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Clinical Trial Report

Efficacy and safety of glycyrrhizin 2.5% eye drops in the treatment of moderate dry eye disease: results from a prospective, open-label pilot study

Carole Burillon1 Ophthalmology Department, University Hospital HCL, GH Edouard Herriot, Lyon, France, [email protected]Correspondence[email protected]

Frederic Chiambaretta2 Ophthalmology Department, Clermont-Ferrand University Hospital, Hôpital Gabriel Montpied, Clermont Ferrand, France

Pierre-Jean Pisella3 Ophthalmology Department, Paris Nord Val-de-Seine University Hospitals, Hôpital Bretonneau, Tours, France

Pages 2629-2636 | Published online: 14 Dec 2018

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Qiqi Li, Meng Xin, Xianggen Wu & Bo Lei. (2022) A nano-phytochemical ophthalmic solution for marked improvement of corneal wound healing in healthy or diabetic mice. Nanomedicine 17:3, pages 151-165.
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Mallika Somayajulu, Sharon A. McClellan, Denise A. Bessert, Ahalya Pitchaikannu & Linda D. Hazlett. (2022) Ocular Effects of Glycyrrhizin at Acidic and Neutral pH. Frontiers in Cellular and Infection Microbiology 11.
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Dipak Kumar Sahu, Deepak Pradhan, Prativa Biswasroy, Biswakanth Kar, Goutam Ghosh & Goutam Rath. (2021) Recent trends in nanocarrier based approach in the management of dry eye disease. Journal of Drug Delivery Science and Technology 66, pages 102868.
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Qiqi Li, Xianggen Wu & Meng Xin. (2021) Strengthened rebamipide ocular nanoformulation to effectively treat corneal alkali burns in mice through the HMGB1 signaling pathway. Experimental Eye Research 213, pages 108824.
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Qiqi Li, Xiaoming Wu, Shanshan Xin, Xianggen Wu & Jie Lan. (2021) Preparation and characterization of a naringenin solubilizing glycyrrhizin nanomicelle ophthalmic solution for experimental dry eye disease. European Journal of Pharmaceutical Sciences 167, pages 106020.
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Alyce Alven, Carolina Lema & Rachel L. Redfern. (2021) Impact of Low Humidity on Damage-associated Molecular Patterns at the Ocular Surface during Dry Eye Disease. Optometry and Vision Science 98:11, pages 1231-1238.
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Valentina Citi, Fabio Neggiani, Marco Sansò & Vincenzo Calderone. (2021) Pharmacological evaluation of innovative eye drop formulations containing TS-polysaccaride, hyaluronic acid and glycyrrhizin for irritative ocular diseases using in vitro reconstituted human corneal epithelium model. Toxicology in Vitro 75, pages 105199.
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Yuzhen Hou, Meng Xin, Qiqi Li & Xianggen Wu. (2021) Glycyrrhizin micelle as a genistein nanocarrier: Synergistically promoting corneal epithelial wound healing through blockage of the HMGB1 signaling pathway in diabetic mice. Experimental Eye Research 204, pages 108454.
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Mallika SomayajuluSharon A. McClellanAhalya PitchaikannuDenise BessertLi LiuJena SteinleLinda D. Hazlett. (2021) Effects of Glycyrrhizin Treatment on Diabetic Cornea. Journal of Ocular Pharmacology and Therapeutics 37:1, pages 12-23.
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Yuzhen Hou, Jie Lan, Fan Zhang & Xianggen Wu. (2021) Expression profiles and potential corneal epithelial wound healing regulation targets of high-mobility group box 1 in diabetic mice. Experimental Eye Research 202, pages 108364.
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Kaichao Song, Meixing Yan, Mengshuang Li, Yiwan Geng & Xianggen Wu. (2020) Preparation and in vitro–in vivo evaluation of novel ocular nanomicelle formulation of thymol based on glycyrrhizin. Colloids and Surfaces B: Biointerfaces 194, pages 111157.
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Efficacy and safety of glycyrrhizin 2.5% eye drops in the treatment of moderate dry eye disease: results from a prospective, open-label pilot study

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Efficacy and safety of glycyrrhizin 2.5% eye drops in the treatment of moderate dry eye disease: results from a prospective, open-label pilot study

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