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Review

Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis

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Pages 1973-1980 | Published online: 07 Oct 2019

Keep up to date with the latest research on this topic with citation updates for this article.

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Thomas H. Dohlman, Rohan Bir Singh & Reza Dana. (2021) Advances in the Medical Management of Neurotrophic Keratitis. Seminars in Ophthalmology 36:4, pages 335-340.
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Xi Dai, Adrianna Jensen, Chen Dun, Sezen Karakus, Fatemeh Rajaii & Fasika Woreta. (2023) Cost and Prescriber and Patient Characteristics of Cenegermin Use in the Medicare Population. American Journal of Ophthalmology 250, pages 12-19.
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Zanna Kruoch, Darren SJ Ting, Paul McCann, Andrew Kemp, Marcus Gonzales & Irene C Kuo. (2023) Medical and surgical interventions for neurotrophic keratopathy. Cochrane Database of Systematic Reviews 2023:2.
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Abdelrahman M. Elhusseiny, Aisha S. Traish, Hajirah N. Saeed & Iason S. Mantagos. (2022) Topical cenegermin 0.002% for pediatric neurotrophic keratopathy. European Journal of Ophthalmology 32:6, pages 3420-3424.
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M.H. Le Nguyen, M.S Naoum, C. Andre, L. Lethier, S. Limat, C. Fagnoni-Legat, Y. Guillaume & A.S. Gauthier. (2022) Physicochemical and microbiological stability of insulin eye drops in an artificial tear vehicle used in the treatment of refractory neurotrophic keratopathy. Journal Français d'Ophtalmologie 45:8, pages 860-871.
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Sebnem Kaya Ergen, Sevgi Subasi, Selenay Furat Rencber, Gökhan Duruksu & Yusufhan Yazir. (2022) Evaluation of clinical and histological effects of KGF-2 and NGF on corneal wound healing in an experimental alkali burn rabbit model. Experimental Eye Research 223, pages 109190.
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Sara Fatima Syed, Andrew Marshall, Parwez Hossain & Saghir Ahmed Sadiq. (2022) Blink Reflex in Neurotrophic Keratopathy: An Electrophysiological Evaluation. Ophthalmic Plastic & Reconstructive Surgery 38:5, pages 433-437.
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Alice T. Epitropoulos & Jamie L. Weiss. (2022) Topical human recombinant nerve growth factor for stage 1 Neurotrophic Keratitis: Retrospective case series of cenegermin treatment. American Journal of Ophthalmology Case Reports 27, pages 101649.
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Fang Zeng, Sha Liao, Zhe Kuang, Qingchun Zhu, Hengxi Wei, Junsong Shi, Enqin Zheng, Zheng Xu, Sixiu Huang, Linjun Hong, Ting Gu, Jie Yang, Huaqiang Yang, Gengyuan Cai, Stefan Moisyadi, Johann Urschitz, Zicong Li & Zhenfang Wu. (2022) Genetically Engineered Pigs as Efficient Salivary Gland Bioreactors for Production of Therapeutically Valuable Human Nerve Growth Factor. Cells 11:15, pages 2378.
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Fu-shin X. Yu, Patrick S.Y. Lee, Lingling Yang, Nan Gao, Yangyang Zhang, Alexander V. Ljubimov, Ellen Yang, Qingjun Zhou & Lixin Xie. (2022) The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas. Progress in Retinal and Eye Research 89, pages 101039.
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Ruojing Huang, Caiying Su, Lvjie Fang, Jiaqi Lu, Jiansu Chen & Yong Ding. (2022) Dry eye syndrome: comprehensive etiologies and recent clinical trials. International Ophthalmology 42:10, pages 3253-3272.
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Leandro Inferrera, Emanuela Aragona, Adam Wylęgała, Antonio Valastro, Gianluigi Latino, Elisa I. Postorino, Romana Gargano, Bogusława Orzechowska-Wylęgała, Edward Wylęgała & Anna M. Roszkowska. (2022) The Role of Hi-Tech Devices in Assessment of Corneal Healing in Patients with Neurotrophic Keratopathy. Journal of Clinical Medicine 11:6, pages 1602.
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Sébastien Roumeau, Frédéric Dutheil, Vincent Sapin, Julien S. Baker, Stephanie L. Watson, Bruno Pereira, Frédéric Chiambaretta & Valentin Navel. (2022) Efficacy of treatments for neurotrophic keratopathy: a systematic review and meta-analysis. Graefe's Archive for Clinical and Experimental Ophthalmology.
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Anubha Rathi, Nandini Bothra, SmrutiR Priyadarshini, DivyaS R Achanta, Merle Fernandes, SomasheilaI Murthy, AnasuaG Kapoor, TarjaniV Dave, Suryasnata Rath, Rajesh Yellinedi, Rambabu Nuvvula, Gautam Dendukuri, MilindN Naik & Muralidhar Ramappa. (2022) Neurotization of the human cornea – A comprehensive review and an interim report. Indian Journal of Ophthalmology 70:6, pages 1905.
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Nicole Weber Duncan, Kourtney H Houser & Sumitra S Khandelwal. (2022) Neurotrophic Keratitis: A Review. US Ophthalmic Review 16:2, pages 67.
