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Original Research

Salinomycin repressed the epithelial–mesenchymal transition of epithelial ovarian cancer cells via downregulating Wnt/β-catenin pathway

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Pages 1317-1325 | Published online: 28 Feb 2017

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Fang Liu, Rong-Bin Lv, Yan Liu, Qian Hao, Shu-Jie Liu, Yuan-Yuan Zheng, Cui Li, Cheng Zhu & Min Wang. (2020) Salinomycin and Sulforaphane Exerted Synergistic Antiproliferative and Proapoptotic Effects on Colorectal Cancer Cells by Inhibiting the PI3K/Akt Signaling Pathway in vitro and in vivo. OncoTargets and Therapy 13, pages 4957-4969.
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Yunxia Zhang, Jing Wang, Di Wu, Miao Li, Fenshu Zhao, Mulan Ren, Yunlong Cai & Jun Dou. (2018) IL-21-secreting hUCMSCs combined with miR-200c inhibit tumor growth and metastasis via repression of Wnt/β-catenin signaling and epithelial–mesenchymal transition in epithelial ovarian cancer. OncoTargets and Therapy 11, pages 2037-2050.
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Xiangqi Meng, Jinquan Cai, Jichao Liu, Bo Han, Fei Gao, Weida Gao, Yao Zhang, Jinwei Zhang, Zhefeng Zhao & Chuanlu Jiang. (2017) Curcumin increases efficiency of γ-irradiation in gliomas by inhibiting Hedgehog signaling pathway. Cell Cycle 16:12, pages 1181-1192.
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Oana Gabriela Trifanescu, Raluca Alexandra Trifanescu, Radu Iulian Mitrica, Diana Maria Bran, Georgia Luiza Serbanescu, Laurentiu Valcauan, Serban Andrei Marinescu, Laurentia Nicoleta Gales, Bogdan Cosmin Tanase & Rodica Maricela Anghel. (2023) The Female Reproductive Tract Microbiome and Cancerogenesis: A Review Story of Bacteria, Hormones, and Disease. Diagnostics 13:5, pages 877.
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Jian Chen, Jia Liu, Shimin Chen, Ruijun Lai, Chuanchuan Zheng, Jialiang Lu, Xinshao Jiang, Feng He, Chengliang Yang, Kai Li, Kegong Xie, Yujin Tang & Liqiang Wang. (2022) Salinomycin alleviates osteoarthritis progression via inhibiting Wnt/β-catenin signaling. International Immunopharmacology 112, pages 109225.
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ABDELKRIM ALILECHE. (2022) The IC-50-time evolution is a new model to improve drug responses consistency of large scale studies. F1000Research 11, pages 284.
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Adrienn Sipos, Gyula Ujlaki, Edit Mikó, Eszter Maka, Judit Szabó, Karen Uray, Zoárd Krasznai & Péter Bai. (2021) The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling. Molecular Medicine 27:1.
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Donald Rozario, Sammer Zeglam & Wolfram Siede. (2021) A Yeast Mutant Screen Identifies TORC and Lys63 Polyubiquitination Pathway Genes among Determinants of Sensitivity to the Cancer Stem Cell-Specific Drug Salinomycin. Journal of Analytical Oncology 9, pages 33-45.
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Julia López de Andrés, Carmen Griñán-Lisón, Gema Jiménez & Juan Antonio Marchal. (2020) Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment. Journal of Hematology & Oncology 13:1.
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Till Kaltofen, Valentina Preinfalk, Stephanie Schwertler, Patricia Fraungruber, Helene Heidegger, Theresa Vilsmaier, Aurelia Vattai, Bastian Czogalla, Doris Mayr, Sven Mahner, Udo Jeschke & Fabian Trillsch. (2020) Potential of platinum-resensitization by Wnt signaling modulators as treatment approach for epithelial ovarian cancer. Journal of Cancer Research and Clinical Oncology 146:10, pages 2559-2574.
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Mahdi Zarei, Marie S. Jazi, Mahboubeh Tajaldini, Ayyoob Khosravi & Jahanbakhsh Asadi. (2020) Selective Inhibition of Esophageal Cancer Stem-like Cells with Salinomycin. Anti-Cancer Agents in Medicinal Chemistry 20:7, pages 783-789.
