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Review

Intense pulsed light for evaporative dry eye disease

Pages 1167-1173 | Published online: 20 Jun 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

James Chelnis, Chantel N Garcia & Haya Hamza. (2023) Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction. Clinical Ophthalmology 17, pages 3089-3102.
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Alfredo Borgia, Raffaele Raimondi, Giovanni Fossati, Francesco Paolo De Rosa, Vito Romano, Davide Borroni, Luca Vigo, Vincenzo Scorcia & Giuseppe Giannaccare. (2022) Device-based therapies as a boost of conventional treatment in dry eye disease. Expert Review of Ophthalmology 17:6, pages 387-393.
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Ngamjit Kasetsuwan, Lita Uthaithammarat, Yonrawee Piyacomn, Usanee Reinprayoon, Chayanon Chatchavalvanich & Ratchathorn Panchaprateep. (2021) Effectiveness and Safety of Combined Application of Three Modes of 2940-nm Erbium:YAG and 1064-nm Neodymium:YAG Lasers in Treatment of Meibomian Gland Dysfunction. Clinical Ophthalmology 15, pages 3065-3073.
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Samantha Sagaser, Richard Butterfield, Heidi Kosiorek, Yael Kusne, Juan Maldonado, Michael P Fautsch, Dharmendra Patel & Joanne F Shen. (2021) Effects of Intense Pulsed Light on Tear Film TGF-β and Microbiome in Ocular Rosacea with Dry Eye. Clinical Ophthalmology 15, pages 323-330.
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Carlos Vergés, José Salgado-Borges, Francesc March de Ribot & Verónica Ribas. (2021) Current developments of intensive pulsed light treatment for dry eye disease and meibomian gland dysfunction. Expert Review of Ophthalmology 16:5, pages 401-409.
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Michael T. M. Wang, Umaima Khatoon & Jennifer P. Craig. (2020) The use of intense pulsed light therapy in the treatment of refractory meibomian gland dysfunction. Expert Review of Ophthalmology 15:4, pages 197-200.
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Giuseppe Giannaccare, Leonardo Taroni, Carlotta Senni & Vincenzo Scorcia. (2019) Intense Pulsed Light Therapy In The Treatment Of Meibomian Gland Dysfunction: Current Perspectives. Clinical Optometry 11, pages 113-126.
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Karl Stonecipher, Thomas G Abell, Bennett Chotiner, Erik Chotiner & Rick Potvin. (2019) Combined low level light therapy and intense pulsed light therapy for the treatment of meibomian gland dysfunction. Clinical Ophthalmology 13, pages 993-999.
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Articles from other publishers (63)

A.-A. Benyoussef, F. Arzel & B. Cochener. (2023) 3-month post-procedural evaluation of a combined intense pulsed light and photo-biomodulation system in the treatment of meibomian gland dysfunction. Journal Français d'Ophtalmologie.
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Hongya ZengLan Gong. (2023) A Review of Applications and Intracellular Mechanisms of Intense Pulsed Light in Eyelid Inflammatory Diseases. Photobiomodulation, Photomedicine, and Laser Surgery 41:3, pages 104-119.
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Victor L. Perez, Hazem M. Mousa, Matias Soifer, Cole Beatty, Stefanie Sarantopoulos, Daniel R. Saban & Robert B. Levy. (2023) Meibomian Gland Dysfunction: A Route of Ocular Graft-Versus-Host Disease Progression That Drives a Vicious Cycle of Ocular Surface Inflammatory Damage. American Journal of Ophthalmology 247, pages 42-60.
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Joseph Tauber. 2023. Dry Eye Disease. Dry Eye Disease 213 220 .
Peiyu Jiang, Yunyi Liu, Jiawen Zhang, Yixuan Liu, Min Li, Meng Tao, Yue Zhang, Zongxiang Tang, Wentao Liu & Yang Xu. (2022) Mast cell stabilization: new mechanism underlying the therapeutic effect of intense pulsed light on rosacea. Inflammation Research 72:1, pages 75-88.
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Luca Vigo, Marco Pellegrini, Francesco Carones, Vincenzo Scorcia & Giuseppe Giannaccare. (2022) Outcomes of serial sessions of Activa mask combined with intense pulsed light therapy in patients with Meibomian gland dysfunction. BMC Ophthalmology 22:1.
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Jiachen Yuan, Yang Gao, Longquan Pi, Zhouna Li, Meilan Nan, Zhehu Jin & Chenglong Jin. (2022) Novel technique for rosacea treatment using optimal pulse technology: In vivo and clinical studies. Journal of Cosmetic Dermatology 21:12, pages 6767-6775.
