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Review

Macular edema associated with non-infectious uveitis: pathophysiology, etiology, prevalence, impact and management challenges

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Pages 1761-1777 | Published online: 10 Sep 2019

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Alexandra Bograd, Dominic Fuchs, Josephin Bächtiger, Isabel B. Pfister, Jan Spindler, Florence Hoogewoud, Konstantin Gugleta, Christian Böni, Yan Guex-Crosier, Justus G. Garweg & Christoph Tappeiner. (2023) Long-term Efficacy of TNF-alpha Inhibitors on Persistent Uveitic Macular Edema: A Swiss Multicenter Cohort Study. Ocular Immunology and Inflammation 31:5, pages 981-988.
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Yu-Jang Chao, Jia-Horung Hung, Chang-Ping Lin, Hsi-Kung Kuo, San-Ni Chen, Yih-Shiou Hwang, Ko-Jen Li, Chun-Ju Lin, De-Kuang Hwang & Shwu-Jiuan Sheu. (2023) Diagnosis, Treatment, and Prevention of Noninfectious Acute Anterior Uveitis with or without Human Leukocyte Antigen B27 in Adults - Expert Consensus in Taiwan. Ocular Immunology and Inflammation 0:0, pages 1-8.
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Adrian T Babel, Eric K Chin & David RP Almeida. (2022) Long-Acting Fluocinolone Acetonide Intravitreal Implant for Recurrent Bilateral Non-Infectious Posterior Uveitis. International Medical Case Reports Journal 15, pages 665-669.
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Joanne Thomas, Lucas Kim, Thomas Albini & Steven Yeh. (2022) Triamcinolone acetonide injectable suspension for suprachoroidal use in the treatment of macular edema associated with uveitis. Expert Review of Ophthalmology 17:3, pages 165-173.
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Articles from other publishers (24)

