Advanced search
Publication Cover
Open Access Journal of Clinical Trials Volume 6, 2014 - Issue
Submit an article Journal homepage
150
Views
15
CrossRef citations to date
0
Altmetric
Original Research

TRANSFORM: a novel study design to evaluate the effect of everolimus on long-term outcomes after kidney transplantation

Julio Pascual1 Nephrology Department, Hospital del Mar, Barcelona, SpainCorrespondence[email protected]
,
Titte R Srinivas2 Division of Nephrology, Medical University of South Carolina, Mt Pleasant, SC, USA
,
Steven Chadban3 Department of Transplantation, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
,
Franco Citterio4 Centro Trapianti d’Organo Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Policlinico Universitario A Gemelli, Rome, Italy
,
Federico Oppenheimer5 Renal Transplant Unit, Hospital Clínic de Barcelona, Barcelona, Spain
,
Helio Tedesco6 Nephrology Division, Hospital do Rim, UNIFESP, São Paulo, Brazil
,
Mitchell L Henry7 The Comprehensive Transplant Center, The Ohio State University, Wexner Medical Center, Columbus, OH, USA
,
Christophe Legendre8 Service de Transplantation Adultes, Université Paris Descartes and Hôpital Necker, Paris, France
,
Yoshihiko Watarai9 Department of Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya City, Aich, Japan
,
Claudia Sommerer10 Medizinische Klinik, Sektion Nephrologie, Universitätsklinikum Heidelberg, Heidelberg, Germany
,
Po-Chang Lee11 Medical College, National Cheng Kung University, Tainan City, Taiwan
,
J Mark Hexham12 Biometrics and Statistical Science, Novartis Pharmaceuticals, East Hanover, NJ, USA
,
Gaohong Dong12 Biometrics and Statistical Science, Novartis Pharmaceuticals, East Hanover, NJ, USA
,
Peter Bernhardt13 Research and Development, Novartis Pharma AG, Basel, Switzerland
&
Flavio Vincenti14 Kidney Transplant Service, University of California San Francisco, San Francisco, CA, USA
 show all
Pages 45-54 | Published online: 10 Jun 2014

Citations (15)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Franco Citterio, Mitchell Henry, Dean Y Kim, Myoung Soo Kim, Duck-Jong Han, Takashi Kenmochi, Eytan Mor, Giuseppe Tisone, Peter Bernhardt, Maria Pilar Hernandez Gutierrez & Yoshihiko Watarai. (2020) Wound healing adverse events in kidney transplant recipients receiving everolimus with reduced calcineurin inhibitor exposure or current standard-of-care: insights from the 24-month TRANSFORM study. Expert Opinion on Drug Safety 19:10, pages 1339-1348.
Read now

Articles from other publishers (14)