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Jeremy J. Kudrna, Clever Nguyen & Gargi K. Vora. (2022) Intense Pulse Light Therapy for Meibomian Gland Dysfunction. Current Ophthalmology Reports 10:4, pages 138-152.
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Sen Miao, Ran Yan, Yusong Jia & Zhiqiang Pan. (2022) Effect of Intense Pulsed Light Therapy in Dry Eye Disease Caused by Meibomian Gland Dysfunction: A Systematic Review and Meta-Analysis. Eye & Contact Lens: Science & Clinical Practice 48:10, pages 424-429.
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Reiko Arita & Shima Fukuoka. (2022) Therapeutic Efficacy and Safety of Intense Pulsed Light for Refractive Multiple Recurrent Chalazia. Journal of Clinical Medicine 11:18, pages 5338.
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Sharon D'Souza, Archana Padmanabhan Nair, Gowtham Iyappan, Mor M. Dickman, Prashansa Thakur, Ritika Mullick, Gairik Kundu, Swaminathan Sethu, Arkasubhra Ghosh & Rohit Shetty. (2022) Clinical and Molecular Outcomes After Combined Intense Pulsed Light Therapy With Low-Level Light Therapy in Recalcitrant Evaporative Dry Eye Disease With Meibomian Gland Dysfunction. Cornea 41:9, pages 1080-1087.
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A. Caravaca, J.L. Alió del Barrio, M.C. Martínez Hergueta & M.A. Amesty. (2022) Intense pulsed light combined with meibomian gland expression for chalazion management. Archivos de la Sociedad Española de Oftalmología (English Edition) 97:9, pages 490-496.
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A. Caravaca, J.L. Alió del Barrio, M.C. Martínez Hergueta & M.A. Amesty. (2022) Luz pulsada intensa combinada con expresión de las glándulas de Meibomio para el tratamiento del chalación. Archivos de la Sociedad Española de Oftalmología 97:9, pages 490-496.
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Yunhan Lee, Joon Hyuck Jang, Sanghyu Nam, Koeun Lee, Jin Kim, Jae Yong Kim, Hungwon Tchah & Hun Lee. (2022) Investigation of Prognostic Factors for Intense Pulsed Light Treatment with a Vascular Filter in Patients with Moderate or Severe Meibomian Gland Dysfunction. Journal of Clinical Medicine 11:16, pages 4724.
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Marie-Caroline Trone, Thibaud Garcin, Edouard Ollier, Gilles Thuret & Philippe Gain. (2022) A retrospective study of the efficacy of intense pulsed light delivered by the Lacrystim® for meibomian gland dysfunction therapy. BMC Ophthalmology 22:1.
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Shima Fukuoka & Reiko Arita. (2022) Comparison of Intense Pulsed Light Therapy on Patients with Meibomian Gland Dysfunction Using AQUA CEL and M22 Devices. Journal of Clinical Medicine 11:15, pages 4265.
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Rolando Toyos, Neel R. Desai, Melissa Toyos & Steven J. Dell. (2022) Intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction: A randomized controlled study. PLOS ONE 17:6, pages e0270268.
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Luoying Xie, Wenjing Song, Wenhui Dong, Yingsi Li, Shudi Chen, Xiaona Sun, Meiting Huang, Yu Cheng, Yuan Gao, Songlin Yang & Xiaoming Yan. (2022) Indirect Application of Intense Pulsed Light Induces Therapeutic Effects on Experimental Murine Meibomian Gland Dysfunction. Frontiers in Medicine 9.
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Jung Yeob Han, Yunhan Lee, Sanghyu Nam, Su Young Moon, Hun Lee, Jae Yong Kim & Hungwon Tchah. (2022) Effect of intense pulsed light using acne filter on eyelid margin telangiectasia in moderate-to-severe meibomian gland dysfunction. Lasers in Medical Science 37:4, pages 2185-2192.
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Zimeng Zhai, Hao Jiang, Yuqing Wu, Pei Yang, Shuyun Zhou & Jiaxu Hong. (2022) Safety and Feasibility of Low Fluence Intense Pulsed Light for Treating Pediatric Patients with Moderate-to-Severe Blepharitis. Journal of Clinical Medicine 11:11, pages 3080.
