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Original Research

Thymosin beta 4 ophthalmic solution for dry eye: a randomized, placebo-controlled, Phase II clinical trial conducted using the controlled adverse environment (CAE™) model

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Pages 877-884 | Published online: 20 May 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Giulia Coco, Giacomo Ambrosini, Silvia Poletti, Laura Antonia Meliante, Andrea Taloni, Vincenzo Scorcia & Giuseppe Giannaccare. (2023) Recent advances in drug treatments for dry eye disease. Expert Opinion on Pharmacotherapy 0:0, pages 1-21.
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Lauren Mason, Saad Jafri, Isabelle Dortonne & John D Sheppard$suffix/text()$suffix/text(). (2021) Emerging therapies for dry eye disease. Expert Opinion on Emerging Drugs 26:4, pages 401-413.
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Jimena Tatiana Carreno-Galeano, Thomas H. Dohlman, Stella Kim, Jia Yin & Reza Dana. (2021) A Review of Ocular Graft-versus-Host Disease: Pathophysiology, Clinical Presentation and Management. Ocular Immunology and Inflammation 29:6, pages 1190-1199.
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Kelly K. Nichols, David G. Evans & Paul M. Karpecki. (2021) A Comprehensive Review of the Clinical Trials Conducted for Dry Eye Disease and the Impact of the Vehicle Comparators in These Trials. Current Eye Research 46:5, pages 609-614.
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Gabriel Sosne. (2018) Thymosin beta 4 and the eye: the journey from bench to bedside. Expert Opinion on Biological Therapy 18:sup1, pages 99-104.
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Javier Moreno-Montañés, Anne-Marie Bleau & Ana Isabel Jimenez. (2018) Tivanisiran, a novel siRNA for the treatment of dry eye disease. Expert Opinion on Investigational Drugs 27:4, pages 421-426.
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Articles from other publishers (8)

Yuyuan Ying, Chen Lin, Nana Tao, Robert D. Hoffman, Dongling Shi, Zhijin Chen & Jianli Gao. (2023) Thymosin β4 and Actin: Binding Modes, Biological Functions and Clinical Applications. Current Protein & Peptide Science 24:1, pages 78-88.
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Jiawei Ling, Ben Chung-Lap Chan, Miranda Sin-Man Tsang, Xun Gao, Ping Chung Leung, Christopher Wai-Kei Lam, Jiang-Miao Hu & Chun Kwok Wong. (2022) Current Advances in Mechanisms and Treatment of Dry Eye Disease: Toward Anti-inflammatory and Immunomodulatory Therapy and Traditional Chinese Medicine. Frontiers in Medicine 8.
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Yuxin Wang, Thomas W. Carion, Abdul Shukkur Ebrahim, Gabriel Sosne & Elizabeth A. Berger. (2021) Adjunctive Thymosin Beta-4 Treatment Influences PMN Effector Cell Function during Pseudomonas aeruginosa-Induced Corneal Infection. Cells 10:12, pages 3579.
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Walter Cabri, Paolo Cantelmi, Dario Corbisiero, Tommaso Fantoni, Lucia Ferrazzano, Giulia Martelli, Alexia Mattellone & Alessandra Tolomelli. (2021) Therapeutic Peptides Targeting PPI in Clinical Development: Overview, Mechanism of Action and Perspectives. Frontiers in Molecular Biosciences 8.
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Youssof Eshac, Rachel L. Redfern & Vinay Kumar Aakalu. (2021) The Role of Endogenous Antimicrobial Peptides in Modulating Innate Immunity of the Ocular Surface in Dry Eye Diseases. International Journal of Molecular Sciences 22:2, pages 721.
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Rujun Jin, Ying Li, Lan Li, Dong Hwan Kim, Che Dong Yang, Han Sun Son, Jung Han Choi, Hyeon Jeong Yoon & Kyung Chul Yoon. (2020) Anti‑inflammatory effects of glycine thymosin�β4 eye drops in experimental dry eye. Biomedical Reports.
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Thomas Carion, Abdul Ebrahim, David Kracht, Aditya Agrawal, Eliisa Strand, Omar Kaddurah, Cody McWhirter, Gabriel Sosne & Elizabeth Berger. (2018) Thymosin Beta-4 and Ciprofloxacin Adjunctive Therapy Improves Pseudomonas aeruginosa-Induced Keratitis. Cells 7:10, pages 145.
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Mael Lever, Carsten Theiss, Gabriela Morosan-Puopolo & Beate Brand-Saberi. (2016) Thymosin β4 overexpression regulates neuron production and spatial distribution in the developing avian optic tectum. Histochemistry and Cell Biology 147:5, pages 555-564.
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