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Review

Herpes simplex keratitis: challenges in diagnosis and clinical management

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Pages 185-191 | Published online: 19 Jan 2017

Keep up to date with the latest research on this topic with citation updates for this article.

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Ian McCormick, Charlotte James, Nicky J Welton, Philippe Mayaud, Katherine M. E Turner, Sami L Gottlieb, Allen Foster & Katharine J Looker. (2022) INCIDENCE OF HERPES SIMPLEX VIRUS KERATITIS AND OTHER OCULAR DISEASE: GLOBAL REVIEW AND ESTIMATES. Ophthalmic Epidemiology 29:4, pages 353-362.
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Mohammad Abolhosseini, Seyed Mohamadmehdi Moshtaghion, Mozhgan Rezaei Kanavi & Seyed Bagher Hosseini. (2022) A triad of microscopes for rapid and proper diagnosis of infectious keratitis. Clinical and Experimental Optometry 105:3, pages 333-335.
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Sana Arshad, Constantinos Petsoglou, Taehwan Lee, Abdullah Al-Tamimi & Nicole A. Carnt. (2021) Twenty years since the Herpetic Eye Disease Study: Lessons, developments and applications to clinical practice. Clinical and Experimental Optometry 104:3, pages 396-405.
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Kuo-Hsuan Hung, Yu-Hsiang Lan, Jui-Yen Lin, Eugene Yu-Chuan Kang, Hsin-Yuan Tan, Hung-Chi Chen, Ching-Hsi Hsiao & Lung-Kun Yeh. (2020) Potential Role and Significance of Ocular Demodicosis in Patients with Concomitant Refractory Herpetic Keratitis. Clinical Ophthalmology 14, pages 4469-4482.
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Hui Zheng, Ye Liu, Dan Xu, Pingping Liu, Xiuxia Yang, Bing Li, Zimu Cao, Yang Liu & Xiaoshuo Zheng. (2020) Inhibition of Gap Junction–Mediated Intercellular Communication by Poly(I:C) in Cultured Human Corneal Fibroblasts. Current Eye Research 45:9, pages 1043-1050.
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Souska Zandi, Bahram Bodaghi & Justus G. Garweg. (2018) Review for Disease of the Year: Treatment of Viral Anterior Uveitis: A Perspective. Ocular Immunology and Inflammation 26:7, pages 1135-1142.
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Articles from other publishers (75)

