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Review

The role of inhaled methoxyflurane in acute pain management

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Pages 149-164 | Published online: 18 Oct 2018

Keep up to date with the latest research on this topic with citation updates for this article.

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Eric A. Zizzi, Marco Cavaglià, Jack A. Tuszynski & Marco A. Deriu. (2022) Insights into the interaction dynamics between volatile anesthetics and tubulin through computational molecular modelling. Journal of Biomolecular Structure and Dynamics 40:16, pages 7324-7338.
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Waiting Tai & Philip Chi Lip Kwok. (2022) Recent advances in drug delivery to the central nervous system by inhalation. Expert Opinion on Drug Delivery 19:5, pages 539-558.
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Andrea Fabbri, Alberto M Borobia, Agnes Ricard-Hibon, Frank Coffey, Aurore Caumont-Prim, François Montestruc, Amedeo Soldi, Susana Traseira Lugilde & Sara Dickerson. (2021) Low-Dose Methoxyflurane versus Standard of Care Analgesics for Emergency Trauma Pain: A Systematic Review and Meta-Analysis of Pooled Data. Journal of Pain Research 14, pages 93-105.
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Sossio Serra, Antonio Voza, Germana Ruggiano, Andrea Fabbri, Elisabetta Bonafede, Antonella Sblendido, Amedeo Soldi & Alberto Farina. (2020) Efficacy, Practicality, and Safety of Inhaled Methoxyflurane in Elderly Patients with Acute Trauma Pain: Subgroup Analysis of a Randomized, Controlled, Multicenter, Open-Label Trial (MEDITA). Journal of Pain Research 13, pages 1777-1784.
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Antonio Voza, Germana Ruggiano, Sossio Serra, Giuseppe Carpinteri, Gianfilippo Gangitano, Fabio Intelligente, Elisabetta Bonafede, Antonella Sblendido, Alberto Farina, Amedeo Soldi & Andrea Fabbri. (2020) Inhaled Methoxyflurane versus Intravenous Morphine for Severe Trauma Pain in the Emergency Setting: Subgroup Analysis of MEDITA, a Multicenter, Randomized, Controlled, Open-Label Trial. Journal of Pain Research 13, pages 491-502.
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Andrew D Xia, Sara L Dickerson, Andrew Watson, Mika Nokela, Sam Colman & Agota Szende. (2019) Evaluation of pain relief treatment and timelines in emergency care in six European countries and Australia. Open Access Emergency Medicine 11, pages 229-240.
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Articles from other publishers (32)