Kelly Corbitt & Johannes Nowatzky. (2023) Inflammatory eye disease for rheumatologists. Current Opinion in Rheumatology 35:3, pages 201-212.
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Natalia I. Khramenko, Natalia V. Konovalova, Volodymyr Ya. Usov, Liudmyla M. Velychko & Olexandra V. Bogdanova. (2022) Immunity status and expression of molecular markers (ICAM-1, CD5, CD25, CD95) on lymphocytes of patients with recurrent anterior uveitis complicated by macular edema. Graefe's Archive for Clinical and Experimental Ophthalmology 261:5, pages 1423-1431.
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Argyrios Chronopoulos, Panagiotis Chronopoulos, L.O. Hattenbach, Agharza Ashurov, James S. Schutz, Norbert Pfeiffer & Christina Korb. (2022) Intravitreal fluocinolone acetonide implant for chronic postoperative cystoid macular edema – two years results. European Journal of Ophthalmology 33:2, pages 1054-1060.
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Sivaraman Balamurugan & Anjana Somanath. (2022) Commentary: Topical interferon: A novel approach to uveitic macula edema. Indian Journal of Ophthalmology 70:12, pages 4361-4363.
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Munirah Alafaleq, Romain Freund, Marie-Aude Penet, Christine Fardeau, Corinne Isnard-Bagnis, Sophie Tezenas du Montcel, Gilbert Deray, Phuc LE Hoang, Bahram Bodaghi & Isabelle Tostivint. (2021) Ciclosporin A in bilateral auto-immune chronic posterior uveitis associated with macular oedema: a Long-term Observational Safety and Efficacy Study. Eye 36:11, pages 2144-2150.
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Frauke Stascheit, Anne Rübsam, Carolin Otto, Andreas Meisel, Klemens Ruprecht & Uwe Pleyer. (2022) Anti‐CD20 therapy for multiple sclerosis‐associated uveitis: A case series . European Journal of Neurology 29:10, pages 3028-3038.
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Jie Zhang, Hui YanJing LiBing Li. (2022) Aqueous Humor Factors' Predictive Effects in Treating Refractor Macular Edema: An Overview. Journal of Interferon & Cytokine Research 42:10, pages 515-524.
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Subrata Bhattacharyya, Seenu M. Hariprasad, Thomas A. Albini, Sekhar K. Dutta, Denny John, William V. Padula, David Harrison & George Joseph. (2022) Suprachoroidal Injection of Triamcinolone Acetonide Injectable Suspension for the Treatment of Macular Edema Associated With Uveitis in the United States: A Cost-Effectiveness Analysis. Value in Health 25:10, pages 1705-1716.
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Omar Mohammad Ismail & Christopher R. Henry. (2022) An Update on Suprachoroidal Corticosteroid Injections in the Management of Macular Edema. Current Ophthalmology Reports 10:3, pages 91-97.
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Pia Allegri, Sara Olivari, Federico Rissotto & Roberta Rissotto. (2022) Sarcoid Uveitis: An Intriguing Challenger. Medicina 58:7, pages 898.
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Mathilde Leclercq, Anaïs Andrillon, Georgina Maalouf, Pascal Sève, Philip Bielefeld, Julie Gueudry, Thomas Sené, Thomas Moulinet, Bénédicte Rouvière, Damien Sène, Anne-Claire Desbois, Fanny Domont, Sara Touhami, Carolla El Chamieh, Patrice Cacoub, Bahram Bodaghi, Lucie Biard & David Saadoun. (2022) Anti–Tumor Necrosis Factor α versus Tocilizumab in the Treatment of Refractory Uveitic Macular Edema. Ophthalmology 129:5, pages 520-529.
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Atsunobu Takeda, Eiichi Hasegawa, Nobuyo Yawata, Shoji Notomi, Keijiro Ishikawa, Yusuke Murakami, Toshio Hisatomi, Kazuhiro Kimura & Koh-Hei Sonoda. (2022) Increased vitreous levels of B cell activation factor (BAFF) and soluble interleukin-6 receptor in patients with macular edema due to uveitis related to Behçet’s disease and sarcoidosis. Graefe's Archive for Clinical and Experimental Ophthalmology.
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Heather G Mack, Mark Hassall, Anthony J H Hall, Matthew P Simunovic, Samantha Fraser-Bell & Lauren N Ayton. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 693 731 .
Christine Fardeau, Mehdi Bencheqroun, Arielle Levy, Sophie Bonnin, Marie-Adélaïde Ferchaud, Leila Fardeau, Florence Coscas, Bahram Bodaghi & Bénédicte Lebrun-Vignes. (2021) Uveitis associated with cancer immunotherapy: long-term outcomes. Immunotherapy 13:18, pages 1465-1481.
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Anh Hong Nguyen, Bethlehem Mekonnen, Eric Kim & Nisha R. Acharya. (2021) Clinical outcomes of pediatric macular edema associated with non-infectious uveitis. Journal of Ophthalmic Inflammation and Infection 11:1.
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Seenu M Hariprasad, George Joseph, Patrick Gagnon-Sanschagrin, Elizabeth Serra, Subrata Bhattacharyya, Jérôme Bédard, Annie Guérin & Thomas Arno Albini. (2021) Healthcare costs among patients with macular oedema associated with non-infectious uveitis: a US commercial payer’s perspective. BMJ Open Ophthalmology 6:1, pages e000896.
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Slawomir Jan Teper. (2021) Update on the Management of Uveitic Macular Edema. Journal of Clinical Medicine 10:18, pages 4133.
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Marc Figueras-Roca, Jessica Matas, Víctor Llorens, Anna Sala-Puigdollers, Manuel Navarro, Javier Zarranz-Ventura, Alfredo Adán & Blanca Molins. (2021) Systemic contribution of inflammatory mediators to the severity of diabetic and uveitic macular edema. Graefe's Archive for Clinical and Experimental Ophthalmology 259:9, pages 2695-2705.
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L. Rodríguez Vicente, E. Martín-García, J.J. Chavarri-García, B. Jiménez-Del Río, I. Ortega-Renedo, A. Ibañez-Muñoz & J.L. Del Río-Mayor. (2021) Cystoid macular edema refractory to treatment. Journal Français d'Ophtalmologie 44:4, pages e211-e213.
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Maximilian W.M. Wintergerst, Xiaoxuan Liu, Jan H. Terheyden, Dominika Pohlmann, Jeany Q. Li, Giovanni Montesano, Giovanni Ometto, Frank G. Holz, David P. Crabb, Uwe Pleyer, Carsten Heinz, Alastair K. Denniston & Robert P. Finger. (2021) Structural Endpoints and Outcome Measures in Uveitis. Ophthalmologica 244:5, pages 465-479.
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Н.И. Храменко. (2020) Etiology and Pathogenesis of Macular Edema in Anterior Uveitis (Review). Офтальмология. Восточная Европа:3, pages 361-369.
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Vittorio Pirani, Paolo Pelliccioni, Serena De Turris, Alessandro Rosati, Alessandro Franceschi, Pierangelo Pasanisi, Rosaria Gesuita, Michele Nicolai & Cesare Mariotti. (2020) Intraocular Inflammation Control and Changes in Retinal and Choroidal Architecture in Refractory Non-Infectious Uveitis Patients after Adalimumab Therapy. Journal of Clinical Medicine 9:2, pages 510.
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Georgios D Panos. (2020) Advances in intravitreal therapy and implants: where are we now?. Therapeutic Delivery 11:2, pages 69-73.
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Kenneth W Price, Thomas A Albini & Steven Yeh. (2020) Suprachoroidal Injection of Triamcinolone—Review of a Novel Treatment for Macular Edema Caused by Noninfectious Uveitis. US Ophthalmic Review 13:2, pages 76.
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