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Original Research

Arenobufagin activates p53 to trigger esophageal squamous cell carcinoma cell apoptosis in vitro and in vivo

Junhong Lv1 Thoracic Surgeons Department

Shaohuan Lin1 Thoracic Surgeons DepartmentCorrespondence[email protected]

Panli Peng2 Oncology No 2 Department, Guangdong No 2 Provincial People’s Hospital, Guangzhou

Changqing Cai2 Oncology No 2 Department, Guangdong No 2 Provincial People’s Hospital, Guangzhou

Jianming Deng1 Thoracic Surgeons Department

Mingzhi Wang1 Thoracic Surgeons Department

Xuejun Li1 Thoracic Surgeons Department

Rongsheng Lin3 Department of Oncology, Shunde Longjiang Hospital, Foshan

Yu Lin4 Department of Gastroenterology, Puning Overseas Chinese Hospital

Ailing Fang5 Galactophore Department, Puning Maternity and Child Care Hospital, Puning, People’s Republic of China

Qiling Li5 Galactophore Department, Puning Maternity and Child Care Hospital, Puning, People’s Republic of China

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Pages 1261-1267 | Published online: 28 Feb 2017

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Akmal M. Asrorov, Muzaffar Kayumov, Nurkhodja Mukhamedov, Ansor Yashinov, Ziyoda Mirakhmetova, Yongzhuo Huang, Abulimiti Yili, Haji Akber Aisa, Mugrajitdin Tashmukhamedov, Shavkat Salikhov & Sharafitdin Mirzaakhmedov. (2023) Toad venom bufadienolides and bufotoxins: An updated review. Drug Development Research 84:5, pages 815-838.
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Wenmin Tang, Yanming Zhang, Keli Yang, Jianjiang Ma, Lian Dong, Chen Wu, Rongxue Lv, Chuanhao Wang, Chuan Luo, Huojun Zhang, Zhenyuan Miao & Yuelin Wu. (2023) Discovery of Novel 3,11‐Bispeptide Ester Arenobufagin Derivatives with Potential in Vivo Antitumor Activity and Reduced Cardiotoxicity . Chemistry & Biodiversity 20:2.
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Ke Chen, Angling Li, Jian Wang, Dongchang Li, Xiaoshan Wang, Chengwei Liu & Zhengguang Wang. (2023) Arenobufagin causes ferroptosis in human gastric cancer cells by increasing rev-erbα expression. Journal of Traditional and Complementary Medicine 13:1, pages 72-80.
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Lijuan Zhao, Lingyu Han, Xiaolu Wei, Yanyan Zhou, Yanqiong Zhang, Nan Si, Hongjie Wang, Jian Yang, Baolin Bian & Haiyu Zhao. (2021) Toxicokinetics of Arenobufagin and its Cardiotoxicity Mechanism Exploration Based on Lipidomics and Proteomics Approaches in Rats. Frontiers in Pharmacology 12.
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Baobao Chen, Chuanhao Wang, Jianjiang Ma, Haijun Ma, Yuan Wang, Hui Zhang, Yazhao Zhu, Jianzhong Yao, Chuan Luo, Zhenyuan Miao & Yuelin Wu. (2021) Discovery of 3-peptide substituted arenobufagin derivatives as potent antitumor agents with low cardiotoxicity. Steroids 166, pages 108772.
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Jiaqi Xiao, Meixiang Gao, Bo Fei, Gang Huang & Qiang Diao. (2020) Nature-derived anticancer steroids outside cardica glycosides. Fitoterapia 147, pages 104757.
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Li-Juan Deng, Yong Li, Ming Qi, Jun-Shan Liu, Sheng Wang, Li-Jun Hu, Yu-He Lei, Ren-Wang Jiang, Wei-Min Chen, Qi Qi, Hai-Yan Tian, Wei-Li Han, Bao-Jian Wu, Jia-Xu Chen, Wen-Cai Ye & Dong-Mei Zhang. (2020) Molecular mechanisms of bufadienolides and their novel strategies for cancer treatment. European Journal of Pharmacology 887, pages 173379.
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Jun Kan, Haifu Huang, Zhangyu Jiang, Ruisheng Zhou, Shasha Bai, Caijie Liao, Jiancong Chen, Jun Dong, Yunlong Zhang, Jingzhi Zhang, Rong Zhang, Daihan Zhou & Enxin Zhang. (2020) Arenobufagin Promoted Oxidative Stress-Associated Mitochondrial Pathway Apoptosis in A549 Non-Small-Cell Lung Cancer Cell Line. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-11.
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Jiafu Wang, Xiang Xie & Yurong Sun. (2020) Time series expression pattern of key genes reveals the molecular process of esophageal cancer. Bioscience Reports 40:2.
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Yun Mao, Xi Peng, Peng Xue, Dianrong Lu, Linlu Li & Shijie Zhu. (2020) Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-13.
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Xiaolu Wei, Jian Yang, Yingqiu MaoHaiyu Zhao, Nan Si, Hongjie Wang & Baolin Bian. (2020) Arenobufagin Inhibits the Phosphatidylinositol 3-kinase/Protein Kinase B/Mammalian Target of Rapamycin Pathway and Induces Apoptosis and Autophagy in Pancreatic Cancer Cells. Pancreas 49:2, pages 261-272.
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Xiang Zhan, Huan Wu, Hong Wu, Rong Wang, Chuan Luo, Bo Gao, Zhiwu Chen & Qinglin Li. (2020) Metabolites from Bufo gargarizans (Cantor, 1842): A review of traditional uses, pharmacological activity, toxicity and quality control. Journal of Ethnopharmacology 246, pages 112178.
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Chien-shan Cheng, Jiaqiang Wang, Jie Chen, Kuei Ting Kuo, Jian Tang, Huifeng Gao, Lianyu Chen, Zhen Chen & Zhiqiang Meng. (2019) New therapeutic aspects of steroidal cardiac glycosides: the anticancer properties of Huachansu and its main active constituent Bufalin. Cancer Cell International 19:1.
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Yongzhi Lv. (2018) Research on Antineoplastic Mechanism of Natural Product Arenobufagin. IOP Conference Series: Earth and Environmental Science 199, pages 022051.
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Ji Qi, Abu Zulfiker, Chun Li, David Good & Ming Wei. (2018) The Development of Toad Toxins as Potential Therapeutic Agents. Toxins 10:8, pages 336.
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Yuanbo Cui, Wei Wu, Pengju Lv, Jianying Zhang, Bingqing Bai & Wei Cao. (2017) Down-regulation of long non-coding RNA ESCCAL_1 inhibits tumor growth of esophageal squamous cell carcinoma in a xenograft mouse model. Oncotarget 9:1, pages 783-790.
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Li Guo & Yanli Liang. (2017) Expression of PBMC apoptosis-related factors in patients with chronic hepatitis B and their relationships with clinical prognosis. Experimental and Therapeutic Medicine.
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Liang Ma, Yindi Zhu, Sheng Fang, Hongyan Long, Xiang Liu & Zi Liu. (2017) Arenobufagin Induces Apoptotic Cell Death in Human Non-Small-Cell Lung Cancer Cells via the Noxa-Related Pathway. Molecules 22:9, pages 1525.
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Arenobufagin activates p53 to trigger esophageal squamous cell carcinoma cell apoptosis in vitro and in vivo

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Arenobufagin activates p53 to trigger esophageal squamous cell carcinoma cell apoptosis in vitro and in vivo

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