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Original Research

Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells

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Pages 7481-7492 | Published online: 12 Dec 2016

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Yue Gao, Shiyu Chen, Jiayi Sun, Siyu Su, Dong Yang, Li Xiang & Xianli Meng. (2020) Traditional Chinese medicine may be further explored as candidate drugs for pancreatic cancer: A review. Phytotherapy Research 35:2, pages 603-628.
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Muthusamy Muthusamy, Jong Hee Kim, Suk Hee Kim, Joo Yeol Kim, Jeong Wook Heo, HanGyeol Lee, Kwang-Sik Lee, Woo Duck Seo, Soyoung Park, Jin A Kim & Soo In Lee. (2020) Changes in Beneficial C-glycosylflavones and Policosanol Content in Wheat and Barley Sprouts Subjected to Differential LED Light Conditions. Plants 9:11, pages 1502.
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Wan‑Ting Xu, Gui‑Nan Shen, Tian‑Zhu Li, Yu Zhang, Tong Zhang, Hui Xue, Wen‑Bo Zuo, Yan‑Nan Li, Dong‑Jie Zhang & Cheng‑Hao Jin. (2020) Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways. International Journal of Oncology 57:2, pages 550-561.
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Yangmei Zhang, Xichang Zhou, Long Cheng, Xiang Wang, Qinglin Zhang, Youwei Zhang & Sanyuan Sun. (2020) PRKAA1 Promotes Proliferation and Inhibits Apoptosis of Gastric Cancer Cells Through Activating JNK1 and Akt Pathways. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 28:3, pages 213-223.
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Hsu-Kai Huang, Shin-Yi Lee, Shu-Fen Huang, Yu-San Lin, Shih-Chi Chao, Shu-Fu Huang, Shih-Chun Lee, Tzu-Hurng Cheng, Shih-Hurng Loh & Yi-Ting Tsai. (2020) Isoorientin Decreases Cell Migration via Decreasing Functional Activity and Molecular Expression of Proton-Linked Monocarboxylate Transporters in Human Lung Cancer Cells. The American Journal of Chinese Medicine 48:01, pages 201-222.
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Pierre B. Kasangana, Hoda M. Eid, Abir Nachar, Tatjana Stevanovic & Pierre S. Haddad. (2019) Further isolation and identification of anti-diabetic principles from root bark of Myrianthus arboreus P. Beauv.: The ethyl acetate fraction contains bioactive phenolic compounds that improve liver cell glucose homeostasis. Journal of Ethnopharmacology 245, pages 112167.
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V.C. Graça, Ricardo C. Calhelha, Fernando M. Nunes, Jérôme Berthet, Isabel C.F.R. Ferreira & P.F. Santos. (2019) Isolation of secondary metabolites from Geranium molle L. with anticancer potential. Industrial Crops and Products 142, pages 111859.
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Guoxin Zhang, Ning Liu, Chunhao Zhu, Lin Ma, Jiamei Yang, Juan Du, Wenjin Zhang, Tao Sun, Jianguo Niu & Jianqiang Yu. (2019) Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice. International Immunopharmacology 75, pages 105753.
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Xiaoye Fan, Hongming Lv, Lidong Wang, Xuming Deng & Xinxin Ci. (2018) Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3β. Frontiers in Pharmacology 9.
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Dehong Huang, Lei jin, Zhengkang Li, Ji Wu, Ni Zhang, Dianrong Zhou, Xiaorong Ni & Tieying Hou. (2018) Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair. Biomedicine & Pharmacotherapy 101, pages 719-728.
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