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Gengxi Lu, Sumanth Gollapudi, Runze Li, Margaret L Pfeiffer, Preeya Mehta, Laiming Jiang, Sarah Hamm-Alvarez, Mark Humayun, Qifa Zhou & Sandy X Zhang-Nunes. (2021) Focused ultrasound stimulation on meibomian glands for the treatment of evaporative dry eye. Experimental Biology and Medicine 247:6, pages 519-526.
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Yaying Wu, Yujie Mou, Yu Zhang, Yu Han, Lin Lin, Yanan Huo, Yirui Zhu, Shuo Yang & Xiaodan Huang. (2022) Efficacy of Intense Pulsed Light Combined Blood Extract Eye Drops for Treatment of Nociceptive Pain in Dry Eye Patients. Journal of Clinical Medicine 11:5, pages 1312.
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Sana Niazi & Farideh Doroodgar. 2022. Dry Eye Syndrome - Modern Diagnostic Techniques and Advanced Treatments. Dry Eye Syndrome - Modern Diagnostic Techniques and Advanced Treatments.
Mauricio Aguirre Baez & Rodrigo Castillo Iturria. 2022. Dry Eye Syndrome - Modern Diagnostic Techniques and Advanced Treatments. Dry Eye Syndrome - Modern Diagnostic Techniques and Advanced Treatments.
Gaspare Monaco & Giuseppe Casalino. (2020) Superficial keratectomy followed by intense pulsed light for Salzmann’s nodular degeneration and coexisting meibomian gland dysfunction. European Journal of Ophthalmology 32:1, pages NP27-NP30.
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T. Naudin, D. Thorel, F. Tétart, M. Muraine & J. Gueudry. (2021) Traitement combiné par lumière intense pulsée et thérapie par lumière de faible niveau dans le dysfonctionnement des glandes de Meibomius. Journal Français d'Ophtalmologie 44:7, pages 1021-1028.
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María T. Iradier, María Ángeles del Buey, Cristina Peris-Martínez, Priscilla Cedano & David P. Piñero. (2021) Characterization and Prediction of the Clinical Outcome of Intense Pulsed Light-Based Treatment in Dry Eye Associated to Meibomian Gland Dysfunction. Journal of Clinical Medicine 10:16, pages 3573.
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Matteo Di Marino, Paola Conigliaro, Francesco Aiello, Claudia Valeri, Clarissa Giannini, Raffaele Mancino, Stella Modica, Carlo Nucci, Roberto Perricone & Massimo Cesareo. (2021) Combined Low-Level Light Therapy and Intense Pulsed Light Therapy for the Treatment of Dry Eye in Patients with Sjögren’s Syndrome. Journal of Ophthalmology 2021, pages 1-6.
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Kerry Heitmiller, Christina Ring, Nazanin Saedi & Brian Biesman. (2021) Nonsurgical Light and Energy–Based Devices. Facial Plastic Surgery Clinics of North America 29:2, pages 323-334.
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Carlos Vergés, José Salgado-Borges & Francesc March de Ribot. (2021) Prospective evaluation of a new intense pulsed light, thermaeye plus, in the treatment of dry eye disease due to meibomian gland dysfunction. Journal of Optometry 14:2, pages 103-113.
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Kyoung Yoon Shin, Dong Hui Lim, Chan Hee Moon, Byung Jin Kim & Tae-Young Chung. (2021) Intense pulsed light plus meibomian gland expression versus intense pulsed light alone for meibomian gland dysfunction: A randomized crossover study. PLOS ONE 16:3, pages e0246245.
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S. Egri, I. Van Hollebecke, D. Guindolet, C. Manenti, H. Rougier, É. Gabison, I. Cochereau & S. Doan. (2021) Efficacité de la lumière pulsée dans le traitement des sécheresses oculaires sévères par dysfonctionnement meibomien. Journal Français d'Ophtalmologie 44:2, pages 169-175.
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Siamak Zarei-Ghanavati, Samira Hassanzadeh, AbbasAzimi Khorasani & Asieh Ehsaei. (2021) The effect of meibomian gland dysfunction treatment on sleep quality. Journal of Current Ophthalmology 33:3, pages 272.
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Xiaoming Yan, Jing Hong, Xiuming Jin, Wei Chen, Bei Rong, Yun Feng, Xiaodan Huang, Jinyang Li, Wenjing Song, Lin Lin & Yu Cheng. (2021) The Efficacy of Intense Pulsed Light Combined With Meibomian Gland Expression for the Treatment of Dry Eye Disease Due to Meibomian Gland Dysfunction: A Multicenter, Randomized Controlled Trial. Eye & Contact Lens: Science & Clinical Practice 47:1, pages 45-53.
