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OncoTargets and Therapy Volume 10, 2017 - Issue
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Original Research

A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway

Gang Wang1 Center for New Drug Research and Development, College of Life Science, Nanjing Normal University
,
Yue Jing2 Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University
,
Lingsen Cao3 Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, People’s Republic of China
,
Changchang Gong1 Center for New Drug Research and Development, College of Life Science, Nanjing Normal University
,
Zhunan Gong1 Center for New Drug Research and Development, College of Life Science, Nanjing Normal University;3 Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, People’s Republic of ChinaCorrespondence[email protected] [email protected]
&
Xiangrong Cao3 Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, People’s Republic of ChinaCorrespondence[email protected] [email protected]
Pages 55-66 | Published online: 20 Dec 2016

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Zarina Mushtaq, Muhammad Imran, Muzzamal Hussain, Farhan Saeed, Ali Imran, Maryam Umar, Mohamed A. Abdelgawad, Ahmed H. El-Ghorab, Awais Ahmed, Suliman A. Alsagaby, Mohamad Fawzi Mahomoodally & Entessar Al Jbawi. (2023) Asiatic acid: a review on its polypharmacological properties and therapeutic potential against various Maladies. International Journal of Food Properties 26:1, pages 1244-1263.
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Articles from other publishers (10)

Soubhagya Tripathy, Deepak Kumar Verma, Mamta Thakur, Nishant Chakravorty, Smita Singh & Prem Prakash Srivastav. (2022) Recent trends in extraction, identification and quantification methods of Centella asiatica phytochemicals with potential applications in food industry and therapeutic relevance: A review. Food Bioscience 49, pages 101864.
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Hongtao Luo, Zhen Yang, Qiuning Zhang, Lihua Shao, Shihong Wei, Ruifeng Liu, Zheng Li, Yichao Geng, Chengcheng Li & Xiaohu Wang. (2020) Carbon Ion Therapy Inhibits Esophageal Squamous Cell Carcinoma Metastasis by Upregulating STAT3 Through the JAK2/STAT3 Signaling Pathway. Frontiers in Public Health 8.
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Milad Ashrafizadeh, Ali Zarrabi, Sima Orouei, Vahideh Zarrin, Ebrahim Rahmani Moghadam, Amirhossein Zabolian, Shima Mohammadi, Kiavash Hushmandi, Yashar Gharehaghajlou, Pooyan Makvandi, Masoud Najafi & Reza Mohammadinejad. (2020) STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects. Biology 9:6, pages 126.
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Muhammad T. Islam, Eunus S. Ali, Shaikh J. Uddin, Ishaq N. Khan, Manik C. Shill, João M. de Castro e Sousa, Marcus V.O. Barros de Alencar, Ana A.C. Melo-Cavalcante & Mohammad S. Mubarak. (2020) Anti-Cancer Effects of Asiatic Acid, a Triterpene from Centilla asiatica L: A Review. Anti-Cancer Agents in Medicinal Chemistry 20:5, pages 536-547.
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Yen-Tze Liu, Yi-Ching Chuang, Yu-Sheng Lo, Chia-Chieh Lin, Yi-Ting Hsi, Ming-Ju Hsieh & Mu-Kuan Chen. (2020) Asiatic Acid, Extracted from Centella asiatica and Induces Apoptosis Pathway through the Phosphorylation p38 Mitogen-Activated Protein Kinase in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells. Biomolecules 10:2, pages 184.
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Hongming Song, Qifeng Luo, Xiaochong Deng, Changle Ji, Dengfeng Li, Amik Munankarmy, Wei Jian, Junyong Zhao & Lin Fang. (2019) VGLL4 interacts with STAT3 to function as a tumor suppressor in triple-negative breast cancer. Experimental & Molecular Medicine 51:11, pages 1-13.
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Yue Jing, Yue Jin, Yujia Wang, Sheng Chen, Xiaoxin Zhang, Yuxian Song, Zhiyong Wang, Yumei Pu, Yanhong Ni & Qingang Hu. (2019) SPARC promotes the proliferation and metastasis of oral squamous cell carcinoma by PI3K/AKT/PDGFB/PDGFRβ axis. Journal of Cellular Physiology 234:9, pages 15581-15593.
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Mohamed Fizur Nagoor Meeran, Sameer N. Goyal, Kapil Suchal, Charu Sharma, Chandragouda R. Patil & Shreesh K. Ojha. (2018) Pharmacological Properties, Molecular Mechanisms, and Pharmaceutical Development of Asiatic Acid: A Pentacyclic Triterpenoid of Therapeutic Promise. Frontiers in Pharmacology 9.
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Xuan Zhang, Silin Zhang, Qitong Sun, Wenjun Jiao, Yan Yan & Xuewu Zhang. (2018) Compound K Induces Endoplasmic Reticulum Stress and Apoptosis in Human Liver Cancer Cells by Regulating STAT3. Molecules 23:6, pages 1482.
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Jorge A.R. Salvador, Ana S. Leal, Ana S. Valdeira, Bruno M.F. Gonçalves, Daniela P.S. Alho, Sandra A.C. Figueiredo, Samuel M. Silvestre & Vanessa I.S. Mendes. (2017) Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment. European Journal of Medicinal Chemistry 142, pages 95-130.
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