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Marcin Michalak, Michał Stefan Lach, Michał Antoszczak, Adam Huczyński & Wiktoria Maria Suchorska. (2020) Overcoming Resistance to Platinum-Based Drugs in Ovarian Cancer by Salinomycin and Its Derivatives—An In Vitro Study. Molecules 25:3, pages 537.
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Katerina Strouhalova, Magdalena Přechová, Aneta Gandalovičová, Jan Brábek, Martin Gregor & Daniel Rosel. (2020) Vimentin Intermediate Filaments as Potential Target for Cancer Treatment. Cancers 12:1, pages 184.
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Ya‐Long Feng, Dan‐Qian Chen, Nosratola D. Vaziri, Yan Guo & Ying‐Yong Zhao. (2019) Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis. Medicinal Research Reviews 40:1, pages 54-78.
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Teeuwssen & Fodde. (2019) Wnt Signaling in Ovarian Cancer Stemness, EMT, and Therapy Resistance. Journal of Clinical Medicine 8:10, pages 1658.
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Zonglei Mao, Yong Wu, Jin Zhou & Chungen Xing. (2019) Salinomycin reduces epithelial–mesenchymal transition-mediated multidrug resistance by modifying long noncoding RNA HOTTIP expression in gastric cancer cells. Anti-Cancer Drugs 30:9, pages 892-899.
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Michał Antoszczak & Adam Huczyński. (2019) Salinomycin and its derivatives – A new class of multiple-targeted “magic bullets”. European Journal of Medicinal Chemistry 176, pages 208-227.
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Carolina Sousa, Luís F. Gouveia, Bruna Kreutzer, Beatriz Silva-Lima, Retsepile E. Maphasa, Admire Dube & Mafalda Videira. (2019) Polymeric Micellar Formulation Enhances Antimicrobial and Anticancer Properties of Salinomycin. Pharmaceutical Research 36:6.
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Li-Ya Zhang, Yuan Chen, Jue Jia, Xi Zhu, Yan He & Li-Ming Wu. (2019) MiR-27a promotes EMT in ovarian cancer through active Wnt/𝜷-catenin signalling by targeting FOXO1. Cancer Biomarkers 24:1, pages 31-42.
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Michał Antoszczak. (2019) A medicinal chemistry perspective on salinomycin as a potent anticancer and anti-CSCs agent. European Journal of Medicinal Chemistry 164, pages 366-377.
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Björn L.D.M. Brücher & Ijaz S. Jamall. (2019) Undervalued ubiquitous proteins. 4open 2, pages 7.
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Björn L.D.M. Brücher & Ijaz S. Jamall. (2019) Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress. 4open 2, pages 14.
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Jingcao Li, Lan Sun, Yan Liu, Hongjuan Yao, Shuang Jiang, YunzhuPu, Yajuan Li & Yingge Zhang. (2019) To reduce premature drug release while ensuring burst intracellular drug release of solid lipid nanoparticle-based drug delivery system with clathrin modification. Nanomedicine: Nanotechnology, Biology and Medicine 15:1, pages 108-118.
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Vivek Kaushik, Juan Yakisich, Anil Kumar, Neelam Azad & Anand Iyer. (2018) Ionophores: Potential Use as Anticancer Drugs and Chemosensitizers. Cancers 10:10, pages 360.
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Antoine Versini, Lou Saier, Fabien Sindikubwabo, Sebastian Müller, Tatiana Cañeque & Raphaël Rodriguez. (2018) Chemical biology of salinomycin. Tetrahedron 74:39, pages 5585-5614.
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Wenjie Zhang, Feng Yu, Yu Wang, Yu Zhang, Lingxin Meng & Yuhua Chi. (2018) Rab23 promotes the cisplatin resistance of ovarian cancer via the Shh-Gli-ABCG2 signaling pathway. Oncology Letters.
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Li Hou, Xiaofei Hou, Lijing Wang, Zenghui Li, Beibei Xin, Jing Chen, Xiaofei Gao & Haixia Mu. (2017) PD98059 impairs the cisplatin-resistance of ovarian cancer cells by suppressing ERK pathway and epithelial mesenchymal transition process. Cancer Biomarkers 21:1, pages 187-194.
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