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Xiangjie Leng, Meirong Shi, Xinyu Liu, Jingzhe Cui, Huaping Sun & Xuejing Lu. (2020) Intense pulsed light for meibomian gland dysfunction: a systematic review and meta-analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 259:1, pages 1-10.
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Reiko Arita, Shima Fukuoka, Takanori Mizoguchi & Naoyuki Morishige. (2020) Multicenter Study of Intense Pulsed Light for Patients with Refractory Aqueous-Deficient Dry Eye Accompanied by Mild Meibomian Gland Dysfunction. Journal of Clinical Medicine 9:11, pages 3467.
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Behzod Tashbayev, Mazyar Yazdani, Reiko Arita, Fredrik Fineide & Tor Paaske Utheim. (2020) Intense pulsed light treatment in meibomian gland dysfunction: A concise review. The Ocular Surface 18:4, pages 583-594.
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Edward J. Wladis, Vinay K. Aakalu, Jill A. Foster, Suzanne K. Freitag, Rachel K. Sobel, Jeremiah P. Tao & Michael T. Yen. (2020) Intense Pulsed Light for Meibomian Gland Disease. Ophthalmology 127:9, pages 1227-1233.
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Harvey A. FishmanLaura M. PerimanAmi A. Shah. (2020) Real-Time Video Microscopy of In Vitro Demodex Death by Intense Pulsed Light . Photobiomodulation, Photomedicine, and Laser Surgery 38:8, pages 472-476.
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Aria Vazirnia, Heidi Wat, Melissa J. Danesh & R. Rox Anderson. (2020) Intense pulsed light for improving dry eye disease in rosacea. Journal of the American Academy of Dermatology 83:2, pages e105.
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Yue Wu, Junhua Li, Man Hu, Yinying Zhao, Xiaolei Lin, Yiqin Chen, Lu Li & Yun-e Zhao. (2020) Comparison of two intense pulsed light patterns for treating patients with meibomian gland dysfunction. International Ophthalmology 40:7, pages 1695-1705.
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Raman-Deep Singh Sambhi, Gagan Deep Singh Sambhi, Rookaya Mather & Monali S. Malvankar-Mehta. (2020) Intense pulsed light therapy with meibomian gland expression for dry eye disease. Canadian Journal of Ophthalmology 55:3, pages 189-198.
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Serap Yurttaser Ocak, Sezen Karakus, Osman Bulut Ocak, Akın Cakir, Selim Bolukbasi, Burak Erden, Emine Bas & Mustafa Elcioglu. (2020) Intense pulse light therapy treatment for refractory dry eye disease due to meibomian gland dysfunction. International Ophthalmology 40:5, pages 1135-1141.
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Shanshan Wei, Xiaotong Ren, Yuexin Wang, Yilin Chou & Xuemin Li. (2020) Therapeutic Effect of Intense Pulsed Light (IPL) Combined with Meibomian Gland Expression (MGX) on Meibomian Gland Dysfunction (MGD). Journal of Ophthalmology 2020, pages 1-7.
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Andrew Matheson. (2020) IPL photo-biomodulation for optometrists. Optician 2020:4, pages 8244-1.
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Ally L. Xue, Michael T.M. Wang, Susan E. Ormonde & Jennifer P. Craig. (2020) Randomised double-masked placebo-controlled trial of the cumulative treatment efficacy profile of intense pulsed light therapy for meibomian gland dysfunction. The Ocular Surface 18:2, pages 286-297.
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Sharlotta Cote, Alexis Ceecee Zhang, Victoria Ahmadzai, Amina Maleken, Christine Li, Jeremy Oppedisano, Kaavya Nair, Ljoudmila Busija & Laura E Downie. (2020) Intense pulsed light (IPL) therapy for the treatment of meibomian gland dysfunction. Cochrane Database of Systematic Reviews 2020:3.
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Tenna Stefania, Turco Piergiorgio, Brunetti Beniamino, Antonio Di Zazzo, Macchi Jacopo, Bonini Stefano & Persichetti Paolo. (2019) The role of intense pulsed light (IPL) in the treatment of meibomian gland dysfunction (MGD). European Journal of Plastic Surgery 42:6, pages 563-568.
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Sheng-nan Cheng, Fa-gang Jiang, Hua Chen, Hui Gao & Yu-kan Huang. (2019) Intense Pulsed Light Therapy for Patients with Meibomian Gland Dysfunction and Ocular Demodex Infestation. Current Medical Science 39:5, pages 800-809.
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