Yoshihiko Watarai, Romina Danguilan, Concesa Casasola, Shen‐Shin Chang, Prajej Ruangkanchanasetr, Terence Kee, Hin Seng Wong, Takashi Kenmochi, Angel Joaquin Amante, Kuo‐Hsiung Shu, Atiporn Ingsathit, Peter Bernhardt, Maria Pilar Hernandez‐Gutierrez, Duck Jong Han & Myoung Soo Kim. (2021) Everolimus‐facilitated calcineurin inhibitor reduction in Asian de novo kidney transplant recipients: 2‐year results from the subgroup analysis of the TRANSFORM study. Clinical Transplantation 35:10.
Crossref
Herman Veenhof, Remco A. Koster, Jan-Willem C. Alffenaar, Aad P. van den Berg, Marco R. de Groot, Erik A.M. Verschuuren, Stefan P. Berger, Stephan J.L. Bakker & Daan J. Touw. (2019) Clinical application of a dried blood spot assay for sirolimus and everolimus in transplant patients. Clinical Chemistry and Laboratory Medicine (CCLM) 57:12, pages 1854-1862.
Crossref
Stefan P. Berger, Claudia Sommerer, Oliver Witzke, Helio Tedesco, Steve Chadban, Shamkant Mulgaonkar, Yasir Qazi, Johan W. de Fijter, Federico Oppenheimer, Josep M. Cruzado, Yoshihiko Watarai, Pablo Massari, Christophe Legendre, Franco Citterio, Mitchell Henry, Titte R. Srinivas, Flavio Vincenti, Maria Pilar Hernandez Gutierrez, Ana Maria Marti, Peter Bernhardt & Julio Pascual. (2019) Two-year outcomes in de novo renal transplant recipients receiving everolimus-facilitated calcineurin inhibitor reduction regimen from the TRANSFORM study. American Journal of Transplantation 19:11, pages 3018-3034.
Crossref
Julio Pascual, Stefan P. Berger, Steven J. Chadban, Franco Citterio, Nassim Kamar, Dennis A. Hesselink, Christophe Legendre, Ute Eisenberger, Federico Oppenheimer, Graeme R. Russ, Claudia Sommerer, Paolo Rigotti, Titte R. Srinivas, Yoshihiko Watarai, Mitchell L. Henry, Flavio Vincenti & Helio Tedesco-Silva. (2019) Evidence-based practice: Guidance for using everolimus in combination with low-exposure calcineurin inhibitors as initial immunosuppression in kidney transplant patients. Transplantation Reviews 33:4, pages 191-199.
Crossref
Claudia Sommerer, Barbara Suwelack, Duska Dragun, Peter Schenker, Ingeborg A. Hauser, Oliver Witzke, Christian Hugo, Nassim Kamar, Pierre Merville, Martina Junge, Friedrich Thaiss, Björn Nashan, Eric Almartine, Jacques Dantal, Duska Dragun, Thorsten Feldkamp, Ingeborg A. Hauser, Marc Hazzan, Nils Heyne, Christian Hugo, Nassim Kamar, Philippe Lang, Frank Lehner, Yannick Le Meur, Jens Lutz, Pierre Merville, Emmanuel Morelon, Bruno Moulin, Christiane Mousson, Anja Muehlfeld, Björn Nashan, Przemyslaw Pisarski, Eric Rondeau, Peter Schenker, Claudia Sommerer, Barbara Suwelack, Friedrich Thaiss, Antoine Thierry, Michael Wiesener & Oliver Witzke. (2019) An open-label, randomized trial indicates that everolimus with tacrolimus or cyclosporine is comparable to standard immunosuppression in de novo kidney transplant patients. Kidney International 96:1, pages 231-244.
Crossref
Sofia D. Viana, Flávio Reis & Rui Alves. (2018) Therapeutic Use of mTOR Inhibitors in Renal Diseases: Advances, Drawbacks, and Challenges. Oxidative Medicine and Cellular Longevity 2018, pages 1-17.
Crossref
Philippe Grimbert & Olivier Thaunat. (2017) mTOR inhibitors and risk of chronic antibody-mediated rejection after kidney transplantation: where are we now?. Transplant International 30:7, pages 647-657.
Crossref
Y. Qazi, D. Shaffer, B. Kaplan, D.Y. Kim, F.L. Luan, V.R. Peddi, F. Shihab, S. Tomlanovich, S. Yilmaz, K. McCague, D. Patel & S. Mulgaonkar. (2017) Efficacy and Safety of Everolimus Plus Low-Dose Tacrolimus Versus Mycophenolate Mofetil Plus Standard-Dose Tacrolimus in De Novo Renal Transplant Recipients: 12-Month Data. American Journal of Transplantation 17:5, pages 1358-1369.
Crossref
Julio Pascual, Fritz Diekmann, Constantino Fernández-Rivera, Gonzalo Gómez-Marqués, Alex Gutiérrez-Dalmau, María José Pérez-Sáez, Asunción Sancho-Calabuig & Federico Oppenheimer. (2017) Recommendations for the use of everolimus in de novo kidney transplantation: False beliefs, myths and realities. Nefrología (English Edition) 37:3, pages 253-266.
Crossref
Julio Pascual, Fritz Diekmann, Constantino Fernández-Rivera, Gonzalo Gómez-Marqués, Alex Gutiérrez-Dalmau, María José Pérez-Sáez, Asunción Sancho-Calabuig & Federico Oppenheimer. (2017) Recomendaciones para el uso de everolimus en trasplante renal de novo: falsas creencias, mitos y realidades. Nefrología 37:3, pages 253-266.
Crossref
Alexandra Ferreira, Claudia Felipe, Marina Cristelli, Laila Viana, Geovana Basso, Suelen Stopa, Juliana Mansur, Mayara Ivani, Adrieli Bessa, Priscila Ruppel, Wilson Aguiar, Erika Campos, Maria Gerbase-DeLima, Henrique Proença, Helio Tedesco-Silva & José Medina-Pestana. (2017) Donor-Specific Anti-Human Leukocyte Antigens Antibodies, Acute Rejection, Renal Function, and Histology in Kidney Transplant Recipients Receiving Tacrolimus and Everolimus. American Journal of Nephrology 45:6, pages 497-508.
Crossref
Leonardo V. Riella, Arjang Djamali & Julio Pascual. (2017) Chronic allograft injury: Mechanisms and potential treatment targets. Transplantation Reviews 31:1, pages 1-9.
Crossref
Oliver Witzke, Claudia Sommerer & Wolfgang Arns. (2016) Everolimus immunosuppression in kidney transplantation: What is the optimal strategy?. Transplantation Reviews 30:1, pages 3-12.
Crossref
Titte R. Srinivas & Federico Oppenheimer. (2015) Identifying endpoints to predict the influence of immunosuppression on long-term kidney graft survival. Clinical Transplantation 29:7, pages 644-653.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.