Ruknesvary Subramaniam, Khairy Shamel Sonny Teo & Julieana Muhammed. (2023) Atypical Presentation of Herpes Stromal Keratitis in a Contact Lens Wearer. Cureus.
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Amrita Mohanty, Himansu Sekhar Behera, Manas Ranjan Barik, Amanjot Kaur, Savitri Sharma, Sujata Das, Merle Fernandes, Sailendra Panda & Srikant K Sahu. (2023) Microsporidia-induced stromal keratitis: a new cause of presumed immune stromal (interstitial) keratitis. British Journal of Ophthalmology 107:5, pages 607-613.
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Rahul K. Suryawanshi, Chandrashekhar D. Patil, Alex AgelidisRaghuram Koganti, Tejabhiram Yadavalli, Joshua M. Ames, Hemant Borase & Deepak Shukla. (2023) Pathophysiology of reinfection by exogenous HSV-1 is driven by heparanase dysfunction. Science Advances 9:17.
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Federico Di Staso, Daria Rullo, Mariachiara Di Pippo, Silvio Di Staso & Solmaz Abdolrahimzadeh. (2023) Optical Diagnostics in Herpetic Keratitis. Photonics 10:4, pages 349.
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Jiayi Ren, Ferrin Antony, Barry T. Rouse & Amol Suryawanshi. (2023) Role of Innate Interferon Responses at the Ocular Surface in Herpes Simplex Virus-1-Induced Herpetic Stromal Keratitis. Pathogens 12:3, pages 437.
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John D. Nelson. 2023. 2023 Nelson’s Pediatric Antimicrobial Therapy. 2023 Nelson’s Pediatric Antimicrobial Therapy.
Jeremy Altman, Garrett Jones, Saleh Ahmed, Shruti Sharma & Ashok Sharma. (2023) Tear Film MicroRNAs as Potential Biomarkers: A Review. International Journal of Molecular Sciences 24:4, pages 3694.
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Bonnie He, Hamid Tavakoli, Mahyar Etminan, Shayan Shokoohi, Alfonso Iovieno & Sonia N. Yeung. (2022) Impact of the use of anti-glaucoma medications on the risk of herpetic keratitis recurrence. International Ophthalmology 43:5, pages 1559-1564.
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Bisant A. Labib & DeGaulle I. Chigbu. (2022) Clinical Management of Herpes Simplex Virus Keratitis. Diagnostics 12:10, pages 2368.
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Patricia Fortin, Tyler Wickas, Henry D. Perry, Peter Wawrzusin & Marcelle Morcos. (2022) Bell's palsy with Herpes simplex disciform keratitis: A case report. American Journal of Ophthalmology Case Reports 27, pages 101575.
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Stefania Cometa, Carla Zannella, Francesco Busto, Anna De Filippis, Gianluigi Franci, Massimiliano Galdiero & Elvira De Giglio. (2022) Natural Formulations Based on Olea europaea L. Fruit Extract for the Topical Treatment of HSV-1 Infections. Molecules 27:13, pages 4273.
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Maria Cabrera‐Aguas, Pauline Khoo & Stephanie L. Watson. (2022) Infectious keratitis: A review. Clinical & Experimental Ophthalmology 50:5, pages 543-562.
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Xiao-Tang Yin, Nicholas K. Baugnon, Rohini Krishnan, Chloe A. Potter, Sudha Yarlagadda, Tammie L. Keadle & Patrick M. Stuart. (2022) CD137 costimulation is associated with reduced herpetic stromal keratitis and with developing normal CD8+ T cells in trigeminal ganglia. Journal of General Virology 103:6.
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Stergios K Chaloulis, Georgios Mousteris & Konstantinos T Tsaousis. (2022) Incidence and Risk Factors of Bilateral Herpetic Keratitis: 2022 Update. Tropical Medicine and Infectious Disease 7:6, pages 92.
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Lyudmila Alimbarova, Anna Egorova, Olga Riabova, Natalia Monakhova & Vadim Makarov. (2022) A proof-of-concept study for the efficacy of dispirotripiperazine PDSTP in a rabbit model of herpes simplex epithelial keratitis. Antiviral Research 202, pages 105327.
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Y -E Tsai & T -H Weng. (2021) Dendritic epithelial keratitis in primary herpes simplex infection. QJM: An International Journal of Medicine 114:11, pages 820-821.
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Radhika Natarajan, HirenD Matai, Sundaresan Raman, Subham Kumar, Swetha Ravichandran, Samyuktha Swaminathan & JohnSahaya Rani Alex. (2022) Advances in the diagnosis of herpes simplex stromal necrotising keratitis: A feasibility study on deep learning approach. Indian Journal of Ophthalmology 70:9, pages 3279.
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Emily Greenan, Sophie Gallagher, Rana Khalil, Conor C. Murphy & Joan Ní Gabhann-Dromgoole. (2021) Advancing Our Understanding of Corneal Herpes Simplex Virus-1 Immune Evasion Mechanisms and Future Therapeutics. Viruses 13:9, pages 1856.
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Raul Alfaro Rangel, Sabine Lepper, Nóra Szentmáry, Achim Langenbucher & Berthold Seitz. (2021) Herpes Simplex Virus Keratitis in a University Tertiary Referral Centre – Clinical Features and Surgical Approaches. Klinische Monatsblätter für Augenheilkunde 238:09, pages 989-995.
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Maria Cabrera‐Aguas, Yves Kerdraon & Stephanie L. Watson. (2020) Diagnosis using polymerase chain reaction and outcomes in herpes simplex keratitis. Acta Ophthalmologica 99:5.
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Sixto M. LealJr.Jr., Kyle G. Rodino, W. Craig Fowler & Peter H. Gilligan. (2021) Practical Guidance for Clinical Microbiology Laboratories: Diagnosis of Ocular Infections. Clinical Microbiology Reviews 34:3.
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Stephanie Hiu Ling Poon, William Ho Lam Wong, Amy Cheuk Yin Lo, Hao Yuan, Chien-Fu Chen, Vishal Jhanji, Yau Kei Chan & Kendrick Co Shih. (2021) A systematic review on advances in diagnostics for herpes simplex keratitis. Survey of Ophthalmology 66:3, pages 514-530.
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Mehrdad Mohammadpour, Leyla Alizadeh, Mahmoud Jabbarvand Behrouz & Masoud Khorrami-Nejad. (2021) Quantitative real-time polymerase chain reaction analysis in herpes simplex virus keratitis with and without epithelial involvement. International Ophthalmology 41:5, pages 1807-1813.
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Raghuram Koganti, Tejabhiram Yadavalli, Raza Ali Naqvi, Deepak Shukla & Afsar R. Naqvi. (2021) Pathobiology and treatment of viral keratitis. Experimental Eye Research 205, pages 108483.
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Thomas R. O’Neil, Kevin Hu, Naomi R. Truong, Sana Arshad, Barbara L. Shacklett, Anthony L. Cunningham & Najla Nasr. (2021) The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection. Viruses 13:3, pages 359.
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Yong-Qiang Wang, Li Cai, Nan Zhang, Jing Zhang, Hai-Hong Wang & Wei Zhu. (2020) Protective effect of total flavonoids from Ixeris Sonchifolia on herpes simplex virus keratitis in mice. BMC Complementary Medicine and Therapies 20:1.
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Piotr Kanclerz & Jorge L. Alio. (2020) Ocular surgery after herpes simplex and herpes zoster keratitis. International Ophthalmology 40:12, pages 3599-3612.
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Hasan BAYHAN, Seray ASLAN & Bekir KÜÇÜK. (2020) Unilateral herpes keratiti olan hastaların bilateral oküler yüzey ve gözyaşı osmolaritesinin değerlendirilmesi. Bozok Tıp Dergisi.
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