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Case Report

Effective BRAF inhibitor vemurafenib therapy in a 2-year-old patient with sequentially diagnosed Langerhans cell histiocytosis and Erdheim–Chester disease

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Pages 521-526 | Published online: 24 Jan 2017

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Debabrata Mohapatra, Aditya Kumar Gupta, Partha Haldar, Jagdish Prasad Meena, Pranay Tanwar & Rachna Seth. (2023) Efficacy and safety of vemurafenib in Langerhans cell histiocytosis (LCH): A systematic review and meta-analysis. Pediatric Hematology and Oncology 40:1, pages 86-97.
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Articles from other publishers (30)

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Menelaos Kanakis, Petros Petrou, Giota Lourida & Ilias Georgalas. (2022) Erdheim-Chester disease: a comprehensive review from the ophthalmologic perspective. Survey of Ophthalmology 67:2, pages 388-410.
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Luis Carlos Salazar, Luz Ángela Moreno, Lina Eugenia Jaramillo & Edgar Vladimir Cabrera. (2021) Enfermedad de Erdheim-Chester: primer caso pediátrico reportado en Colombia. Biomédica 41:4, pages 615-624.
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S. Menzinger, S. Fraitag & S. Barète. (2021) Histiocitosis. EMC - Dermatología 55:1, pages 1-16.
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Suheyla Ocak, Zuhal Bayramoglu, Deniz Tugcu, Serap Karaman, Aysegul Unuvar & Zeynep Karakas. (2021) Mixed Langerhans Cell Histiocytosis and Erdheim-Chester Disease in a Girl: A Rare and Puzzling Diagnosis. Journal of Pediatric Hematology/Oncology 43:3, pages e375-e379.
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Fanélie Jouenne, Amira Benattia & Abdellatif Tazi. (2021) Mitogen-activating protein kinase pathway alterations in Langerhans cell histiocytosis. Current Opinion in Oncology 33:2, pages 101-109.
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Martin D. Hyrcza. 2021. Pediatric Head and Neck Textbook. Pediatric Head and Neck Textbook 83 97 .
Ozlem Tezol, Elvan Caglar Citak, Yavuz Selim Ayhan, Yuksel Balci, Zehra Pinar Koc & Yasemin Yuyucu Karabulut. (2020) Effective High-dose Interferon-α Therapy in a 13-Year-Old Girl With Erdheim-Chester Disease. Journal of Pediatric Hematology/Oncology 42:4, pages 326-331.
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Albert Roessner, Maria Smolle & Johannes Haybäck. (2020) Riesenzelltumor des KnochensGiant cell tumor of bone. Der Pathologe 41:2, pages 134-142.
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Huan Liu, Andrew R. Osterburg, Jennifer Flury, Zulma Swank, Dennis W. McGraw, Nishant Gupta, Kathryn A. Wikenheiser-Brokamp, Ashish Kumar, Abdellatif Tazi, Yoshikazu Inoue, Masaki Hirose, Francis X. McCormack & Michael T. Borchers. (2020) MAPK mutations and cigarette smoke promote the pathogenesis of pulmonary Langerhans cell histiocytosis. JCI Insight 5:4.
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Alexander Averyanov, Evgeniya Kogan, Victor Lesnyak, Olesya Danilevskaya & Igor E. Stepanyan. 2020. Difficult to Diagnose Rare Diffuse Lung Disease. Difficult to Diagnose Rare Diffuse Lung Disease 321 359 .
Olive S. Eckstein, Johannes Visser, Carlos Rodriguez-Galindo & Carl E. Allen. (2019) Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPK pathway inhibition. Blood 133:15, pages 1691-1694.
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Xiaolei Hao, Ruie Feng, Yalan Bi, Yuhan Liu, Chunde Li, Tao Lu & Yongji Tian. (2019) Dramatic efficacy of dabrafenib in Erdheim-Chester disease (ECD): a pediatric patient with multiple large intracranial ECD lesions hidden by refractory Langerhans cell histiocytosis. Journal of Neurosurgery: Pediatrics 23:1, pages 48-53.