Daniel Aiham Ghazali, Donia Bouzid, Alix Frachon, Sarah Ait-Abdesselam, Philippe Kenway, Christophe Choquet & Enrique Casalino. (2023) Pain Self-Management with Inhaled Methoxyflurane by Emergency Department Trauma Patients: A Prospective, Interventional, Single-Center Study. International Journal of Environmental Research and Public Health 20:12, pages 6107.
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Mandy Wong, Kurosh Parsi, Kenneth Myers, Marianne De Maeseneer, Joseph Caprini, Attilio Cavezzi, David E Connor, Alun H Davies, Sergio Gianesini, Jean-Luc Gillet, Louis Grondin, Jean-Jérôme Guex, Claudine Hamel-Desnos, Nick Morrison, Giovanni Mosti, Alvaro Orrego, Hugo Partsch, Eberhard Rabe, Pauline Raymond-Martimbeau, Michel Schadeck, Roberto Simkin, Lorenzo Tessari, Paul K Thibault, Jorge H Ulloa, Mark Whiteley, Takashi Yamaki, Steven Zimmet, Mina Kang, Selene Vuong, Anes Yang & Lois Zhang. (2023) Sclerotherapy of lower limb veins: Indications, contraindications and treatment strategies to prevent complications – A consensus document of the International Union of Phlebology-2023. Phlebology: The Journal of Venous Disease 38:4, pages 205-258.
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Susan Hanson, Ashley Hanson & Dominic Aldington. (2023) Pain priorities in pre-hospital care. Anaesthesia & Intensive Care Medicine.
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Ann Du, Liam Hannan & Sanjeevan Muruganandan. (2023) A narrative review on pain control interventions for non-surgical pleural procedures. Respiratory Medicine 207, pages 107119.
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Hany Zaki, Süha Türkmen, Aftab Azad, Khalid Bashir, Amr Elmoheen, Eman Shaban, Haris Iftikhar & Nabil Shallik. (2023) Clinical assessment and risk stratification for prehospital use of methoxyflurane versus standard analgesia in adult patients with trauma pain. Turkish Journal of Emergency Medicine 23:2, pages 65.
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Nancy Grisel Cortés-Castillo, Orlando Carrillo-Torres & Verónica Camacho-Vacherón. (2023) El resurgimiento del metoxiflurano en México. Revista Mexicana de Anestesiología 46:1, pages 32-37.
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Helmut Trimmel, Alexander Egger, Reinhard Doppler, Mathias Pimiskern & Wolfgang G. Voelckel. (2022) Usability and effectiveness of inhaled methoxyflurane for prehospital analgesia - a prospective, observational study. BMC Emergency Medicine 22:1.
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Anwyn Pyle, Erin Kelty, Frank Sanfilippo, Kevin Murray & David Preen. (2022) Prevalence and Perinatal Outcomes Following In Utero Exposure to Prehospital Emergency Methoxyflurane: A 17-Year Retrospective Cohort Study. Pediatric Drugs 24:5, pages 547-554.
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CEB Gray Stephens, A Dias, E Skinner, C Brennan, RG Middleton & CK Angel. (2022) Penthrox enables quicker management of fractures, dislocations and more: learning lessons from expedited care of trauma patients during the COVID-19 pandemic. The Annals of The Royal College of Surgeons of England.
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Pieter Dylst, Angela Solaman, Marc Gillis, Sara Dickerson, James Kenworthy & Saïd Hachimi-Idrissi. (2021) Healthcare resource use and cost implications of low dose methoxyflurane for severe trauma-related pain: a qualitative study. Trauma 24:3, pages 248-256.
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Simon Downs, Nicola Carey & Freda Mold. (2022) Barriers and facilitators to out-of-hospital pain management for children. Journal of Paramedic Practice 14:4, pages 1-11.
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Helmut Trimmel, Alexander Egger, Reinhard Doppler, Christoph Beywinkler, Wolfgang G. Voelckel & Janett Kreutziger. (2021) Volatile Anästhetika zur präklinischen Analgesie durch Rettungssanitäter – Eine ÜbersichtVolatile anesthetics for prehospital analgesia by paramedics—An overview. Der Anaesthesist 71:3, pages 233-242.
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J Málek. (2022) Year 2021 in review - Perioperative pain therapy. Anesteziologie a intenzivní medicína 32:6, pages 265-270.
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Bhavana Yalamuru, Tejinder S. Swaran Singh & Peter Lax. 2022. Textbook of Acute Trauma Care. Textbook of Acute Trauma Care 243 272 .
Michael M. Eager, Grant S. Nolan, Kathryn Tonks, Anoopama Ramjeeawon & Natalie Taylor. (2021) Inhaled methoxyflurane (Penthrox) for analgesia in trauma: a systematic review protocol. Systematic Reviews 10:1.
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Christopher Bond, Lauren Westafer, Kirsty Challen & William K. Milne. (2021) Hot off the press: the RAMPED trial—methoxyflurane for analgesia in the emergency department. Academic Emergency Medicine 28:10, pages 1179-1182.
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Aldona Kubica, Agata Kosobucka, Piotr Niezgoda, Piotr Adamski, Katarzyna Buszko, Maciej Lesiak, Wojciech Wojakowski, Mariusz Gasior, Jarosław Gorący, Andrzej Kleinrok, Klaudiusz Nadolny, Eliano Navarese & Jacek Kubica. (2021) ANalgesic Efficacy and safety of MOrphiNe versus methoxyflurane in patients with acute myocardial infarction: the rationale and design of the ANEMON-SIRIO 3 study: a multicentre, open-label, phase II, randomised clinical trial. BMJ Open 11:3, pages e043330.
