotonin 5-HT2A Receptor Antagonists and Inverse Agonists Specifically Promote Slow Wave Sleep (Stage N3) in Man. Sleep and Vigilance 2:1, pages 23-31.
Crossref
Jiaye Jiang, Zhongyuan Gan, Yuan Li, Wenqi Zhao, Hanqing Li, Jian-Pu Zheng & Yan Ke. (2017) REM sleep deprivation induces endothelial dysfunction and hypertension in middle-aged rats: Roles of the eNOS/NO/cGMP pathway and supplementation with L-arginine. PLOS ONE 12:8, pages e0182746.
Crossref
P. Schneider & G. Schneider. (2017) De-orphaning the marine natural product (±)-marinopyrrole A by computational target prediction and biochemical validation. Chemical Communications 53:14, pages 2272-2274.
Crossref
Jun Kohyama. (2016) Possible neuronal mechanisms of sleep disturbances in patients with autism spectrum disorders and attention-deficit/hyperactivity disorder. Medical Hypotheses 97, pages 131-133.
Crossref
William Stoops, Justin C. Strickland, Kevin W. Hatton, Lon R. Hays, Abner O. Rayapati, Joshua A. Lile & Craig R. Rush. (2022) Suvorexant Maintenance Enhances the Reinforcing But Not Subjective and Physiological Effects of Intravenous Cocaine in Humans. SSRN Electronic Journal.
Crossref