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Norbert Neckel, Andrej Lissat, Arendt von Stackelberg, Nadine Thieme, Mohemed-Salim Doueiri, Birgit Spors, Benedicta Beck-Broichsitter, Max Heiland & Jan-Dirk Raguse. (2019) Primary oral manifestation of Langerhans cell histiocytosis refractory to conventional therapy but susceptible to BRAF-specific treatment: a case report and review of the literature. Therapeutic Advances in Medical Oncology 11, pages 175883591987801.
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Jiaoyang Cai, Xia Huang, Minzhi Yin, Ci Pan, Lili Song, Zhiyan Zhan, Jing Chen, Yijin Gao, Jingyan Tang, Yanxin Li & Shuhong Shen. (2019) A novel fusion gene PLEKHA6-NTRK3 in langerhans cell histiocytosis. International Journal of Cancer 144:1, pages 117-124.
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Hany I. Sakr, Kaila Buckley, Robert Baiocchi, Weiqiang John Zhao & Jessica A. Hemminger. (2018) Erdheim Chester disease in a patient with Burkitt lymphoma: a case report and review of literature. Diagnostic Pathology 13:1.
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Jaume Monmany, Esther Granell, Laura López & Pere Domingo. (2018) Resolved heart tamponade and controlled exophthalmos, facial pain and diabetes insipidus due to Erdheim-Chester disease. BMJ Case Reports, pages bcr-2018-225224.
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José Manuel Fernández Armenteros, Nuria Arco Huguet, Veronica Sanmartin Novell, Felip Vilardell Villellas, Ana Velasco Sanchez, Elisa Martró Català, Rosa Maria Martí Laborda & Xavier Soria Gili. (2018) Langerhans cell histiocytosis mimicking molluscum contagiosum: A case series. Pediatric Blood & Cancer 65:7, pages e27047.
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Noah A. Brown & Kojo S.J. Elenitoba-Johnson. (2018) Clinical implications of oncogenic mutations in pulmonary Langerhans cell histiocytosis. Current Opinion in Pulmonary Medicine 24:3, pages 281-286.
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Joon Pyo Hong, Won Ki Ahn, Joo Yeon Lim, Jo Eun Jung, Seung Min Hahn, Jung Woo Han & Chuhl Joo Lyu. (2018) A Case of Erdheim-Chester Disease Developed during Treatment of Leukemiain a Child. Clinical Pediatric Hematology-Oncology 25:1, pages 66-70.
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Regina Fölster-Holst. (2018) Differential diagnoses of diaper dermatitis. Pediatric Dermatology 35, pages s10-s18.
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Gary Tran, Thy N. Huynh & Amy S. Paller. (2018) Langerhans cell histiocytosis: A neoplastic disorder driven by Ras-ERK pathway mutations. Journal of the American Academy of Dermatology 78:3, pages 579-590.e4.
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Kathryn M. Wagner, Jacob J. Mandel, J. Clay Goodman, Shankar Gopinath & Akash J. Patel. (2018) Intracranial Erdheim-Chester Disease Mimicking Parafalcine Meningioma: Report of Two Cases and Review of the Literature. World Neurosurgery 110, pages 365-370.
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Hamza Hashmi, Drew Murray, John Greenwell, Marwan Shaikh, Soumit Basu & Maxwell Krem. (2018) A Rare Case of Erdheim-Chester Disease (Non-Langerhans Cell Histiocytosis) with Concurrent Langerhans Cell Histiocytosis: A Diagnostic and Therapeutic Challenge. Case Reports in Hematology 2018, pages 1-6.
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Zenggang Pan & Bette K Kleinschmidt-DeMasters. (2017) CNS Erdheim–Chester Disease: A Challenge to Diagnose. Journal of Neuropathology & Experimental Neurology 76:12, pages 986-996.
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. (2017) Vemurafenib. Reactions Weekly 1648:1, pages 295-295.
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