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Danielle Fontaine & Melissa Red Hoffman. (2020) Management of Acute Pain Due to Traumatic Injury in Patients with Chronic Pain and Pre-injury Opioid Use. Current Trauma Reports 7:1, pages 24-32.
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James R. Miner. (2021) Why don’t we have better pain treatments?. Academic Emergency Medicine 28:2, pages 260-262.
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Lisa Brichko, Ravali Gaddam, Cristina Roman, Gerard O’Reilly, Carl Luckhoff, Paul Jennings, De Villiers Smit, Peter Cameron & Biswadev Mitra. (2020) Rapid Administration of Methoxyflurane to Patients in the Emergency Department (RAMPED) Study: A Randomized Controlled Trial of Methoxyflurane Versus Standard Care. Academic Emergency Medicine 28:2, pages 164-171.
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Himawan Fernando, James A. Shaw, Paul S. Myles, Karlheinz Peter & Dion Stub. (2021) The opioid-P2Y12 inhibitor interaction: Potential strategies to mitigate the interaction and consideration of alternative analgesic agents in myocardial infarction. Pharmacology & Therapeutics 217, pages 107665.
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Agnès Ricard-Hibon, Nathalie Lecoules, Dominique Savary, Laurent Jacquin, Eric Wiel, Patrick Deschamps, Marion Douplat, François Montestruc, Bérangère Chomier, Karim Tazarourte & Frédéric Adnet. (2020) Inhaled methoxyflurane for the management of trauma related pain in patients admitted to hospital emergency departments: a randomised, double-blind placebo-controlled trial (PenASAP study). European Journal of Emergency Medicine 27:6, pages 414-421.
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MA Wellbeloved, R Parkhurst & KH Keeling. (2020) Efficacy of inhaled methoxyflurane for procedural analgesia in paediatric burns: a pilot study. Southern African Journal of Anaesthesia and Analgesia, pages 235-239.
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Hugo M L Cohen & R Wolstenholme. (2020) Penthrox: a breath of PHEC air for the military?. BMJ Military Health 166:4, pages 257-260.
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Susan Hanson, Ashley Hanson & Dominic Aldington. (2020) Pain priorities in pre-hospital care. Anaesthesia & Intensive Care Medicine 21:8, pages 387-389.
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Virginie Eve Lvovschi, Maxime Maignan, Karim Tazarourte, Mohamed Lamine Diallo, Caroline Hadjadj-Baillot, Nathalie Pons-Kerjean, Frederic Lapostolle & Claude Dussart. (2020) Multiple criteria decision analysis approach to consider therapeutic innovations in the emergency department: The methoxyflurane organizational impact in acute trauma pain. PLOS ONE 15:4, pages e0231571.
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Alberto M. Borobia, Sergio García Collado, César Carballo Cardona, Rosa Capilla Pueyo, Cesáreo Fernández Alonso, Ignacio Pérez Torres, María Corell González, José Ramón Casal Codesido, María Arranz Betegón, Luis Amador Barcela, Aitor Odiaga Andicoechea, Anselma Fernández Testa, Jorge Trigo Colina, Antonio Cid Dorribo, Carmen del Arco Galán, Jose Carlos Martínez Ávila, Susana Traseira Lugilde, Antonio J. Carcas Sansuán, Claudio Bueno Marisca, Pedro Mesa Rodríguez, Emilio Montero Romero, José Lázaro González, María A. Jañez Álvarez, Roberto Rodríguez Alonso, Javier del Castillo Nos, Manuel V. Duran Ruiz, Pere Llorens Soriano, Wilkins Poy, Luis Sanchez Santos, Fátima Barcala del Caño, Ángela Dopico García, Paula Núñez Gaviño, Elena Sánchez Fernández Linares, Jose Valle Cruz, Norma B. Sanz Cadenas, Maite Ayuso Aragonés, Lubna Dani, Olga González Peña, María M. Jaén Cañadas, Mikel Rico Briñas, Yale Tung Cheng, Isabel López Isidro, Laura Ferrer Armengou, Paula Molina Ávila, Amaia Etxebarria Gulías, Kristina García Lombardía & Patricia Wunderling Brüggenmann. (2020) Inhaled Methoxyflurane Provides Greater Analgesia and Faster Onset of Action Versus Standard Analgesia in Patients With Trauma Pain: InMEDIATE: A Randomized Controlled Trial in Emergency Departments. Annals of Emergency Medicine 75:3, pages 315-328.
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John Frangos, Anissa Belbachir, Sandrine Dautheville, Christiane Jung, Key Herklotz, Freya Amon, Sara Dickerson & Berangere Chomier. (2020) Non-interventional study evaluating exposure to inhaled, low-dose methoxyflurane experienced by hospital emergency department personnel in France. BMJ Open 10:2, pages e034647.
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Teck Nam Ang, Isuru A. Udugama, Seyed Soheil Mansouri, Matthew Taylor, Rob Burrell, Brent R. Young & Saeid Baroutian. (2019) A techno-economic-societal assessment of recovery of waste volatile anaesthetics. Separation and Purification Technology 226, pages 304-314.
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Sebastiano Mercadante, Antonio Voza, Sossio Serra, Germana Ruggiano, Giuseppe Carpinteri, Gianfilippo Gangitano, Fabio Intelligente, Elisabetta Bonafede, Antonella Sblendido, Alberto Farina, Amedeo Soldi & Andrea Fabbri. (2019) Analgesic Efficacy, Practicality and Safety of Inhaled Methoxyflurane Versus Standard Analgesic Treatment for Acute Trauma Pain in the Emergency Setting: A Randomised, Open-Label, Active-Controlled, Multicentre Trial in Italy (MEDITA). Advances in Therapy 36:11, pages 3030-3046.
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