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V.V. Brzheskiy, V.Yu. Popov, E.L. Efimova & S.Yu. Golubev. (2022) Modern capabilities in diagnosis and treatment of neurotrophic keratopathy. Vestnik oftal'mologii 138:6, pages 123.
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Alejandro Arboleda & Christopher N. Ta. (2022) Observational study of cenegermin for the treatment of limbal stem cell deficiency associated with neurotrophic keratopathy. Therapeutic Advances in Ophthalmology 14, pages 251584142211345.
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Helio V. Neves da Silva, John Placide, Anne Duong, Yasmyne Ronquillo, Shannon McCabe & Majid Moshirfar. (2022) Ocular adverse effects of therapeutic biologics. Therapeutic Advances in Ophthalmology 14, pages 251584142110708.
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Sana Qureshi, Tanner J. Ferguson, Mira Lim, Jae Young You, Jeffrey M. Goshe & Christopher T. Hood. (2022) Acute Calcific Band Keratopathy as an Adverse Effect of Recombinant Human Nerve Growth Factor (Cenegermin): A Multicenter Case Series. Cornea 41:1, pages 52-59.
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Romina Mayra Lasagni Vitar, Paolo Rama & Giulio Ferrari. (2022) The two-faced effects of nerves and neuropeptides in corneal diseases. Progress in Retinal and Eye Research 86, pages 100974.
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L. Latta, F.C. Figueiredo, R. Ashery-Padan, J.M. Collinson, J. Daniels, S. Ferrari, N. Szentmáry, S. Solá, R. Shalom-Feuerstein, M. Lako, S. Xapelli, D. Aberdam & N. Lagali. (2021) Pathophysiology of aniridia-associated keratopathy: Developmental aspects and unanswered questions. The Ocular Surface 22, pages 245-266.
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Nick Zambino & Zeba A. Syed. (2021) Resolution of a neurotrophic keratopathy associated hypopyon with cenegermin. American Journal of Ophthalmology Case Reports 23, pages 101113.
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Rhiya Mittal, Sneh Patel & Anat Galor. (2021) Alternative therapies for dry eye disease. Current Opinion in Ophthalmology 32:4, pages 348-361.
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Jeremy B. Hatcher, Matias Soifer, Natalia G. Morales, Asim V. Farooq, Victor L. Perez & Christine Shieh. (2021) Aftermarket effects of cenegermin for neurotrophic keratopathy in pediatric patients. The Ocular Surface 21, pages 52-57.
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Larissa Gouvea, Raphael Penatti & Karolinne Maia Rocha. (2021) Neurotrophic keratitis after penetrating keratoplasty for lattice dystrophy. American Journal of Ophthalmology Case Reports 22, pages 101058.
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Erin S. Ong & Bennie H. Jeng. (2021) Current and future therapies for persistent corneal epithelial defects and neurotrophic keratopathy. Current Opinion in Ophthalmology 32:3, pages 262-267.
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Jane S. KimLeon RafailovIlya M. Leyngold. (2020) Corneal Neurotization for Postherpetic Neurotrophic Keratopathy: Initial Experience and Clinical Outcomes. Ophthalmic Plastic & Reconstructive Surgery 37:1, pages 42-50.
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Raul E. Ruiz-Lozano, Julio C. Hernandez-Camarena, Denise Loya-Garcia, Jesus Merayo-Lloves & Alejandro Rodriguez-Garcia. (2021) The molecular basis of neurotrophic keratopathy: Diagnostic and therapeutic implications. A review. The Ocular Surface 19, pages 224-240.
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Kristina Voss, Annie Nguyen & Martin Heur. (2021) Non-infectious and non-hereditary diseases of the corneal epithelium. Experimental Eye Research 202, pages 108316.
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Sneh Patel, Jodi Hwang, Divy Mehra & Anat Galor. (2021) Corneal Nerve Abnormalities in Ocular and Systemic Diseases. Experimental Eye Research 202, pages 108284.
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Sarah Barbara Zwingelberg, Björn O. Bachmann & Claus Cursiefen. (2020) Real Life Data on Efficacy and Safety of Topical NGF Eye Drops (Cenegermin). Klinische Monatsblätter für Augenheilkunde 237:12, pages 1455-1461.
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Abhimanyu S Ahuja, Frank W Bowden & Jerry L Robben. (2020) A Novel Treatment for Neurotrophic Corneal Ulcer Using Topical Cenegermin (OXERVATE™) Containing Recombinant Human Nerve Growth Factor. Cureus.
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Kosmas Papadopoulos, Volker Besgen & Walter Sekundo. (2020) Successful Treatment of a Pediatric Neurotrophic Keratopathy With Cenegermin. Cornea Publish Ahead of Print.
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Eric Weinlander, Jennifer Ling, Aparna Reddy & Nambi Nallasamy. (2020) Epithelial Plaque Formation Secondary to Recombinant Human Nerve Growth Factor. Cornea 39:9, pages 1174-1176.
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Emma D. Deeks & Yvette N. Lamb. (2020) Cenegermin: A Review in Neurotrophic Keratitis. Drugs 80:5, pages 489-494.
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